Nitrendipine - Moligand™, 10mM in DMSO , Gating inhibitor of Ca v1.1;Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Gating inhibitor of Ca v1.4;Channel blocker of K Ca3.1, CAS No.39562-70-4, Gating inhibitor of Ca v1.1;Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Gating inhibitor of Ca v1.4;Channel blocker of K Ca3.1

CAS: 39562-70-4 Cat. No.: N408436 Summenformel: C₁₈H₂₀N₂O₆ Molekulargewicht: 360.36 EG-Nummer: 254-513-1

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Bayotensin | 1,​4-​dihydro-​2,​6-​dimethyl-​4-​(3-​nitrophenyl)​-3,​5-​pyridinedicarboxylic acid 3-​ethyl 5-​methyl ester

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

Nitrendipine Nitrendipine (Bayotensin) is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyme

Bayotensin | 1,​4-​dihydro-​2,​6-​dimethyl-​4-​(3-​nitrophenyl)​-3,​5-​pyridinedicarboxylic acid 3-​ethyl 5-​methyl ester

Spezifikationen & Reinheit

Moligand™, 10mM in DMSO

Biochemische und physiologische Mechanismen

Nitrendipine (Bayotensin) is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

CHANNEL BLOCKER, GATING INHIBITOR

Mechanismus der Wirkung

Gating inhibitor of Ca v1.1;Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Gating inhibitor of Ca v1.4;Channel blocker of K Ca3.1

Namen und Kennungen

• Isomere SMILES: CCOC(=O)C1=C(NC(=C(C1C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC)C)C
• WGK Deutschland: 1
• RTECS: US5653000
• Molekulargewicht: 360.36
• Reaxy-Rn: 498823
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=498823&ln=

Zugehörige Ziele (menschlich)

CYP2C9 Tchem Cytochrome P450 2C9 (1 Activities)

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1C Tclin Voltage-dependent L-type calcium channel subunit alpha-1C (2 Activities)

Discover Target: CACNA1C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1D Tclin Voltage-dependent L-type calcium channel subunit alpha-1D (1 Activities)

Discover Target: CACNA1D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1F Tchem Voltage-dependent L-type calcium channel subunit alpha-1F (1 Activities)

Discover Target: CACNA1F

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1S Tclin Voltage-dependent L-type calcium channel subunit alpha-1S (1 Activities)

Discover Target: CACNA1S

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNN4 Tchem Intermediate conductance calcium-activated potassium channel protein 4 (2 Activities)

Discover Target: KCNN4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (5 Activities)

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemische und physikalische Eigenschaften

• Schmelzpunkt (°C): 159 °C

Referenzen

1. Xiuling Tang, Huanhuan Zhao, Wei Jiang, Song Zhang, Shun Guo, Xiaobo Gao, Peng Yang, Lei Shi, Linna Liu.  (2018)  Pharmacokinetics and pharmacodynamics of citrus peel extract in lipopolysaccharide-induced acute lung injury combined with Pinelliae Rhizoma Praeparatum.  Food & Function,  9  (11): (5880-5890).  [PMID:30374490] [10.1039/C8FO01337C]

2. Huilin Ma, Yunmei Li, Huan Shi, Biaobiao Wang, He Tian, Xifan Mei, Chao Wu.  (2025)  Berberine‑calcium alginate-coated macrophage membrane-derived nanovesicles for the oral treatment of ulcerative colitis.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39755317] [10.1016/j.ijbiomac.2024.139114]

3. Yunmei Li, Huilin Ma, Huan Shi, Biaobiao Wang, Desheng Li, He Tian, Xifan Mei, Chao Wu.  (2025)  Dextran sulfate-coated curcumin nanocrystals for the treatment of DSS-induced ulcerative colitis in mice.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:40043963] [10.1016/j.ijpharm.2025.125428]