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neurturin, CAS No.rp174632

CAS: rp174632 Cat. No.: rp174632
COA
neurturin, CAS No.rp174632
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GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
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Size
Deutschland (EU)
USA*
Price
Qty
500μg
rp174632-500μg
Auf Bestellung · 8–12 Wochen
2.082,49€
1mg
rp174632-1mg
Auf Bestellung · 8–12 Wochen
3.470,87€
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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Specifications Lagerung und Versand Documentation Advanced Data Zugehörige Ziele (menschlich) Zertifikate (CoA, COO, BSE/TSE und Analyse-Diagramm) Genetische Informationen Lösungsrechner Bewertungen Häufig gestellte Fragen Application Protocols Biological Roles Buffer Applications Green Alternatives Pharmaceutical Uses Physical Properties Quality and Grades Reaction and Applications Reaction Conditions Safety and Handling Solvent Selection Storage and Reconstitution Structure and Identity Synthetic Utility Target Specificity
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Why this grade

Moligand™ Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Room temperature Ships Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Product Name
neurturin, CAS No.rp174632
Synonyme
NRTN
Note
Moligand™
Spezifikationen & Reinheit
Moligand™
CAS
rp174632
Molekültyp
Peptide
Product Line
Biologische Produkte
Lagerung und Versand
Storage
Room temperature

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Zugehörige Ziele (menschlich)
NRTN Tbio Neurturin (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Zertifikate (CoA, COO, BSE/TSE und Analyse-Diagramm)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Genetische Informationen
Alternate NamesNRTN
Referenz
  • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
  • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
  • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
  • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
  • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
  • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
  • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
  • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
  • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
  • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more
Lösungsrechner
Bewertungen

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Application Protocols

  • Item-specific validated applications and recommended conditions: Not specified for this item; refer to CoA/Spec Sheet.

  • General example workflows (illustrative; not item-specific)

    • RET phosphorylation assay (cells):
      1. Culture a GFRα2/RET-positive cell line to ~80% confluence.
      2. Serum-starve 2–4 h, then treat with a concentration series of neurturin (e.g., sub-nM to 50 nM) for 5–30 min.
      3. Lyse and quantify phospho-RET/ERK by immunoassay; normalize to total protein.
    • Neurite outgrowth assay (primary or neuronal cell model):
      1. Plate cells on poly-D-lysine/laminin-coated plates.
      2. Add neurturin over a titration range alongside vehicle and related GFL controls.
      3. Image after 24–72 h; quantify neurite length/branching.
    • Ligand–receptor binding (biochemical):
      1. Immobilize receptor ectodomain or capture complex on a biosensor.
      2. Inject neurturin over multiple concentrations to resolve association/dissociation.
      3. Fit kinetic/steady-state models to obtain affinity parameters.

Adjust buffers, temperature, and timing to your system, and confirm the material’s format and activity on the CoA before use.

Biological Roles

  • Literature overview (not item-specific; for scientific context)

    • Neurturin (NRTN) is a member of the GDNF family ligands (GFLs) that signals via GFRα2 (glycosylphosphatidylinositol-anchored co-receptor) in complex with RET receptor tyrosine kinase. Ligand binding promotes RET dimerization and autophosphorylation, triggering downstream cascades including MAPK/ERK, PI3K/AKT, and PLCγ pathways.
    • Neurturin supports the development and maintenance of select peripheral and central neurons, with roles in survival, neurite outgrowth, and synaptic function in experimental models. It also influences enteric nervous system biology and trophic support of specific autonomic neuron populations.
    • Specificity among GFLs is largely dictated by GFRα isoform usage (e.g., GFRα1 for GDNF, GFRα2 for neurturin), although cross-talk and context-dependent receptor pairing are documented.

  • Experimental implications

    • In cultured cells, neurturin is commonly used to study RET-dependent signaling kinetics, transcriptional programs, and phenotypic outcomes (e.g., neuritogenesis).
    • In biochemical systems, it serves as a tool to dissect ligand–receptor affinity, receptor complex assembly, and the impact of co-factors such as heparan sulfate proteoglycans.

  • Boundaries of use

    • This product is designated For research use only. No clinical, diagnostic, or therapeutic claims are made or implied.
Buffer Applications

This product is a biological ligand and not a buffering agent. It is not typically used to set or maintain pH.

