≥97% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Room temperature,Argon charged Ships Normal Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Product description
NDSB 221 is a nondetergent sulfobetaine that has been found to improve unfolding reversibility.
Product Application
NDSB 221 has been used in a study to identify a novel ligand binding site in phosphoserine phosphatase from Thermococcus onnurineus. It has also been used in a study to investigate its effects on acidic fibroblast growth factor (aFGF).
Non-detergent sulfobetaine is a compound used for non-denaturing protien purification. Increases the extraction yield of membrane, nuclear and cytoskeletal associated proteins. Zwitterionic over a wide pH range, easily removed by dialysis and no significant absorption in the near UV range. Specific applications include microsomal protein extraction, nuclear protein recovery, precipitation reduction in IEF, and membrane-bound protease purification. The typical usage concentration is 0.5 - 2.0 M.
| Pubchem Sid | 488196547 |
|---|---|
| Canonical Smiles | C[N+]1(CCCCC1)CCCS(=O)(=O)[O-] |
| IUPAC Name | 3-(1-methylpiperidin-1-ium-1-yl)propane-1-sulfonate |
| InChIKey | DQNQWAVIDNVATL-UHFFFAOYSA-N |
| INCHI | 1S/C9H19NO3S/c1-10(6-3-2-4-7-10)8-5-9-14(11,12)13/h2-9H2,1H3 |
| Isomeric SMILES | C[N+]1(CCCCC1)CCCS(=O)(=O)[O-] |
| Molecular Weight | 221.32 |
| Reaxy-Rn | 30123612 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=30123612&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Piperidines |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Piperidines |
| Alternative Parents | Tetraalkylammonium salts Sulfonyls Organosulfonic acids Alkanesulfonic acids Azacyclic compounds Organopnictogen compounds Organic salts Organic oxides Hydrocarbon derivatives Amines |
| Molecular Framework | Aliphatic heteromonocyclic compounds |
| Substituents | Piperidine - Quaternary ammonium salt - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Organosulfonic acid - Sulfonyl - Alkanesulfonic acid - Tetraalkylammonium salt - Azacycle - Organic nitrogen compound - Organosulfur compound - Organonitrogen compound - Organic salt - Hydrocarbon derivative - Amine - Organic oxide - Organopnictogen compound - Organic oxygen compound - Aliphatic heteromonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as piperidines. These are compounds containing a piperidine ring, which is a saturated aliphatic six-member ring with one nitrogen atom and five carbon atoms. |
| External Descriptors | ammonium betaine |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 I2320758 | Certificate of Analysis | Jan 20, 2026 | N276111 |
| I2320759 | Certificate of Analysis | Jan 20, 2026 | N276111 |
| I2320760 | Certificate of Analysis | Jan 20, 2026 | N276111 |
| K2510621 | Certificate of Analysis | Nov 12, 2025 | N276111 |
| I2320761 | Certificate of Analysis | Jul 09, 2024 | N276111 |
| Solubility | Soluble in water to 100 mM |
|---|---|
| Sensitivity | Moisture sensitive |
| Molecular Weight | 221.320 g/mol |
| XLogP3 | 0.300 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 3 |
| Exact Mass | 221.109 Da |
| Monoisotopic Mass | 221.109 Da |
| Topological Polar Surface Area | 65.600 Ų |
| Heavy Atom Count | 14 |
| Formal Charge | 0 |
| Complexity | 249.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
