neolymphostin A - Moligand™ , Inhibitor of LCK proto-oncogene; Src family tyrosine kinase;Inhibitor of mechanistic target of rapamycin kinase;Inhibitor of phosphatidylinositol-4;5-bisphosphate 3-kinase catalytic subunit alpha;Inhibitor of phosphatidylinos, Inhibitor of LCK proto-oncogene; Src family tyrosine kinase;Inhibitor of mechanistic target of rapamycin kinase;Inhibitor of phosphatidylinositol-4;5-bisphosphate 3-kinase catalytic subunit alpha;Inhibitor of phosphatidylinositol-4;5-bisphosphate 3-kinase
neolymphostin A - Moligand™ , Inhibitor of LCK proto-oncogene; Src family tyrosine kinase;Inhibitor of mechanistic target of rapamycin kinase;Inhibitor of phosphatidylinositol-4;5-bisphosphate 3-kinase catalytic subunit alpha;Inhibitor of phosphatidylinos, Inhibitor of LCK proto-oncogene; Src family tyrosine kinase;Inhibitor of mechanistic target of rapamycin kinase;Inhibitor of phosphatidylinositol-4;5-bisphosphate 3-kinase catalytic subunit alpha;Inhibitor of phosphatidylinositol-4;5-bisphosphate 3-kinase
GRADE & PURITYMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
Moligand™ Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Room temperature Ships Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications
Synonyme
compound 4
Spezifikationen & Reinheit
Moligand™
Storage
Room temperature
Note
Moligand™
Aktionsart
INHIBITOR
Mechanismus der Wirkung
Inhibitor of LCK proto-oncogene; Src family tyrosine kinase;Inhibitor of mechanistic target of rapamycin kinase;Inhibitor of phosphatidylinositol-4;5-bisphosphate 3-kinase catalytic subunit alpha;Inhibitor of phosphatidylinositol-4;5-bisphosphate 3-kinase
This compound belongs to the class of organic compounds known as aminoquinolines and derivatives. These are organic compounds containing an amino group attached to a quinoline ring system.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Zertifikate (CoA, COO, BSE/TSE und Analyse-Diagramm)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Lösungsrechner
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Application Protocols
There are no manufacturer-validated application protocols listed for this item. The following outline provides general, non-binding guidance for handling small molecules in screening workflows:
Stock preparation: Dissolve compound in anhydrous DMSO to a convenient concentration (e.g., 10 mM). Vortex and, if needed, sonicate briefly. Filter through a low-binding 0.2 µm membrane if particulate persists.
Working solutions: Dilute the stock into assay buffer or culture media to the desired final concentration, maintaining constant vehicle percentage across controls and treatments.
Plate handling: Use low-binding polypropylene plates or tubes for hydrophobic compounds; pre-rinse tips with solution to improve accuracy at low volumes.
Stability checks: Verify short-term stability in assay matrix by LC–MS or UV over representative time windows.
Item-specific recommendations (dilutions, positive controls, detection settings): Not specified for this item; refer to CoA/Spec Sheet and optimize within your laboratory.
Biological Roles
No item-specific biological targets or mechanisms are provided in this listing. The following notes reflect general, literature-oriented context for complex small molecules used in discovery research and should not be taken as claims for this specific batch.
Literature context: Neolymphostin-class compounds are described in the scientific literature as structurally complex, secondary-metabolite–like small molecules. Reported studies often explore their interactions with cellular signaling pathways using biochemical and cellular assays. Users should consult primary publications for details relevant to their application and verify against the supplied CoA/SDS.
Research utility (general): In chemical biology, such compounds are frequently employed as reference entities for assay validation, pathway perturbation studies, and structure–activity relationship (SAR) exploration.
Assay considerations: Ensure the working concentration is guided by your internal dose–response curves and that vehicle controls are included to account for solvent effects.
Important: This product is provided strictly for research use only. No clinical, diagnostic, or therapeutic use is intended or permitted.
Buffer Applications
This product is not a buffer component and is not typically used to formulate buffering systems. If incorporating into biochemical assays:
Prepare a concentrated stock in DMSO or another compatible organic solvent, then dilute into the desired buffer (e.g., HEPES, PBS, Tris) while maintaining a low final organic percentage (commonly ≤0.1–1%).