  • Practical handling notes (general guidance, not item-specific)
    • Prepare and use in physiological buffers (e.g., PBS, HEPES, pH 7.2–7.5) suitable for the biological system under study.
    • If adsorption losses are a concern (particularly for protein ligands), include a minimal concentration of carrier protein (e.g., 0.1% BSA) and use low-binding plastics.
    • Filter-sterilize working solutions (0.22 µm) if sterility is required by the assay. Confirm compatibility with your readout.
Green Alternatives

This product functions as a biological ligand and is not a process solvent or bulk reagent. “Green alternatives” are therefore not typically applicable in the conventional sense.

  • Sustainable practice recommendations (general)

    • Minimize consumption by microplate miniaturization and careful titration to the minimal effective concentration.
    • Use aqueous buffers and avoid unnecessary organic cosolvents. When DMSO is required for small-molecule formats, keep final assay DMSO ≤0.1–0.5% v/v.
    • Consolidate shipments and select room-temperature shipping where validated (this SKU indicates room-temperature storage), reducing cold-chain footprint.
    • Implement reusable labware where compatible and ensure proper segregation of biohazardous and chemical waste.

  • Comparison note

    • If your workflow currently employs alternative GDNF-family ligands or recombinant proteins requiring strict cold-chain logistics, verify whether the supplied formulation of this SKU maintains activity at ambient conditions to reduce energy-intensive shipping and storage. Confirm via CoA before changing handling practices.
Pharmaceutical Uses

  • Scope of this listing

    • This product is supplied for research use only and is not intended for human or veterinary use, nor for clinical diagnostics.

  • Laboratory and development contexts (general; not item-specific)

    • As a reference ligand standard, neurturin can support discovery workflows such as receptor assay development, qualification of cell-based potency assays, and evaluation of RET pathway modulators.
    • In formulation research, knowledge gained from ligand stability screening (buffer composition, excipients, adsorption mitigation) can inform best practices for handling proteinaceous ligands in discovery settings.
    • For screening campaigns, neurturin can serve as a positive control to benchmark assay window and dynamic range in RET/GFRα2-responsive systems.

  • Regulatory note

    • No pharmacopeial monograph, dosage form, or excipient status is provided for this SKU. Any use beyond basic research requires independent regulatory assessment by the user.
Physical Properties

  • Item-specific properties

    • Appearance: Not specified for this item; refer to CoA/Spec Sheet.
    • Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
    • BP/MP/density/refractive index/UV cutoff: Not specified for this item; refer to CoA/Spec Sheet.
    • Solubility: Not specified for this item; refer to CoA/Spec Sheet.

  • Literature/General context for neurturin (not item specifications)

    • Native neurturin is a protein growth factor; proteins do not have conventional BP/MP like small molecules and are typically handled in aqueous buffers (e.g., PBS, HEPES) with carrier proteins (e.g., BSA) and reducing/antioxidant agents avoided if disulfide integrity is critical.
    • Solubility behavior depends strongly on buffer pH, ionic strength, and excipients. Typical working concentrations for protein ligands range from low pM to nM in cellular assays; stock solutions are often prepared in buffered saline with 0.1% carrier protein to minimize adsorption losses.
    • If this Moligand™ item is provided as a small-molecule surrogate/ligand, solubility may instead favor DMSO for primary stocks with subsequent dilution into assay buffer; verify on the CoA which form is supplied.

  • Practical note

    • Without an exact structure and excipient disclosure, users should conduct a small-scale solubility screen (water, buffered saline, and DMSO) and assess clarity, absence of particulates, and functional activity before scaling experiments.
Quality and Grades

  • Item-specific

    • Grade/Purity: Moligand™ (Aladdin Scientific designation). No numerical purity or stabilization system is specified for this SKU; refer to CoA/Spec Sheet for identity confirmation, lot-specific purity, and formulation details.

  • What Moligand™ generally implies (contextual, not a specification)

    • The Moligand™ line is curated for ligand–target studies, screening, and chemical biology workflows, emphasizing reliable identity, consistency across lots, and suitability for high-throughput or mechanistic assays.
    • For protein ligands, this typically involves bioactivity verification against the cognate receptor in a reference assay; for small-molecule ligands, it emphasizes identity (NMR/LC–MS) and controlled impurity profiles. Confirm which paradigm applies to SKU rp174632 on the CoA.

  • Documentation and release testing

    • Users should review the CoA for: identity method (e.g., LC–MS, SDS-PAGE, peptide mapping), purity/impurity profile, residual solvents/salts, excipients, endotoxin/bioburden (if applicable), and any potency/bioactivity metrics used for release.

