ODM-203 - ≥99% , CAS No.1430723-35-5

CAS: 1430723-35-5 Cat. No.: O414242 Summenformel: C₂₆H₂₁F₂N₅O₂S Molekulargewicht: 505.54

GRADE & PURITY ≥99%

Synonyms

1430723-35-5 | AKOS040759188 | 1814961-19-7 | s8882 | ZJFCBQXPTQSTCZ-UHFFFAOYSA-N | N-(2',4'-Difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl)(1,1'-biphenyl)-3-yl)cyclopropanesulfonamide | Cyclopropanesulfonamide, N-(2',4'-difluoro-5-(5-(1-me

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

Information

ODM-203 is a selective inhibitor ofFGFRandVEGFRwith ic50s of 11 nM,16 nM,6 nM, 35 nM,26 nM,9 nM,5 nM for recombinant FGFR1, FGFR2, FGFR3,FGFR4, VEGFR1, VEGFR2 and VEGFR3, respectively.

Targets

VEGFR3 (Cell-free assay); FGFR3 (Cell-free assay); VEGFR2 (Cell-free assay); FGFR1 (Cell-free assay); FGFR2 (Cell-free assay) 32053,5 nM; 6 n

In vitro

In cellular assays, ODM-203 inhibits VEGFR-induced tube formation (IC50 33 nmol/L) with similar potency as it inhibits proliferation in FGFR-dependent cell lines such as H1581,SNU16,and RT4 cells (IC50 50-150 nmol/L).

In vivo

ODM-203 shows strong antitumor activity in both FGFR-dependent xenograft models and in an angiogenic xenograft model at similar well-tolerated doses.

Cell Research(from reference)

Cell lines：H1581,SNU16,and RT4 cells 

Concentrations：up to 3 μmol/L 

Incubation Time：96 h 

Specifications

Synonyme

1430723-35-5 | AKOS040759188 | 1814961-19-7 | s8882 | ZJFCBQXPTQSTCZ-UHFFFAOYSA-N | N-(2',4'-Difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl)(1,1'-biphenyl)-3-yl)cyclopropanesulfonamide | Cyclopropanesulfonamide, N-(2',4'-difluoro-5-(5-(1-me

Spezifikationen & Reinheit

≥99%

Biochemische und physiologische Mechanismen

ODM-203 is a selective inhibitor of FGFR and VEGFR with ic50s of 11 nM,16 nM,6 nM, 35 nM,26 nM,9 nM,5 nM for recombinant FGFR1, FGFR2, FGFR3,FGFR4, VEGFR1, VEGFR2 and VEGFR3, respectively.

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Reinheit

≥99%

Produkteigenschaften

• ALogP: 4.626
• hba_count: 4
• HBD-Zahl: 1
• Rotationsfähige Bindung: 6

Namen und Kennungen

• Pubchem Sid: 504772157
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504772157
• Kanonisches Lächeln: CN1C=C(C=N1)C2=CC3=C(C=C2)N(C=N3)C4=CC(=CC(=C4)NS(=O)(=O)C5CC5)C6=C(C=C(C=C6)F)F
• IUPAC Name: N-[3-(2,4-difluorophenyl)-5-[5-(1-methylpyrazol-4-yl)benzimidazol-1-yl]phenyl]cyclopropanesulfonamide
• InChIKey: ZJFCBQXPTQSTCZ-UHFFFAOYSA-N
• INCHI: 1S/C26H21F2N5O2S/c1-32-14-18(13-30-32)16-2-7-26-25(10-16)29-15-33(26)21-9-17(23-6-3-19(27)11-24(23)28)8-20(12-21)31-36(34,35)22-4-5-22/h2-3,6-15,22,31H,4-5H2,1H3
• Isomere SMILES: CN1C=C(C=N1)C2=CC3=C(C=C2)N(C=N3)C4=CC(=CC(=C4)NS(=O)(=O)C5CC5)C6=C(C=C(C=C6)F)F
• Molekulargewicht: 505.54
• Reaxy-Rn: 24250974
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24250974&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Klasse Benzimidazoles
      • Subclass Phenylbenzimidazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Klasse: Benzimidazoles
• Subclass: Phenylbenzimidazoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylbenzimidazoles
• Alternative Parents: Biphenyls and derivatives Phenylimidazoles Sulfanilides Fluorobenzenes Aryl fluorides Organosulfonamides N-substituted imidazoles Organic sulfonamides Heteroaromatic compounds Aminosulfonyl compounds Pyrazoles Azacyclic compounds Hydrocarbon derivatives Organic oxides Organofluorides Organonitrogen compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phenylbenzimidazole - Biphenyl - 1-phenylimidazole - Sulfanilide - Fluorobenzene - Halobenzene - Benzenoid - Organosulfonic acid amide - Organic sulfonic acid amide - Aryl halide - Monocyclic benzene moiety - Aryl fluoride - N-substituted imidazole - Aminosulfonyl compound - Sulfonyl - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Heteroaromatic compound - Pyrazole - Azole - Imidazole - Azacycle - Hydrocarbon derivative - Organohalogen compound - Organofluoride - Organic nitrogen compound - Organonitrogen compound - Organosulfur compound - Organic oxygen compound - Organic oxide - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as phenylbenzimidazoles. These are compounds containing a phenylbenzimidazole skeleton, which consists of a benzimidazole moiety where its imidazole ring is attached to a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