Verify solubility and avoid precipitation upon dilution; gentle vortexing and incremental titration of the stock into buffer can help.
Include matched vehicle controls to account for any solvent contributions in the assay readout.
No item-specific buffer pKa ranges, ionic strengths, or recipes are applicable.
Green Alternatives
As a screening/reference compound rather than a process solvent or bulk reagent, green-chemistry considerations focus on solvent selection and solution handling rather than replacement of the molecule itself.
Greener handling strategies (general):
Prefer DMSO or ethanol for stock solutions when assay-compatible, minimizing use of higher-toxicity dipolar aprotics (e.g., DMF, NMP). Use the lowest feasible co-solvent percentage in aqueous buffers.
Employ microscale assay formats and high-concentration stocks to reduce solvent volume and waste.
Utilize closed-vial dissolution with brief sonication to limit operator exposure and solvent loss.
Illustrative comparison (general guidance):
DMSO vs DMF/NMP: DMSO typically offers a better EHS profile and assay compatibility; DMF/NMP may be reserved for solubility-challenged cases.
Ethanol vs methanol: Ethanol is generally preferred from a toxicity standpoint, provided the compound’s solubility allows.
Waste minimization:
Collect dilute assay waste streams separately to facilitate appropriate disposal; consider miniaturized screening (96- to 1536-well) to reduce solvent throughput.
Pharmaceutical Uses
No pharmacopeial status, excipient role, or formulation use is provided for this item. This product is sold exclusively for research use.
General considerations for research formulation (non-clinical, non-GMP):
For in vitro studies: DMSO or ethanol stocks diluted into assay media; maintain solvent below assay tolerance thresholds.
For exploratory in vivo research (if undertaken by qualified laboratories under appropriate approvals): Solubilization strategies may involve co-solvents, cyclodextrins, or lipid-based vehicles. Any such use must be independently validated and is outside the scope of this catalog listing.
Important: Not for human or veterinary use; not for diagnostic or therapeutic applications.
Physical Properties
Item-specific physical constants are not provided in this listing. For definitive specifications, consult the lot-specific CoA/Spec Sheet.
Appearance: Not specified for this item; refer to CoA/Spec Sheet.
Melting point: Not specified for this item; refer to CoA/Spec Sheet.
Boiling point: Not applicable/rarely specified for complex, non-volatile small molecules; refer to CoA/Spec Sheet if available.
Density: Not specified for this item; refer to CoA/Spec Sheet.
Solubility: Not specified for this item; refer to CoA/Spec Sheet. General guidance (literature/practice): complex, polyfunctional small molecules are often prepared as DMSO stock solutions (e.g., 1–20 mM) and subsequently diluted into aqueous buffers containing co-solvent.
LogP/logD: Not specified for this item; refer to CoA/Spec Sheet.
pKa(s): Not specified for this item; refer to CoA/Spec Sheet.
Refractive index: Not applicable to solids; Not specified for this item; refer to CoA/Spec Sheet.
General handling observations (experience-based, non-specification):
Many library compounds of this class exhibit limited aqueous solubility; dissolution can be improved by warming to ambient temperature, brief sonication, or using high-purity DMSO, ethanol, or DMF as primary solvents before aqueous dilution.
Hygroscopicity or photolability, if any, should be confirmed from the SDS/CoA; protect from light until verified.
Quality and Grades
Grade/Purity: Moligand™
What Moligand™ implies (general description):
Intended for discovery research, screening, and chemical biology where reliable identity is paramount and ultra-trace analytical specifications (e.g., UV cutoff, metal ppm) are not the primary requirement.
Typically accompanied by batch-level identity confirmation (e.g., NMR/HRMS/LC-MS) suitable for screening libraries; refer to the CoA for the exact analytical package supplied with this lot.
What is and is not specified here:
Purity percentage, residual solvent profile, water content, and stabilizers: Not specified for this item; refer to CoA/Spec Sheet.
Chromatographic suitability (HPLC/LC-MS baselines), counterion content, and salt form: Not specified for this item; refer to CoA/Spec Sheet.
Practical considerations for users:
For SAR, biochemical screens, or phenotypic assays, verify identity and purity against the provided CoA prior to use. If quantitative studies are planned, consider in-house orthogonal confirmation (e.g., quantitative NMR) and solubility checks in your assay matrix.
