Moligand™,10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Nrf2-IN-1 is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2) . Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML)
In Vitro
Nrf2-IN-1 (Compound 4f) (10 μM) inhibits Nrf2 activation. ?\nNrf2-IN-1(1-20 μM; 48 hours) inhibits growth of the three AML cell. ?\nNrf2-IN-1 (5-10 μM; 48 hours) induces apoptosis of three AML cells in vitro. ?\nNrf2-IN-1 induces apoptotic signaling involving Bcl-2 and Bax. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: THP-1 cells, HL-60 cells, U937 cells Concentration: 1 μM, 5 μM, 10 μM, 20 μM Incubation Time: 48 hours Result: Inhibited growth of the three AML cell types at 5 μM, 10 μM or 20 μM for 48 hours. Apoptosis AnalysisCell Line: THP-1 cells, HL-60 cells, U937 cells Concentration: 5 μM, 10 μM Incubation Time: 48 hours Result: Induced apoptosis in AML cells in vitro. Western Blot AnalysisCell Line: THP-1 cells, HL-60 cells, U937 cells Concentration: 5 μM, 10 μM Incubation Time: 48 hours Result: Triggered caspase-dependent apoptotic signaling in AML cells.
In Vivo
Nrf2-IN-1 inhibits tumor growth via apoptosis in chicken eggs . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:Nrf2
| Isomeric SMILES | CC(C)(C)C1=CC=C(C=C1)CN2C(=CC(=N2)C3=CC=C(C=C3)Cl)C(=O)NO |
|---|---|
| PubChem CID | 76900951 |
| Molecular Weight | 383.87 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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