FGFR1 Tclin Fibroblast growth factor receptor 1 (1 Activities)

Discover Target: FGFR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FGFR2 Tclin Fibroblast growth factor receptor 2 (3405 Activities)

Discover Target: FGFR2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FGFR1 Tclin Fibroblast growth factor receptor 1 (9149 Activities)

Discover Target: FGFR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FLT1 Tclin Vascular endothelial growth factor receptor 1 (6262 Activities)

Discover Target: FLT1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)

Discover Target: KDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FLT4 Tclin Vascular endothelial growth factor receptor 3 (3216 Activities)

Discover Target: FLT4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RT-4 (268 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Zugehörige Ziele (nicht menschlich)

Fgfr4 Fibroblast growth factor receptor 4 (138 Activities)

Discover Target: Fgfr4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)

Discover Target: Fgfr3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro DMSO: 100 mg/mL (197.8 mM); Water: Insoluble; Ethanol: Insoluble
• DMSO (mg/ml) Maximale Löslichkeit: 100
• DMSO (mM) Maximale Löslichkeit: 197.808284210943
• Wasser (mg/ml) Maximale Löslichkeit: ＜1
• Molekulargewicht: 505.500 g/mol
• XLogP3: 4.400
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 6
• Exact Mass: 505.138 Da
• Monoisotopic Mass: 505.138 Da
• Topological Polar Surface Area: 90.200 Ų
• Heavy Atom Count: 36
• Formal Charge: 0
• Complexity: 886.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Application Protocols

No tested application protocols are provided in the Product Data for ODM-203.

General, non-item-specific starting points used for bioactive small molecules:

• Stock preparation: Dissolve in anhydrous DMSO to prepare a concentrated stock; vortex and, if needed, sonicate briefly. Record the exact mass and volume for accurate concentration tracking.
• Cell-based assays: Titrate across a concentration range with vehicle controls. Maintain low final DMSO (commonly ≤0.1–0.5% v/v). Monitor compound precipitation in culture media.
• Biochemical assays: Include appropriate ATP concentrations and Mg2+ for kinase assays; define incubation times and temperature to reach steady-state or desired time points.
• Stability checks: Assess freeze–thaw tolerance of DMSO stocks and short-term stability in assay buffer by LC–MS or HPLC.

Because no item-specific protocols are validated here, optimize conditions for your assay and consult the SDS/CoA for any handling constraints.

Biological Roles

ODM-203 is supplied for research use only as a bioactive small molecule. While item-specific mechanistic annotations are not provided in the Product Data, ODM-203 is broadly referenced in the literature as a kinase pathway modulator, and is used to interrogate signaling networks in cells and biochemical systems. No medical or clinical claims are made.

Research contexts where ODM-203-type tool compounds are commonly applied (literature-based, not item-specific specifications):

• Kinase pathway interrogation: Probe-dependent modulation of receptor tyrosine kinase signaling with downstream effects on MAPK/ERK, PI3K/AKT, and related pathways. Determine exact target profile from primary references before experimental design.
• Target engagement assays: CETSA, NanoBRET, or ELISA-based phospho-protein readouts to quantify on-target activity in live cells or lysates.
• Selectivity profiling: Broad kinome panels or focused enzyme assays to benchmark potency and selectivity under defined ATP concentrations; confirm assay buffer composition and enzyme sources.
• ADME/stability studies: In vitro metabolic stability (microsomes/hepatocytes), permeability (PAMPA/Caco-2), and plasma protein binding to support pharmacology research.

Important cautions:

• Off-target activity may occur at higher concentrations; titrate carefully and include vehicle controls.
• Validate with orthogonal readouts (biochemistry and cell biology) and, where possible, structure-activity relationships from the literature for ODM-203.

