10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 18 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Paeonol (Peonol), a phenolic compound extracted from Chinese herbs Paeonia suffruticosa (moutan cortex) and Cynanchum paniculatum, inhibits MAO with an IC50 of about 50 μM.
In vitro
Paeonol (Peonol) is a phenolic compound extracted from Chinese herbs Paeonia suffruticosa (moutan cortex) and Cynanchum paniculatum. It has demonstrated significant MAOI activity. MAO-A and MAO-B inhibiting effects with IC50 values of 54.6 μM and 42.5 μM respectively. Paeonol shows antimutagenic, anti-inflammatory and analgesic effects. Paeonol also inhibits anaphylactic reaction by regulating histamine and TNF-α.
In vivo
LD50: Mice 608-899mg/kg (i.p.).
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
| Isomere SMILES | CC(=O)C1=C(C=C(C=C1)OC)O |
|---|---|
| WGK Deutschland | 3 |
| RTECS | RT1215000 |
| Molekulargewicht | 166.17 |
| Beilstein | 8267 |
| Reaxy-Rn | 1282794 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1282794&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Löslichkeit | Solubility (25°C) In vitro DMSO: 70 mg/mL (200.93 mM); Water: 70 mg/mL (200.93 mM); Ethanol: Insoluble; |
|---|---|
| Brechungsindex | 1.54 |
| Flammpunkt (°F) | 235.4 °F |
| Flammpunkt (°C) | 113 °C |
| Siedepunkt (°C) | 154°C/20mmHg |
| Schmelzpunkt (°C) | 47-50°C |
| 1. Chen Chen, Xiao Yang, Xian-hui Shao, Yue Zhou, Xiao-bin Zhang, Yun-ping Lu, Meng-zhen Xing, Qing-chang Xia, Yuan-xiang Liu, Yu-ning Ma, Ting-ting Zheng, Lin-lin Zhang, Yu-xia Ma, Ji-guo Yang. (2023) Thermal-grinding supramolecular network loaded with paeonol for treatment of skin eczema. CHEMICAL ENGINEERING SCIENCE, [PMID:] [10.1016/j.ces.2023.119096] |
| 2. Shuai Liu, Keming Zheng, Yilin Jiang, Susu Gai, Bohan Li, Dehai Li, Shuang Yang, Zhihua Lv. (2023) Biotransformation of Penindolone, an Influenza A Virus Inhibitor. MOLECULES, 28 (3): (1479). [PMID:36771146] [10.3390/molecules28031479] |
| 3. Siying Wang, Lanlan Xie, Qilei Yang, Yuting Geng, Hedi Kang, Xiuhua Zhao. (2022) Extraction and purification of paeonol from Moutan Cortex by a combined method of steam distillation and antisolvent recrystallization to reduce energy consumption and carbon dioxide emissions. CANADIAN JOURNAL OF CHEMICAL ENGINEERING, 101 (7): (3771-3785). [PMID:] [10.1002/cjce.24732] |
| 4. Yuling Wang, Zeyan Tang, Xueping Guo, Yuqi Zhao, Shujing Ren, Zhenhai Zhang, Huixia Lv. (2022) Hyaluronic acid-cyclodextrin encapsulating paeonol for treatment of atopic dermatitis. INTERNATIONAL JOURNAL OF PHARMACEUTICS, [PMID:35714817] [10.1016/j.ijpharm.2022.121916] |
| 5. Zhiping Che, Xiaolong Guo, Yuanhao Li, Song Zhang, Lina Zhu, Jiaxuan He, Di Sun, Yihao Guo, Yibo Liu, Ruxue Wei, Xiaobo Huang, Shengming Liu, Genqiang Chen, Yuee Tian. (2022) Synthesis of paeonol ester derivatives and their insecticidal, nematicidal, and anti-oomycete activities. PEST MANAGEMENT SCIENCE, 78 (8): (3442-3455). [PMID:35567371] [10.1002/ps.6985] |
| 6. Yipeng Gu, Kai Chen, Bingwen Xi, Jun Xie, Xuwen Bing. (2022) Paeonol increases the antioxidant and anti-inflammatory capacity of gibel carp (Carassius auratus gibelio) challenged with Aeromonas hydrophila. FISH & SHELLFISH IMMUNOLOGY, [PMID:35314333] [10.1016/j.fsi.2022.03.005] |
| 7. Yue-E Tian, Di Sun, Xiao-Xiao Han, Jin-Ming Yang, Song Zhang, Nan-Nan Feng, Li-Na Zhu, Zhong-Yuan Xu, Zhi-Ping Che, Sheng-Ming Liu, Xiao-Min Lin, Jia Jiang, Gen-Qiang Chen. (2021) Synthesis, anti-oomycete activity, and SAR studies of paeonol derivatives. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, [PMID:32009450] [10.1080/10286020.2020.1718116] |
