≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
NT157 NT157, a selective inhibitor of IRS-1/2(insulin receptor substrate) , has the potential to inhibit IGF-1R and STAT3 signaling pathways in cancer cells and stroma cells of TME leading to a decrease in cancer cell survival.
Targets
IRS1/2
In vitro
NT157 treatment resulted in dose-dependent inhibition of IGF1R activation, suppression of IRS protein expression, inhibition of IGF1-induced AKT activation, but increased ERK activation in NT157-treated cells in vitro. These effects were correlated with decreased proliferation and increasing apoptosis of LNCaP cells and increasing G2-M arrest in PC3 cells. NT157 can mediate suppression of IGF1R-mediated survival signaling through the established mechanism for negative feedback of IGF1R signaling: targeting IRS1/2 for serine phosphorylation and subsequent degradation. NT157 displayed little to no effect on the survival of normal melanocytes and fibroblasts.
In vivo
NT157 suppressed androgen-responsive growth, delayed CRPC progression of LNCaP xenografts, and suppressed PC3 tumor growth alone and in combination with docetaxel. Melanoma tumor growth and metastasis is efficiently inhibited by NT157.
Cell Research(from reference)
Cell lines：LNCaP cells, PC3 cells
Concentrations：0-10 μM
Incubation Time：72 h
| ALogP | 3.721 |
|---|---|
| HBD-Zahl | 6 |
| Rotationsfähige Bindung | 5 |
| Pubchem Sid | 528766347 |
|---|---|
| Kanonisches Lächeln | C1=C(C=C(C(=C1O)O)O)CNC(=S)C=CC2=CC(=C(C(=C2)Br)O)O |
| IUPAC Name | (E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-[(3,4,5-trihydroxyphenyl)methyl]prop-2-enethioamide |
| InChIKey | NIPUPOUEGOSAAO-OWOJBTEDSA-N |
| INCHI | 1S/C16H14BrNO5S/c17-10-3-8(4-11(19)15(10)22)1-2-14(24)18-7-9-5-12(20)16(23)13(21)6-9/h1-6,19-23H,7H2,(H,18,24)/b2-1+ |
| Isomere SMILES | C1=C(C=C(C(=C1O)O)O)CNC(=S)/C=C/C2=CC(=C(C(=C2)Br)O)O |
| Molekulargewicht | 412.26 |
| Reaxy-Rn | 22688869 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=22688869&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
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View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Klasse | Phenols |
| Subclass | Benzenetriols and derivatives |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Pyrogallols and derivatives |
| Alternative Parents | Styrenes O-bromophenols M-bromophenols Catechols Bromobenzenes 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Aryl bromides Thioamides Thiocarboxylic acid amides Polyols Thiocarbonyl compounds Organopnictogen compounds Organonitrogen compounds Organobromides Hydrocarbon derivatives |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Pyrogallol derivative - Styrene - 2-bromophenol - 3-bromophenol - 2-halophenol - 3-halophenol - Catechol - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Halobenzene - Bromobenzene - Monocyclic benzene moiety - Aryl halide - Aryl bromide - Thioamide - Thiocarboxylic acid amide - Polyol - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Thiocarbonyl group - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organobromide - Organohalogen compound - Aromatic homomonocyclic compound |
| Beschreibung | This compound belongs to the class of organic compounds known as pyrogallols and derivatives. These are compounds containing a 1,2,3-trihydroxybenzene moiety. |
| External Descriptors | Not available |
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Datum | Artikel |
|---|---|---|---|
 A2426262 | Certificate of Analysis | Dec 25, 2023 | N413949 |
| A2426263 | Certificate of Analysis | Dec 25, 2023 | N413949 |
| A2426264 | Certificate of Analysis | Dec 25, 2023 | N413949 |
| A2426265 | Certificate of Analysis | Dec 25, 2023 | N413949 |
| A2426266 | Certificate of Analysis | Dec 25, 2023 | N413949 |
| A2426267 | Certificate of Analysis | Dec 25, 2023 | N413949 |
| A2426268 | Certificate of Analysis | Dec 25, 2023 | N413949 |
| A2426269 | Certificate of Analysis | Dec 25, 2023 | N413949 |
| A2426271 | Certificate of Analysis | Dec 25, 2023 | N413949 |
| A2426272 | Certificate of Analysis | Dec 25, 2023 | N413949 |
| Löslichkeit | Solubility (25°C) In vitro DMSO: 82 mg/mL (198.9 mM); Ethanol: 82 mg/mL (198.9 mM); Water: Insoluble; |
|---|---|
| DMSO (mg/ml) Maximale Löslichkeit | 82 |
| DMSO (mM) Maximale Löslichkeit | 198.9036045 |
| Wasser (mg/ml) Maximale Löslichkeit | ＜1 |
| Molekulargewicht | 412.300 g/mol |
| XLogP3 | 2.600 |
| Hydrogen Bond Donor Count | 6 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 4 |
| Exact Mass | 410.978 Da |
| Monoisotopic Mass | 410.978 Da |
| Topological Polar Surface Area | 145.000 Ų |
| Heavy Atom Count | 24 |
| Formal Charge | 0 |
| Complexity | 454.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 1 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 1 |
| Covalently-Bonded Unit Count | 1 |