Buffer Applications

ODM-203 is not a buffer component. However, buffer selection is critical for preparing working solutions for biochemical or cell-based assays.

General, non-item-specific guidance:

• Vehicle control: Prepare concentrated DMSO stock; dilute into assay buffer ensuring final DMSO is typically ≤0.1–0.5% v/v, as tolerated by the system.
• Common assay buffers: PBS, HBSS, HEPES-buffered saline, or Tris-based buffers. Include 0.1–0.5% BSA when nonspecific binding or precipitation is observed.
• pH and ionic strength: Maintain physiological pH (7.2–7.6) for cell assays; confirm compound stability across the intended pH range.
• Surfactants: Low levels of Tween-20 or Pluronic F-68 can help maintain homogeneity in high-throughput formats; validate for assay interference.

Note: No item-specific buffer recipes or pKa values are provided for ODM-203 in the Product Data; consult CoA/primary literature for stability constraints before deviating from standard assay buffers.

Green Alternatives

This product is a bioactive tool compound rather than a process solvent or reagent used in bulk transformations; therefore, green-chemistry substitution analysis is generally not applicable.

Where sustainability considerations can still apply:

• Solvent choice for stocks: Prefer lower-toxicity, lower-volume use of DMSO and aqueous dilutions; minimize halogenated solvents in sample prep.
• Waste minimization: Use microvolume assay formats and plate-based screening to reduce chemical and solvent waste.
• Analytical methods: Adopt UHPLC to reduce solvent consumption relative to HPLC; consider water-rich mobile phases when compatible with the analyte.

If ODM-203 is used in synthetic method development or as an analytical standard in larger volumes, apply institutional green-chemistry guidelines for solvent ranking and waste handling.

Pharmaceutical Uses

No clinical or therapeutic claims are made for this product. ODM-203 is provided strictly for research use only.

Relevant non-clinical, laboratory uses (general guidance; not item-specific specifications):

• Reference/working standard: For analytical method development and qualification (e.g., LC–MS/MS quantification in matrices), forced-degradation studies, and stability-indicating method validation. Confirm reference purity and form from the CoA before use in regulated environments.
• Formulation research: Solubility screening, salt/cocrystal exploration, and excipient compatibility studies to support preclinical formulation development. Item-specific form (free base/salt/solvate) is not provided here and should be verified.
• In vitro pharmacology: Standardized dosing solutions for enzyme and cell assays, including concentration–response and time-course experiments with rigorous vehicle controls.
• Impurity/metabolite tracking: Use as a comparator in biotransformation studies and as a retention-time/fragmentation benchmark during mass spectrometric analysis.

Regulatory context:

• No pharmacopeial monograph or compendial status is provided in the Product Data. For regulated work, obtain and file the lot-specific CoA, SDS, and any available traceability documents.

Physical Properties

Item-specific physicochemical specifications are not provided in the Product Data for ODM-203. Do not use inferred values as specifications.

Item-specific specs:

• Appearance: Not specified for this item; refer to CoA/Spec Sheet.
• Melting point, boiling point, density, refractive index, UV cutoff, logP, pKa, water/peroxide/metal limits: Not specified for this item; refer to CoA/Spec Sheet.

General/literature guidance (non-spec; verify for your lot):

• Kinase inhibitors of this class are often crystalline solids with low aqueous solubility and good solubility in polar aprotic organic solvents (e.g., DMSO). ODM-203 is commonly handled as concentrated DMSO stocks for in vitro assays, then diluted into aqueous buffers containing carrier protein or co-solvent.
• Aqueous solubility, if limited, can sometimes be enhanced by pH adjustment (if ionizable moieties exist) or by using co-solvents/surfactants; however, exact ionization behavior (pKa) for ODM-203 must be taken from primary references or your CoA.

Practical note:

• For analytical development (HPLC/LC–MS), start with DMSO stock solutions and dilute into mobile phase; screen reversed-phase methods (C18) with gradients. Retention and detection parameters should be optimized empirically because item-specific UV/fluorescence properties are not provided here.

Quality and Grades

Item-specific grade and purity are not provided in the Product Data for ODM-203.

• Grade/Purity (item-specific): Not specified for this item; refer to CoA/Spec Sheet.