If you require enhanced analytical attributes (e.g., trace metal limits, elemental analysis), contact us for current lot documentation or custom material.
Reaction and Applications
This product is supplied primarily as a reference/screening small molecule rather than as a synthetic reagent. It is not typically employed as a coupling component or stoichiometric reagent in routine organic synthesis.
Research applications (general, non-targeted):
Use as a well-characterized small molecule in discovery screening panels (e.g., chemical biology or phenotypic assays), concentration–response studies, and as a reference control where appropriate.
Analytical benchmarking: can support method development in LC–MS bioanalytical workflows (retention time, ionization behavior) once an authentic standard is on hand.
If derivatization is contemplated (general guidance):
Complex natural product–like scaffolds often contain multiple reactive handles (e.g., phenolic, enolic, or heteroatom functionalities). Any late-stage functionalization should be guided by structure-confirmed material and literature precedents for the specific scaffold.
Protecting-group strategies and chemoselective conditions will be crucial; confirm stability in the presence of bases, acids, and oxidants before multi-step sequences.
Notes:
No manufacturer-supplied reaction examples are provided for this item. For any synthetic use, verify structure and reactivity from primary literature or by pilot reactions with small quantities.
Reaction Conditions
There are no manufacturer-supplied reaction conditions for this product. The compound is not primarily intended as a reagent. If users elect to derivatize or formulate it, consider the following general practices for complex small molecules:
Solvents: Dry DMSO, DMF, or acetonitrile for mild functionalizations; alcohols for solvolysis or acyl transfers when appropriate.
Temperatures: Begin at ambient temperature; escalate cautiously (≤40–60 °C) after confirming stability by TLC/LC–MS.
Atmosphere: Use inert gas (N2/Ar) if moisture/oxygen sensitivity is suspected; confirm by small-scale trials.
Catalysts/bases: Select mild, chemoselective systems (e.g., carbonate bases, Pd-catalyzed cross-couplings under low temperature) only when supported by the known functional groups of the structure as confirmed from the CoA/literature.
Workup: Quench carefully and avoid extreme pH; extract with appropriate solvents and analyze promptly to assess integrity.
Expected yields/times: Not applicable; any figures would be system-specific and must be established empirically for the confirmed scaffold.
Safety and Handling
GHS classification and hazard statements are not provided in this listing; always consult the item-specific SDS for authoritative safety information.
Signal word: Not specified for this item; refer to SDS.
Hazard statements (H-codes): Not specified for this item; refer to SDS.
Pictograms: Not specified for this item; refer to SDS.
General laboratory precautions (best practice):
Use in a chemical fume hood to avoid inhalation of dusts/aerosols.
Wear appropriate PPE: lab coat, safety glasses, and impervious gloves (e.g., nitrile). Consider double-gloving for extended handling of DMSO solutions.
Avoid skin/eye contact and inhalation; prevent ingestion and environmental release.
Incompatibilities and stability (general guidance):
Avoid strong oxidizers and strong acids/bases unless stability is known from the SDS/CoA or primary literature.
Protect from excessive heat and direct light until stability is confirmed.
First-aid overview (refer to SDS for details):
Inhalation: Move to fresh air; seek medical attention if symptoms occur.
Skin/eye contact: Rinse cautiously with water for several minutes; remove contaminated clothing; seek medical attention if irritation persists.
Ingestion: Rinse mouth; do not induce vomiting; seek medical advice.
Waste disposal: Collect residues and contaminated materials as halogen-free organic waste unless otherwise stated in SDS; dispose according to institutional and local regulations.
Solvent Selection
Item-specific solubility data are not provided; select solvents based on general behavior of complex, polyfunctional small molecules used in screening.
Primary stock solvents (common practice):
DMSO (anhydrous, ≥99.9%): preferred for preparing concentrated stocks (e.g., 1–20 mM). Offers broad solvency and assay compatibility at low final percentages.
DMF or NMP: alternatives when DMSO solubility is inadequate; assess assay tolerance.
Ethanol or methanol: suitable for less polar analogs; volatility facilitates rapid dilution but may limit maximum stock concentration.
Aqueous handling:
Pre-dissolve in an aprotic solvent (e.g., DMSO), then dilute into buffer with vigorous mixing to avoid precipitation.
Include co-solvent (0.1–1% DMSO or EtOH) in assay buffers if needed; verify biological assay tolerance.