  • Fit-for-purpose guidance

    • For cell-based assays, ensure matrix components (buffers/carriers) are compatible with your readout (e.g., phospho-RET ELISA, neurite outgrowth imaging) and that background from carriers is controlled.
    • For HTS use, request or establish source-plate compatibility (DMSO tolerance, precipitation limits) and stability over assay duration.
Reaction and Applications

  • Synthetic reaction chemistry

    • Not typically applicable. Neurturin is used as a biological ligand rather than as a stoichiometric reagent or catalyst in organic synthesis. For chemistry-focused work, refer instead to the Biological Roles and Application Protocols sections.

  • Research applications (literature/general; not item-specific)

    • Receptor–ligand studies: Neurturin engages GFRα2 and the RET receptor tyrosine kinase. It is widely used to interrogate RET signaling, including MAPK/ERK and PI3K/AKT pathway activation in cell culture.
    • Binding assays: Employed in radioligand or fluorescence-based binding to quantify affinity for GFRα/RET complexes or engineered receptor variants.
    • Cellular phenotyping: Used as a trophic stimulus in neuronal models to monitor neurite outgrowth, survival signaling, and transcriptional responses.
    • Selectivity profiling: Comparative studies across GDNF-family ligands (GDNF, neurturin, artemin, persephin) to define receptor usage and downstream signaling bias.

  • Practical notes (general)

    • Titrate ligand concentrations log-wise to map potency and efficacy; include vehicle and unrelated ligand controls.
    • Confirm receptor expression (e.g., via qPCR or immunoassay) to ensure responsiveness.
    • For immobilization-based studies, verify that attachment chemistry preserves the ligand’s binding surface.
Reaction Conditions

Conventional reaction-condition guidance (solvent, temperature, catalysts, yields) is not applicable because neurturin serves as a biological ligand, not a chemical reagent.

  • General assay-condition guidance (literature-based; not item-specific)

    • Cell signaling assays: Apply neurturin to GFRα2/RET-expressing cells over a log concentration range (e.g., sub-nanomolar to tens of nanomolar) to map dose–response curves. Incubation times often span 5–60 minutes for acute phosphorylation readouts and 4–24 hours for phenotypic endpoints.
    • Binding assays: Equilibrate at 4–25°C depending on format; include appropriate blockers and detergents to reduce nonspecific binding.
    • Buffering: Use neutral pH buffers (e.g., HEPES, PBS) with divalent cation conditions matched to the cell system. Avoid excessive reducing agents that might perturb disulfide bonds in protein ligands.

  • Controls and analytics

    • Include vehicle controls, unrelated GFLs, and RET inhibitors to validate pathway specificity.
    • Detect signaling with phospho-RET/ERK/AKT immunoassays or reporter systems, ensuring linear dynamic range and minimal saturation.

Always verify the exact material format (protein vs small-molecule surrogate) and consult the CoA to tailor working concentrations and diluents.

Safety and Handling

  • GHS classification (item-specific)

    • Signal word: Not specified for this item; refer to SDS.
    • Pictograms: Not specified for this item; refer to SDS.
    • Hazard statements: Not specified for this item; refer to SDS.

  • General laboratory precautions (good practice; not item-specific)

    • Handle in a well-ventilated area using standard PPE: lab coat, safety glasses, and chemical-resistant gloves.
    • Avoid aerosol generation with proteinaceous materials; prevent skin and eye contact. Wash thoroughly after handling.
    • Use clean, low-protein–binding plastics for protein ligands to minimize adsorption. For potential small-molecule formulations, prevent exposure via inhalation or ingestion and avoid contact with skin/eyes.

  • Incompatibilities and stability considerations (general)

    • Proteins may lose activity with repeated freeze–thaw or exposure to extreme pH, organic solvents, or oxidants. If the material is a small-molecule ligand dissolved in DMSO, avoid strong oxidizers and ignition sources.

  • First-aid overview (consult SDS for definitive instructions)

    • Skin/eye contact: Rinse with water for at least 15 minutes; seek medical attention if irritation persists.
    • Inhalation: Move to fresh air; obtain medical attention for symptoms.
    • Ingestion: Rinse mouth; seek medical advice.

Always consult the product-specific SDS supplied with the shipment for authoritative hazard and response guidance.

Solvent Selection

  • Item-specific solvent guidance: Not specified for this item; refer to CoA/Spec Sheet.

  • Practical route based on form (general guidance)

    • If supplied as a protein ligand: Use sterile aqueous buffers (e.g., PBS, HEPES, pH 7.2–7.5) with low-protein-binding plastics. A small amount of carrier protein (e.g., 0.1% BSA) may reduce adsorption losses; avoid reducing agents that disrupt disulfide bonds unless required by the assay.
    • If supplied as a small-molecule ligand: Prepare a concentrated DMSO stock (e.g., 10–50 mM), verify solubility and stability, then dilute into assay buffer ensuring final DMSO remains compatible with cells/enzymes (commonly ≤0.1–0.5% v/v).