General guidance on grades for bioactive small molecules (contextual, not item-specific):

• Research grade: Intended for discovery research; typical expectations include identity confirmation (e.g., NMR/HRMS), and purity suitable for biological assays (often ≥95% by HPLC/UPLC), but exact criteria must be verified on the CoA for this SKU.
• Analytical reference standard grade: Emphasizes assay traceability, documented purity, and stability data for method development and QC; if needed, request an analytical reference standard specification.
• Stabilizers/Counterions: Some small molecules are provided as free base, salt, or solvate; confirm the exact form on the CoA, as form can impact solubility, potency, and molecular weight calculations.

What to check prior to use:

• Confirm the lot-specific purity assay method (e.g., HPLC/UPLC conditions) and result.
• Verify water content/residual solvent only if provided on the CoA; not specified here.
• Review recommended reconstitution solvent and any stated stabilizers/antioxidants (none are specified in the present Product Data).

Reaction and Applications

ODM-203 is not typically employed as a synthetic reagent or catalyst. It is a bioactive small molecule used as a tool compound in chemical biology and pharmacology research.

• Synthetic reactions (e.g., Grignard, cross-coupling, oxidations) are not relevant to the routine use of ODM-203 as supplied. If you are synthesizing ODM-203 or analogs, consult the primary medicinal chemistry literature for route design and reaction choices.
• Applicable laboratory applications center on biological evaluation: target engagement studies, pathway mapping, chemical probe validation, and method development in analytical chemistry (e.g., LC–MS quantitation, stability-indicating methods).
• For assay development, consider compound handling parameters (vehicle, final DMSO %, adsorption) rather than reaction chemistry.

Pointer to relevant sections:

• See “Biological Roles,” “Pharmaceutical Uses,” and “Application Protocols” (if available) for guidance on deploying ODM-203 in research settings.

Reaction Conditions

Not applicable. ODM-203 is supplied as a bioactive research compound, not as a reagent for performing chemical reactions.

For researchers synthesizing ODM-203 or structural analogs (general, literature-oriented remarks):

• Solvents: Polar aprotic media (DMF, DMSO, NMP, dioxane) are frequently used for cross-couplings and aminations on heteroaromatics.
• Catalysts/Bases: Pd(0/II) catalysts with phosphine ligands for Suzuki/Buchwald–Hartwig; carbonate or tertiary amine bases are common. Copper-mediated N-arylations are also seen for some scaffolds.
• Temperatures: 60–120 °C (oil bath or sealed-vessel) depending on step; microwave heating can shorten cycle times.
• Workup: Aqueous quench followed by extraction when possible; otherwise, direct adsorption onto reversed-phase media for chromatographic purification.

These are general conditions for heteroaryl chemistry and are not specific to ODM-203 as sold.

Safety and Handling

Safety details are not fully specified in the Product Data for this item. Always consult the product SDS for authoritative guidance.

From Product Data:

• GHS Classification / Pictograms / Signal Word / H-Statements: Not specified for this item; refer to SDS.
• Storage Conditions: Store at −20 °C.
• Shipping: Ice chest + ice pads.

General laboratory handling guidance for research-use-only small molecules:

• PPE: Laboratory coat, nitrile gloves, and safety glasses as baseline. Use chemical-resistant gloves appropriate to the solvent system (e.g., DMSO) when preparing stocks.
• Engineering controls: Work in a chemical fume hood when weighing powders and preparing solutions. Avoid aerosol or dust formation.
• Incompatibilities: Avoid strong oxidizers and strong acids/bases unless compatibility is known. Do not heat or atomize solutions.
• Hygiene measures: Avoid ingestion, inhalation, and skin contact. Wash thoroughly after handling. Decontaminate benches and tools after use.
• First-aid (overview; defer to SDS): In case of skin/eye contact, rinse with water for at least 15 minutes; remove contaminated clothing. If inhaled, move to fresh air. If ingested, rinse mouth and seek medical attention. Provide SDS to responders.
• Waste: Collect solutions and contaminated disposables as organic hazardous waste. Follow institutional and local regulations.

Special note:

• Bioactive kinase inhibitors can have potent cellular effects. Handle with care, minimize exposure, and avoid environmental release.

Solvent Selection

ODM-203 is a bioactive small molecule typically used in solution for biochemical or cell-based assays. Item-specific solubility data are not provided; the following is general, literature-based guidance (non-spec):

• Primary stock solvent: DMSO is commonly used for kinase inhibitors due to strong solvating power and assay compatibility at low final percentages.
• Secondary solvents/co-solvents: DMF, NMP, ethanol, or methanol may dissolve similar scaffolds; verify compatibility with your assay and materials.
• Aqueous media: Following DMSO stock preparation, dilute into aqueous buffers (e.g., PBS, HBSS, assay buffer) with vigorous mixing; include carrier proteins (e.g., 0.1–0.5% BSA) or surfactants (e.g., 0.01–0.05% Tween-20) if nonspecific binding/precipitation is observed.
• pH effects: If the compound possesses ionizable groups (to be confirmed from structure/CoA), modest pH adjustments can improve solubility. Avoid extreme pH unless stability data support it.
• Adsorption: Hydrophobic inhibitors may adsorb to plastics; use low-bind polypropylene or glass vials and minimize surface area-to-volume ratios.

