NRX-103094 - ≥99% , CAS No.2763260-36-0

CAS: 2763260-36-0 Cat. No.: N651780 Summenformel: C₂₀H₁₁Cl₂F₃N₂O₄S Molekulargewicht: 503.28

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

NRX-103094 is a potent enhancer of the interaction between β-catenin , and its cognate E3 ligase , SCF β-TrCP . NRX-103094 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC 50 of 62 nM and a K d of 0.6 nM

In Vitro

NRX-103094 shows high potency with pSer33/Ser37 β-catenin peptide (EC 50 of 457 nM). NRX-103094 potentiates the ubiquitylation of pSer33/S37A β-catenin peptide to levels greater than wild-type pSer33/pSer37 levels at 250 nM. NRX-103094 enhances the S33E/S37A phosphomimetic peptide binding affinity for β-TrCP from >5 μM in the absence of compound to 22 nM in the presence of 40 μM compound. In the presence of 20 μM NRX-103094, robust time-dependent ubiquitylation of S33E/S37A β-catenin peptide is observed. Likewise, the full-length S33E/S37A β-catenin protein is strongly ubiquitylated in the presence of 20 μM NRX-103094, with the ubiquitylation levels approaching that of WT full-length β-catenin protein. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:EC50: 62 nM (β-catenin:β-TrCP Interaction), Kd: 0.6 nM (β-catenin:β-TrCP Interaction)

Specifications

Spezifikationen & Reinheit

≥99%

Biochemische und physiologische Mechanismen

NRX-103094 is a potent enhancer of the interaction between β-catenin , and its cognate E3 ligase , SCF β-TrCP . NRX-103094 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC 50 of 62 nM and a K d of 0.6 nM.

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Reinheit

≥99%

Namen und Kennungen

Molekulargewicht

503.28

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2763260-36-0, the molecular formula is C20H11Cl2F3N2O4S, and the molecular weight is 503.28 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.