NRX-252262 - ≥99% , CAS No.2438637-61-5

CAS: 2438637-61-5 Cat. No.: N647521 Summenformel: C₂₃H₁₇Cl₂F₃N₂O₄S Molekulargewicht: 545.36 PubChem CID: 138319682

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

NRX-252262 is a potent enhancer of the interaction between β-Catenin , and its cognate E3 ligase , SCF β-TrCP , induces mutant β-catenin degradation, with an EC 50 of 3.8 nM

In Vitro

NRX-252262 (35 μM) causes S33E/S37A mutant β-catenin degradation in cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:EC50: 3.8 nM (β-Catenin-SCF β-TrCP )

Specifications

Spezifikationen & Reinheit

≥99%

Biochemische und physiologische Mechanismen

NRX-252262 is a potent enhancer of the interaction between β-Catenin , and its cognate E3 ligase , SCF β-TrCP , induces mutant β-catenin degradation, with an EC 50 of 3.8 nM.

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Reinheit

≥99%

Namen und Kennungen

Kanonisches Lächeln

COC1=C(C=C2CN(CC2=C1)C(=O)C3=C(C=C(NC3=O)C(F)(F)F)SC4=C(C=CC=C4Cl)Cl)OC

IUPAC Name

4-(2,6-dichlorophenyl)sulfanyl-3-(5,6-dimethoxy-1,3-dihydroisoindole-2-carbonyl)-6-(trifluoromethyl)-1H-pyridin-2-one

InChIKey

SPAYLOCXFWJEBL-UHFFFAOYSA-N

INCHI

1S/C23H17Cl2F3N2O4S/c1-33-15-6-11-9-30(10-12(11)7-16(15)34-2)22(32)19-17(8-18(23(26,27)28)29-21(19)31)35-20-13(24)4-3-5-14(20)25/h3-8H,9-10H2,1-2H3,(H,29,31)

PubChem CID

138319682

Molekulargewicht

545.36

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organosulfur compounds
    • Klasse Thioethers
      • Subclass Aryl thioethers

• Kingdom: Organic compounds
• Superclass: Organosulfur compounds
• Klasse: Thioethers
• Subclass: Aryl thioethers
• Intermediate Tree Nodes: Not available
• Direct Parent: Diarylthioethers
• Alternative Parents: Pyridinecarboxylic acids and derivatives Isoindolines Thiophenol ethers Polyhalopyridines Anisoles Pyridinones Methylpyridines Chlorobenzenes Alkyl aryl ethers 2-halopyridines Vinylogous thioesters N-acyl amines Vinylogous amides Tertiary carboxylic acid amides Heteroaromatic compounds Lactams Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organofluorides Organochlorides Organic oxides Hydrocarbon derivatives Alkyl fluorides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Diarylthioether - Pyridine carboxylic acid or derivatives - Isoindole or derivatives - Isoindoline - Polyhalopyridine - Thiophenol ether - Anisole - 2-halopyridine - Methylpyridine - Pyridinone - Halobenzene - Chlorobenzene - Alkyl aryl ether - Vinylogous thioester - Benzenoid - Pyridine - N-acyl-amine - Monocyclic benzene moiety - Heteroaromatic compound - Vinylogous amide - Tertiary carboxylic acid amide - Lactam - Carboxamide group - Azacycle - Organoheterocyclic compound - Ether - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organofluoride - Organochloride - Organohalogen compound - Alkyl halide - Alkyl fluoride - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as diarylthioethers. These are organosulfur compounds containing a thioether group that is substituted by two aryl groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO : 8.33 mg/mL (15.27 mM; Need ultrasonic)
• Molekulargewicht: 545.400 g/mol
• XLogP3: 4.800
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 544.024 Da
• Monoisotopic Mass: 544.024 Da
• Topological Polar Surface Area: 93.200 Ų
• Heavy Atom Count: 35
• Formal Charge: 0
• Complexity: 886.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2438637-61-5, the molecular formula is C23H17Cl2F3N2O4S, and the molecular weight is 545.36 g/mol. InChIKey SPAYLOCXFWJEBL-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.