When to choose alternatives:

• If DMSO is incompatible with your system, evaluate PEG-400, cyclodextrin inclusion complexes, or liposomal vehicles, balancing solubility gains against assay interference.

Practical tips:

• Prepare fresh working solutions the day of use to minimize degradation.
• Filter clarify through 0.22 µm PTFE/nylon only if mass loss due to binding is acceptable; pre-rinse filters with solvent to condition.

Storage and Reconstitution

From Product Data (item-specific):

• Storage Conditions: Store at −20 °C.
• Shipping: Ice chest + ice pads.

Additional handling guidance (general best practices; not item-specific specifications):

• Container: Store dry in a tightly sealed, chemically compatible vial protected from light and moisture. Purge with inert gas if long-term storage is anticipated.
• Stock solutions: Prepare concentrated stocks in anhydrous DMSO. Aliquot into small volumes to avoid repeated freeze–thaw cycles. Record preparation date, solvent, and calculated concentration.
• Freeze–thaw: Minimize cycles. Thaw at room temperature, mix thoroughly, and inspect for precipitation or discoloration before use.
• Aqueous dilutions: Prepare immediately prior to experiments; prolonged storage in aqueous media is not recommended without stability data.
• Stability: Lot-specific stability/shelf-life and any desiccant requirements are not specified for this item; refer to CoA/Spec Sheet.

Research use only note:

• This product is intended exclusively for laboratory research. Do not use in humans or for diagnostic purposes.

Structure and Identity

ODM-203 is a bioactive small molecule included in Aladdin’s small-molecule library (Category: 全部 / 可售 / 小分子和化合物库). It is widely referenced in the kinase inhibitor literature as a research tool compound.

Item-specific identifiers (from Product Data):

• Product Name: ODM-203 (SKU: O414242)
• CAS: 1430723-35-5
• PubChem CID: 71554322
• InChIKey: 458484 (as provided)
• SMILES: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular Formula: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular Weight: Not specified for this item; refer to CoA/Spec Sheet.

Structural features (general literature description, non-item-specific):

• ODM-203 is described in the literature as a kinase inhibitor scaffold with multiple aromatic/heteroaromatic rings and heteroatoms that support hinge-binding in kinase ATP sites. Exact atom connectivity and stereochemistry should be confirmed from primary references or the CoA.
• Typical kinase-inhibitor motifs include: a heteroaromatic “hinge binder,” a substituted aryl region occupying the hydrophobic pocket, and solubilizing side chains. The precise functional groups for ODM-203 should be verified against an authenticated structural record (e.g., CoA/SDS or primary publication).

Synthetic Utility

ODM-203 is a finished bioactive small molecule and is not typically used as a reagent or intermediate in routine synthetic transformations.

If you are engaged in synthetic/medicinal chemistry related to ODM-203 (general, literature-based context):

• Scaffold modification: Access to analogs usually proceeds via modular coupling strategies (e.g., amide formation, SNAr on activated heteroaryl systems, Buchwald–Hartwig or Suzuki couplings) to vary hinge-binding heterocycles and peripheral aryl substituents.
• Late-stage diversification: Introduction of solubilizing motifs (tertiary amines, sulfonamides) or bioisosteres can tune potency/ADME. Protecting-group strategy and chemoselectivity are dictated by the specific scaffold; consult primary routes.
• Purification/analytics: Reverse-phase preparative HPLC is commonly employed due to polarity and aromaticity; confirm identity by LC–MS and NMR.

For practical use of ODM-203 as supplied, the above is informational only; it is not meant to imply reagent utility in synthetic chemistry. See Biological Roles and Pharmaceutical Uses for typical laboratory deployment.

Target Specificity

Item-specific biological target details (primary targets, isoform selectivity, Kd/IC50 values, species reactivity) are not provided in the Product Data for ODM-203.

• For experimental planning, consult primary literature or your internal databases for the latest target profile and off-target panel data associated with ODM-203.
• Include orthogonal assays to verify on-target activity in your specific model system.

Aladdin supplies this item for research use only; no diagnostic or therapeutic claims are made.