Naphthol AS-E - Moligand™, 10 mM in DMSO , CAS No.92-78-4

CAS: 92-78-4 Cat. No.: N1493756 Molecular Weight: 297.74 Beilstein Registry Number: 12(4)1223 EC Number: 202-189-7

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Naphthol AS-E is a potent and cell-permeable inhibitor of KIX-KID interaction . Naphthol AS-E directly binds to the KIX domain of CBP ( K d :8.6 μM), blocks the interaction between the KIX domain and the KID domain of CREB with IC 50 of 2.26 μM. Naphthol AS-E can be used for cancer research.

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: C1=CC=C2C=C(C(=CC2=C1)C(=O)NC3=CC=C(C=C3)Cl)O
• Molecular Weight: 297.74
• Beilstein: 12(4)1223
• Reaxy-Rn: 2745886
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2745886&ln=

Chemical and Physical Properties

• Melt Point(°C): 264°C(lit.)

References

1. Min Jiang, Yufei Yan, Kai Yang, Zhuochao Liu, Jin Qi, Hanbing Zhou, Niandong Qian, Qi Zhou, Tianqi Wang, Xing Xu, Xiangshu Xiao, Lianfu Deng.  (2018)  Small molecule nAS-E targeting cAMP response element binding protein (CREB) and CREB-binding protein interaction inhibits breast cancer bone metastasis.  JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,  23  (2): (1224-1234).  [PMID:30461194] [10.1111/jcmm.14024]