Olsalazine - Moligand™, 10 mM in DMSO , CAS No.15722-48-2

CAS: 15722-48-2 Cat. No.: O1499327 Molecular Weight: 302.24 EC Number: 605-089-5 PubChem CID: 22419

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Olsalazine is a potent inhibitor of macrophages chemotaxis to LTB4 with an IC 50 value of 0.39 mM, also reduces the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocyte (PMNL) and mononuclear cells (MNL). Olsalazine can be used for researching ulcerative colitis. Anti-inflammatory activity .

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Protected from light, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: C1=CC(=C(C=C1N=NC2=CC(=C(C=C2)O)C(=O)O)C(=O)O)O
• Alternate CAS: 15722-48-2,6054-98-4 (di-hydrochloride salt)
• PubChem CID: 22419
• MeSH Entry Terms: azodisal sodium;azodisalicylate;CJ-91B;Dipentum;disodium 5,5'-azodisalicylate;disodium azodisalicylate;olsalazine;olsalazine sodium;olsalazine, disodium salt;Rasal;sodium diazosalicylate
• Molecular Weight: 302.24

References

1. Yan Yan, Jinyao Sun, Xianting Xie, Pengchong Wang, Ying Sun, Yalin Dong, Jianfeng Xing.  (2018)  Colon-targeting mutual prodrugs of 5-aminosalicylic acid and butyrate for the treatment of ulcerative colitis.  RSC Advances,  8  (5): (2561-2574).  [PMID:35541446] [10.1039/C7RA13011B]