| 8. Jingjing Yao, Yangxin Zhang, Qiming Hu, Decheng Zeng, Fang Hua, Wei Meng, Weiyun Wang, Guan-Hu Bao. (2017) Optimization of paeonol-loaded poly(butyl-2-cyanoacrylate) nanocapsules by central composite design with response surface methodology together with the antibacterial properties. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, [PMID:28189814] [10.1016/j.ejps.2017.01.028] |
| 9. Jingjing Yao, Decheng Zeng, Yangxin Zhang, Dongdong Sun, Endong Yang, Haiping Liu, Feng Guo, Weiyun Wang. (2016) Effect of solvents on forming poly(butyl-2-cyanoacrylate) encapsulated paeonol nanocapsules. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, [PMID:27846779] [10.1080/09205063.2016.1262161] |
| 10. Xie Xiaoyu, Pan Xiaoyan, Han Shengli, Wang Sicen. (2015) Development and characterization of magnetic molecularly imprinted polymers for the selective enrichment of endocrine disrupting chemicals in water and milk samples. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 407 (6): (1735-1744). [PMID:25577356] [10.1007/s00216-014-8425-0] |
| 11. Xin Li, Huimei Shi, Di Zhang, Bei Jing, Zhenni Chen, Yachun Zheng, Shiquan Chang, Li Gao, Guoping Zhao. (2023) Paeonol alleviates neuropathic pain by modulating microglial M1 and M2 polarization via the RhoA/p38MAPK signaling pathway. CNS Neuroscience & Therapeutics, [PMID:37032648] [10.1111/cns.14211] |
| 12. Songjun Liu, Xinran Cao, Tao Zhang, Chenyang Zhang, Jiao Qu, Yang Sun, Wen Lv, Fan Qu. (2022) Paeonol ameliorates endometrial hyperplasia in mice via inhibiting PI3K/AKT pathway-related ferroptosis. PHYTOMEDICINE, [PMID:36610113] [10.1016/j.phymed.2022.154593] |
| 13. Chunqing Niu, Xiang Li, Yiyu Wang, Xinyu Liu, Jian Shi, Xinyu Wang. (2019) Design and performance of a poly(vinyl alcohol)/silk fibroin enzymatically crosslinked semi-interpenetrating hydrogel for a potential hydrophobic drug delivery. RSC Advances, 9 (70): (41074-41082). [PMID:35540084] [10.1039/C9RA09344C] |
| 14. Ping Mao, Xiao Wei, Mo Liqian, Xiao Xiaoyan, Song Shaolian, Tang Waijiao, Yang Xixiao. (2014) Paeonol Attenuates Advanced Oxidation Protein Product-Induced Oxidative Stress Injury in THP-1 Macrophages. PHARMACOLOGY, [PMID:25170865] [10.1159/000363577] |
| 15. Xin Li, Zifeng Zhuang, Yuting Hao, Shaozi Lin, Junyan Gu, Shiquan Chang, Lin Lan, Guoping Zhao, Di Zhang. (2025) Paeonol Relieves Chronic Neuropathic Pain by Reducing Communication Between Schwann Cells and Macrophages in the Dorsal Root Ganglia After Injury. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 26 (9): (3964). [PMID:40362205] [10.3390/ijms26093964] |
| 16. Miao Li, Na Gao, Lei Xu, Peng Ge, Nan Jiang, Yuhong Shang. (2025) Integrative RNA-seq and LASSO-COX analysis reveal Paeonol’s key target gene in proliferation suppression and apoptosis-induced in cervical cancer. Frontiers in Pharmacology, [PMID:41126956] [10.3389/fphar.2025.1646473] |
| 17. Xu Chen, Jianxing Liu, Yongrui Liang, Zihan Gong. (2026) Paeonol inhibits the progression of endometrial cancer by affecting TRIM26-mediated LDHA ubiquitination modification. TISSUE & CELL, [PMID:41691946] [10.1016/j.tice.2026.103359] |
| 18. Liu-Jie Qi, Zhao-Qi Zhang, Zhong-Na Zhang, Jing-An Li, Shao-Kang Guan. (2026) Theoretical calculation-experimental collaborative design of integrated coating for degradation regulation and diagnosis-treatment of magnesium alloy for cerebrovascular stents. Journal of Advanced Research, [PMID:41713732] [10.1016/j.jare.2026.02.028] |