Polarity and miscibility (general):
Expect low water solubility for densely functionalized, neutral/weakly ionizable scaffolds; ionic or salt forms (if applicable) can alter this—confirm with CoA.
Small comparison (general guidance):
DMSO vs DMF: DMSO has better biocompatibility in many assays but may interact with certain enzymes; DMF can improve solubility for highly lipophilic compounds but is less assay-friendly.
EtOH/MeOH: convenient for fast evaporation, but limit final concentration to avoid assay interference.
Storage and Reconstitution
Storage conditions (from Product Data):
Store at room temperature.
Additional best practices (general guidance; not item-specific specifications):
Keep container tightly closed in a dry, well-ventilated place; protect from direct light until stability is confirmed.
For long-term retention of integrity, many users store solid small molecules desiccated and, if feasible, under inert atmosphere. If stability is uncertain, consider 2–8 °C storage as a precaution while avoiding condensation.
Reconstitution guidance (general):
Prepare concentrated stock solutions in anhydrous DMSO (common range 1–20 mM). If using alternative solvents (DMF, ethanol), verify compatibility with downstream assays.
After reconstitution, aliquot to minimize freeze–thaw and headspace exposure. For DMSO stocks, storage at −20 °C or −80 °C in sealed, light-protective vials is commonly practiced; verify stability empirically.
Thaw aliquots at ambient temperature and mix thoroughly before use; avoid repeated freeze–thaw cycles.
Shipped in: Not specified for this item; refer to CoA/Spec Sheet.
Appearance: Not specified for this item; refer to CoA/Spec Sheet.
Structure and Identity
Brief description: Neolymphostin A is listed in our small-molecule/compound library as a complex, research-grade small molecule (Moligand™ grade). Item-specific identifiers are limited in this listing; consult the CoA/Spec Sheet for definitive structural details.
Product name (catalog): neolymphostin A (SKU: N612219)
CAS: Not specified for this item; refer to CoA/Spec Sheet.
InChIKey: Not specified for this item; refer to CoA/Spec Sheet.
SMILES: Not specified for this item; refer to CoA/Spec Sheet.
Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
Structural features (general, literature context):
Neolymphostin A is reported in the literature as a structurally complex natural product–like small molecule. Exact ring systems, functional groups, and stereochemical configuration should be verified against the supplied batch documentation (CoA/SDS).
2D description (general): A polyfunctional scaffold bearing multiple heteroatoms and conjugated elements typical of densely functionalized natural-product frameworks. Do not assume a specific regiochemistry/stereochemistry without referring to the lot-specific CoA.
Identity and traceability:
Grade: Moligand™ (screening-grade small molecule for discovery research)
Category path: 全部 / 可售 / 小分子和化合物库
Research use: For research use only
Synthetic Utility
This molecule is offered primarily as a screening/reference compound rather than as a building block. Consequently, direct synthetic utility is limited compared to commodity reagents.
If the scaffold presents modifiable positions (e.g., phenolic OH, halogen, alkene, or amide/ester moieties as found in many complex small molecules), late-stage diversification could be explored via mild cross-couplings, O-alkylations/acylations, or conjugations for probe development. Such modifications must be guided by a confirmed structure and supported by pilot reactions.
Stability mapping is recommended before modifications: test tolerance to bases (e.g., carbonate, tertiary amines), acids (e.g., TFA, HCl in dioxane), and oxidants/reductants under dilute conditions.
Caveat:
Without an item-specific, verified structure in hand, no reaction roadmap should be assumed. Users should consult the CoA and primary literature for neolymphostin A prior to any synthetic manipulation.
Target Specificity
No target, binding partner, or selectivity profile is provided for this catalog item. Target specificity data are not specified; refer to the primary literature on neolymphostin-class compounds and your own assay results for application-specific insights.
Tested targets/epitopes: Not specified for this item; refer to CoA/Spec Sheet.
Species reactivity/assay scope: Not specified for this item; refer to CoA/Spec Sheet.
Note: Any biological target claims must be validated independently within the user’s assay system.
Häufig gestellte Fragen
What is Moligand??
Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.
How should this product be stored?
Store at room temperature.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is N612219. InChIKey OKZVXALNOKYCRL-SNAWJCMRSA-N.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
Need help choosing the grade?
Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.
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