PD128907 HCl - ≥98% , CAS No.112960-16-4

CAS: 112960-16-4 Cat. No.: P129442 Summenformel: C₁₄H₁₉NO₃·HCl Molekulargewicht: 285.77

GRADE & PURITY ≥98%

Synonyms

trans-(+/-)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4,9-dioxa-1-aza-phenanthren-6-ol hydrochloride | (+/-)-PD 128,907 hydrochloride, solid, >=98% (HPLC) | 2,3-Dimethoxy-5-methyl-6-(farnesylfarnesyl)-1,4-benzoquinone | EU-0100988 | PD128907Hydrochloride | R(

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.

Specifications

Synonyme

trans-(+/-)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4,9-dioxa-1-aza-phenanthren-6-ol hydrochloride | (+/-)-PD 128,907 hydrochloride, solid, >=98% (HPLC) | 2,3-Dimethoxy-5-methyl-6-(farnesylfarnesyl)-1,4-benzoquinone | EU-0100988 | PD128907Hydrochloride | R(

Spezifikationen & Reinheit

≥98%

Biochemische und physiologische Mechanismen

Selective D3 dopamine receptor agonist.Potent, selective D 3 receptor agonist (K i = 2.3 nM). Inhibits dopamine release. Reduces GABAAR current in acutely dissociated NAc neurons. Shows locomotor-inhibitory effects in vivo.

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Hinweis

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Reinheit

≥98%

Namen und Kennungen

• Pubchem Sid: 528766556
• Kanonisches Lächeln: CCCN1CCOC2C1COC3=C2C=C(C=C3)O.Cl
• IUPAC Name: (4aR,10bR)-4-propyl-3,4a,5,10b-tetrahydro-2H-chromeno[4,3-b][1,4]oxazin-9-ol;hydrochloride
• InChIKey: DCFXOTRONMKUJB-QMDUSEKHSA-N
• INCHI: 1S/C14H19NO3.ClH/c1-2-5-15-6-7-17-14-11-8-10(16)3-4-13(11)18-9-12(14)15;/h3-4,8,12,14,16H,2,5-7,9H2,1H3;1H/t12-,14-;/m1./s1
• Isomere SMILES: CCCN1CCO[C@H]2[C@H]1COC3=C2C=C(C=C3)O.Cl
• WGK Deutschland: 3
• Molekulargewicht: 285.77
• Reaxy-Rn: 37356230
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=37356230&ln=

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HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)

Discover Target: HTR2A

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OPRM1 Tclin Mu opioid receptor (19785 Activities)

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DRD3 Tclin Dopamine D3 receptor (14368 Activities)

Discover Target: DRD3

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

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ERG Tbio Transcriptional regulator ERG (5589 Activities)

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LMNA Tbio Prelamin-A/C (36751 Activities)

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BLM Tchem Bloom syndrome protein (4248 Activities)

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CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

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MPHOSPH8 Tbio M-phase phosphoprotein 8 (656 Activities)

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GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)

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Plasmodium falciparum (966862 Activities)

Explore this target

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Npsr1 Neuropeptide S receptor (260 Activities)

Discover Target: Npsr1

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

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nfo Endonuclease 4 (425 Activities)

Discover Target: nfo

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Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO 12 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
• Molekulargewicht: 285.760 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 285.113 Da
• Monoisotopic Mass: 285.113 Da
• Topological Polar Surface Area: 41.900 Ų
• Heavy Atom Count: 19
• Formal Charge: 0
• Complexity: 286.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3