  • Polarity/miscibility (context)

    • Protein forms are water-compatible; small-molecule surrogates vary—start with DMSO due to broad solvating power, then evaluate aqueous tolerance and precipitation.

  • When to choose alternatives

    • For poor aqueous stability, consider buffering with HEPES at physiological pH and include inert osmolytes (e.g., trehalose) if appropriate.
    • For small molecules with limited DMSO solubility, trial NMP or DMF as intermediate solvents, then back-dilute into assay-compatible media; validate biocompatibility.
Storage and Reconstitution

  • Item-specific

    • Storage conditions: Room temperature (per Product Data).
    • Shipped in / formulation: Not specified for this item; refer to CoA/Spec Sheet.
    • Reconstitution instructions: Not specified for this item; refer to CoA/Spec Sheet.

  • General guidance (not item-specific; tailor to CoA)

    • If supplied as a protein ligand: Reconstitute in sterile PBS or HEPES buffer (pH ~7.4), optionally with 0.1% carrier protein to reduce adsorption. Prepare single-use aliquots, avoid repeated freeze–thaw, and store working stocks at 2–8°C (short term) or −20 to −80°C (long term) if permitted by the formulation.
    • If supplied as a small-molecule ligand: Dissolve in anhydrous DMSO to a convenient stock (e.g., 10 mM), aliquot, and store tightly sealed, desiccated, and protected from light. Thaw only as needed and avoid moisture ingress.
    • Label aliquots with lot, concentration, and date; verify activity or integrity periodically using a suitable assay (e.g., phospho-RET response or LC–MS identity for small molecules).

Always follow the lot-specific CoA/SDS for authoritative storage and handling instructions for SKU rp174632.

Structure and Identity

Concise identity summary for professional users. Distinguish item-specific catalog fields from literature context.

  • Item-specific (from Product Data)

    • Product name: neurturin (SKU: rp174632)
    • CAS: rp174632 (catalog placeholder; not a standard CAS registry number)
    • Grade/Purity: Moligand™
    • Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
    • Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
    • SMILES / InChIKey: Not specified for this item; refer to CoA/Spec Sheet.

  • Literature/General identity context (for scientific orientation; not item specifications)

    • Neurturin (NRTN) is a member of the GDNF family ligands (GFLs), typically described as a secreted, cystine-knot growth factor that acts as a homodimer and signals through GFRα2 co-receptor and RET tyrosine kinase.
    • As a biologic ligand, neurturin is classically a protein; however, this Moligand™ catalog entry is positioned within a small-molecule/compound library category. Users should verify the exact chemical form and structure supplied for SKU rp174632 on the CoA.

  • Structural features (literature description of the native protein form)

    • Characteristic cystine-knot motif stabilized by multiple disulfide bonds.
    • Binds GFRα2 at the cell surface; the complex recruits/activates RET, triggering intracellular signaling (e.g., MAPK/PI3K pathways).
Synthetic Utility

Not typically applicable. Neurturin is used as a biological ligand rather than as a synthetic building block, reagent, or catalyst in organic chemistry.

  • If your objective is chemical synthesis or method development:
    • Refer instead to bioconjugation or surface immobilization strategies where neurturin (if provided as a protein) could be coupled to matrices for receptor capture or biosensing. Ensure conjugation chemistries avoid modifying residues critical for receptor binding.
    • For small-molecule surrogate ligands (if applicable), synthetic utility would rest with their role as probes rather than reagents; consult the specific small-molecule structure on the CoA to determine functional group compatibility and storage.
Target Specificity

  • Item-specific target details: Not specified for this item; refer to CoA/Spec Sheet.

  • Literature context (for orientation only; not an item specification)

    • Neurturin is the canonical ligand for GFRα2, which, in complex with RET, mediates high-affinity binding and signaling. Binding to other GFRα isoforms is generally weaker and context-dependent.

Users should confirm any target-binding data, KD/EC50 values, or cross-reactivity on the lot-specific documentation for SKU rp174632 before experimental design.

Häufig gestellte Fragen

What is Moligand??
Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.
How should this product be stored?
Store at room temperature.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

Need help choosing the grade?

Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.

View Moligand™ grade guide →
Bulk & Custom Packaging Need larger quantities or custom specifications? Contact our team for a tailored quote.
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