NS 383 - Moligand™ , Channel blocker of ASIC1;Channel blocker of ASIC3, CAS No.309711-59-9, Channel blocker of ASIC1;Channel blocker of ASIC3

CAS: 309711-59-9 Cat. No.: N288698 Molecular Weight: 321.37 PubChem CID: 135418391

GRADE & PURITY Moligand™

Synonyms

8-Ethyl-6,7,8,9-tetrahydro-5-phenyl-1H-pyrrolo[3,2-h]isoquinoline-2,3-dione-3-oxime

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonyms

8-Ethyl-6, 7, 8, 9-tetrahydro-5-phenyl-1H-pyrrolo[3, 2-h]isoquinoline-2, 3-dione-3-oxime

Specifications & Purity

Moligand™

Biochemical and Physiological Mechanisms

ASIC blocker (IC50values are 0.44, 2.1 μM and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC50value = 0.12 μM at human ASIC1a with no effect at ASIC2a or ASIC3). Inhibition was also observed at heteromeric ASIC channels (IC50values are 0.79,

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

CHANNEL BLOCKER

Mechanism of action

Channel blocker of ASIC1;Channel blocker of ASIC3

Names and Identifiers

• Canonical Smiles: CCN1CCC2=C(C=C3C(=C2C1)NC(=C3N=O)O)C4=CC=CC=C4
• IUPAC Name: 8-ethyl-3-nitroso-5-phenyl-1,6,7,9-tetrahydropyrrolo[3,2-h]isoquinolin-2-ol
• InChIKey: OZVZKENYKWSYBC-UHFFFAOYSA-N
• INCHI: 1S/C19H19N3O2/c1-2-22-9-8-13-14(12-6-4-3-5-7-12)10-15-17(16(13)11-22)20-19(23)18(15)21-24/h3-7,10,20,23H,2,8-9,11H2,1H3
• PubChem CID: 135418391
• Molecular Weight: 321.37

Associated Targets(Human)

ASIC3 Tchem Acid-sensing ion channel 3 (0 Activities)

Discover Target: ASIC3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ASIC1 Tchem Acid-sensing ion channel 1 (0 Activities)

Discover Target: ASIC1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 1.61, Max Conc. mM: 5