Nomifensine maleate is a selective dopamine uptake inhibitor interacting with the dopamine transporter, at a site different from that of cocaine; antidepressant. Nomifensine serves as an antidepressant and is known to cause frequent hemolytic anemia. The aniline group in this compound results in blood and liver toxicities.

Specifications

Synonyme

Spezifikationen & Reinheit

≥98%

Biochemische und physiologische Mechanismen

Potent inhibitor of noradrenalin and dopamine uptake (Kivalues are 4.7, 26 and 4000 nM for inhibition of noradrenalin, dopamine and 5-HT uptake respectively, in rat brain). Increases central dopamine levels in rats following systemic administration. Displ

Storage

Store at 2-8°C

Verschickt in

Wet ice

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Reinheit

≥98%

Namen und Kennungen

Pubchem Sid	504763695
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504763695
Kanonisches Lächeln	CN1CC(C2=C(C1)C(=CC=C2)N)C3=CC=CC=C3.C(=CC(=O)O)C(=O)O
IUPAC Name	(Z)-but-2-enedioic acid;2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine
InChIKey	GEOCVSMCLVIOEV-BTJKTKAUSA-N
INCHI	1S/C16H18N2.C4H4O4/c1-18-10-14(12-6-3-2-4-7-12)13-8-5-9-16(17)15(13)11-18;5-3(6)1-2-4(7)8/h2-9,14H,10-11,17H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
Isomere SMILES	CN1CC(C2=C(C1)C(=CC=C2)N)C3=CC=CC=C3.C(=C\C(=O)O)\C(=O)O
WGK Deutschland	3
RTECS	NX4912800
Molekulargewicht	354.40
Reaxy-Rn	23011294
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=23011294&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

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✅ Certificate of Analysis (COA)

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📊 Datasheet

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🔬 Specification Sheet

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Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Klasse Tetrahydroisoquinolines
    - Subclass 4-phenyltetrahydroisoquinolines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Klasse	Tetrahydroisoquinolines
Subclass	4-phenyltetrahydroisoquinolines
Intermediate Tree Nodes	Not available
Direct Parent	4-phenyltetrahydroisoquinolines
Alternative Parents	Aminoquinolines and derivatives Aralkylamines Unsaturated fatty acids Dicarboxylic acids and derivatives Benzene and substituted derivatives Trialkylamines Carboxylic acids Azacyclic compounds Primary amines Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Not available
Substituents	4-phenyltetrahydroisoquinoline - Aminoquinoline - Aralkylamine - Monocyclic benzene moiety - Dicarboxylic acid or derivatives - Unsaturated fatty acid - Benzenoid - Fatty acyl - Fatty acid - Tertiary amine - Tertiary aliphatic amine - Carboxylic acid - Carboxylic acid derivative - Azacycle - Amine - Organic nitrogen compound - Primary amine - Organooxygen compound - Organonitrogen compound - Organic oxide - Carbonyl group - Organopnictogen compound - Organic oxygen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
Beschreibung	This compound belongs to the class of organic compounds known as 4-phenyltetrahydroisoquinolines. These are compounds containing a phenyl group attached to the C4-atom of a tetrahydroisoquinoline moiety.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D-Struktur

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KCNH2 Tclin HERG (29587 Activities)

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POLB Tchem DNA polymerase beta (23632 Activities)

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GLA Tclin Alpha-galactosidase A (5444 Activities)

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PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

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SMN1 Tchem Survival motor neuron protein (34246 Activities)

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LMNA Tbio Prelamin-A/C (36751 Activities)

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PABPC1 Tbio Polyadenylate-binding protein 1 (2615 Activities)

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PMP22 Tbio Peripheral myelin protein 22 (699 Activities)

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KMT2A Tchem Histone-lysine N-methyltransferase MLL (17327 Activities)

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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

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CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

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SENP1 Tchem Sentrin-specific protease 1 (681 Activities)

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MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

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TARDBP Tchem TAR DNA-binding protein 43 (40113 Activities)

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Mapk1 MAP kinase ERK2 (650 Activities)

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Plasmodium falciparum (966862 Activities)

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FTL Ferritin light chain (43324 Activities)

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nfo Endonuclease 4 (425 Activities)

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NS1 Nonstructural protein 1 (33327 Activities)

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Wirkungsmechanismen

Zertifikate (CoA, COO, BSE/TSE und Analyse-Diagramm)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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6 results found

Lot Number	Certificate Type	Datum	Artikel
A2309216	Certificate of Analysis	Jul 07, 2026	N133375
A2309214	Certificate of Analysis	Jul 07, 2026	N133375
A2309151	Certificate of Analysis	Jul 07, 2026	N133375
A2622051	Certificate of Analysis	Jan 28, 2026	N133375
C2514299	Certificate of Analysis	Mar 21, 2025	N133375
G2404070	Certificate of Analysis	Jul 11, 2022	N133375

Chemische und physikalische Eigenschaften

Löslichkeit	Solvent:DMSO, Max Conc. mg/mL: 35.44, Max Conc. mM: 100
Empfindlichkeit	Moisture sensitive
Molekulargewicht	354.400 g/mol
XLogP3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	3
Exact Mass	354.158 Da
Monoisotopic Mass	354.158 Da
Topological Polar Surface Area	104.000 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	391.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	2

Lösungsrechner

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Nomifensine - ≥98% , CAS No.32795-47-4

Why this grade

Storage & shipping

Quality documents

Literature proof

Übersicht