Naproxen etemesil - 10mM in DMSO , Cyclooxygenase inhibitor, CAS No.385800-16-8, Cyclooxygenase inhibitor

CAS: 385800-16-8 Cat. No.: N655468 Summenformel: C₁₇H₂₀O₅S Molekulargewicht: 336.40 PubChem CID: 25170420

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Naproxen etemesil is a lipophilic, non-acidic, inactive proagent of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC 50 s of 8.72 and 5.15 μM, respectively in cell assay.

In Vitro

Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC 50 s of 2.2 μg/mL and 1.3 μg/mL, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Naproxen exerts an anti-inflammatory and antifibrotic effect in mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation. Naproxen is shown to inhibit the time-courses of pain, fever and PGE2 with similar potencies (IC 50 =27, 40, 13 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 8.72 μM (COX-1), 5.15 μM (COX-2)

Specifications

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

Naproxen etemesil is a lipophilic, non-acidic, inactive proagent of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC 50 s of 8.72 and 5.15 μM, respectively in cell assay.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Mechanismus der Wirkung

Cyclooxygenase inhibitor

Produkteigenschaften

• ALogP: 2.5

Namen und Kennungen

• Isomere SMILES: C[C@@H](C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)OCCS(=O)(=O)C
• Alternative CAS-Nummer: 385800-16-8
• PubChem CID: 25170420
• Molekulargewicht: 336.40

Häufig gestellte Fragen

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 385800-16-8, the molecular formula is C17H20O5S, and the molecular weight is 336.40 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.