OSMI-4 - ≥97% , CAS No.2260791-14-6

CAS: 2260791-14-6 Cat. No.: O414263 Summenformel: C₂₇H₂₆ClN₃O₇S₂ Molekulargewicht: 604.09 PubChem CID: 137319721

QUALITÄT & REINHEIT ≥97%

Synonyms

ethyl (R)-N-(2-((7-chloro-2-oxo-1,2-dihydroquinoline)-6-sulfonamido)-2-(2-methoxyphenyl)acetyl)-N-(thiophen-2-ylmethyl)glycinate

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

Information

OSMI-4 OSMI-4 is an inhibitor of O-GlcNAc transferase (OGT) with EC50 of 3 μM in cells.

Targets

OGT (Cell-free assay) 3 μM(EC50)

In vitro

OSMI-4 reduces O-GlcNAc levels almost completely by 5 μM. A decrease in HCF-1 cleavage products and the appearance of uncleaved HCF-1 is observed in cells treated with OSMI-4. OSMI-4 is a kind of structure-based evolution of small molecule OGT inhibitors with low nanomolar binding affinities. OSMI-4 exhibits a ~3 μM EC50 in cells, making it especially attractive for probing OGT’s complex biology.

Cell Research(from reference)

Cell lines：HEK293T cells 

Concentrations：5 μM, 10 μM, 20 μM 

Incubation Time：2 h, 8 h, 16 h, 24 h 

Spezifikationen

Synonyme

ethyl (R)-N-(2-((7-chloro-2-oxo-1,2-dihydroquinoline)-6-sulfonamido)-2-(2-methoxyphenyl)acetyl)-N-(thiophen-2-ylmethyl)glycinate

Spezifikationen & Reinheit

≥97%

Biochemische und physiologische Mechanismen

OSMI-4 is an inhibitor of O-linked N-acetylglucosamine transferase (O-GlcNAc transferase, OGT) with EC50 of 3 μM in cells.

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Reinheit

≥97%

Produkteigenschaften

ALogP

3.175

HBD-Zahl

2

Rotationsfähige Bindung

12

Namen und Kennungen

Pubchem Sid

504773493

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504773493

Kanonisches Lächeln

CCOC(=O)CN(CC1=CC=CS1)C(=O)C(C2=CC=CC=C2OC)NS(=O)(=O)C3=C(C=C4C(=C3)C=CC(=O)N4)Cl

IUPAC Name

ethyl 2-[[(2R)-2-[(7-chloro-2-oxo-1H-quinolin-6-yl)sulfonylamino]-2-(2-methoxyphenyl)acetyl]-(thiophen-2-ylmethyl)amino]acetate

InChIKey

STPSLAZMEWZDAJ-AREMUKBSSA-N

INCHI

1S/C27H26ClN3O7S2/c1-3-38-25(33)16-31(15-18-7-6-12-39-18)27(34)26(19-8-4-5-9-22(19)37-2)30-40(35,36)23-13-17-10-11-24(32)29-21(17)14-20(23)28/h4-14,26,30H,3,15-16H2,1-2H3,(H,29,32)/t26-/m1/s1

PubChem CID

137319721

Molekulargewicht

604.09

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro DMSO: 100 mg/mL (165.53 mM); Water: Insoluble; Ethanol: Insoluble
• DMSO (mg/ml) Maximale Löslichkeit: 100
• DMSO (mM) Maximale Löslichkeit: 165.538247612111
• Wasser (mg/ml) Maximale Löslichkeit: ＜1