Name: PF 05175157 - ≥98%(HPLC) , Acetyl-CoA carboxylase inhibitor, CAS No.1301214-47-0, Acetyl-CoA carboxylase inhibitor
SKU: P288592
Availability: InStock

PF 05175157 - ≥98%(HPLC) , Acetyl-CoA carboxylase inhibitor, CAS No.1301214-47-0, Acetyl-CoA carboxylase inhibitor

CAS: 1301214-47-0 Cat. No.: P288592 Summenformel: C₂₃H₂₇N₅O₂ Molekulargewicht: 405.49 PubChem CID: 52934180

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PF 05175157 - ≥98%(HPLC) CAS No(1301214-47-0) by Aladdin Scientific

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GRADE & PURITY ≥98%(HPLC)

Synonyms

Z2327390391 | NCGC00421916-02 | s6672 | BCC21447 | (3-Methyl-5-isopropylphenyl)-N-methylcarbamat [Deutsch] | 1'-(2-Methyl-3H-benzimidazol-5-carbonyl)-1-propan-2-ylspiro[4,6-dihydroindazol-5,4'-piperidin]-7-on | 1-Isopropyl-1'-(2-methyl-1H-benzo[d]imida

Storage

Lagerung bei -20°C

Shipped In

Eistruhe + Eispads

Übersicht Specifications Produkteigenschaften Namen und Kennungen Documentation Advanced Data Taxonomic Classification 3D-Struktur Zugehörige Ziele (menschlich) Zugehörige Ziele (nicht menschlich) Wirkungsmechanismen Zertifikate (CoA, COO, BSE/TSE und Analyse-Diagramm) Chemische und physikalische Eigenschaften FAQs und Artikel Lösungsrechner Bewertungen

🧪

Why this grade

≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Lagerung bei -20°C Ships Eistruhe + Eispads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Übersicht

Produkt Anwendung:

PF-05175157 ist ein Breitspektrum-Inhibitor der Acetyl-CoA-Carboxylase (ACC) mit IC50-Werten von 27,0, 33,0, 23,5 und 50,4 nM für ACC1 (Mensch), ACC2 (Mensch), ACC1 (Ratte) bzw. ACC2 (Ratte).

Produkt-Beschreibung:

PF-05175157 wurde als Acetyl-Coenzym-A-Carboxylase (ACC)-Inhibitor verwendet, um seine Auswirkungen auf die Infektion von Flaviviren zu untersuchen.

Specifications

Synonyme

Spezifikationen & Reinheit

≥98%(HPLC)

Biochemische und physiologische Mechanismen

Inhibitor der Acetyl-CoA-Carboxylase (ACC) 2 und 1 (IC50-Werte sind 45 bzw. 98 nM). Verringert den Malonyl-CoA-Spiegel in der Leber und in der Skelettmuskulatur von Ratten. Hemmt auch die hepatische Novolipogenese und verringert das Verhältnis der Atmungs

Storage

Lagerung bei -20°C

Verschickt in

Eistruhe + Eispads

Aktionsart

INHIBITOR

Mechanismus der Wirkung

Acetyl-CoA carboxylase inhibitor

Reinheit

≥98%(HPLC)

Produkteigenschaften

ALogP	2.7

Namen und Kennungen

Pubchem Sid	488201524
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488201524
Kanonisches Lächeln	CC1=NC2=C(N1)C=C(C=C2)C(=O)N3CCC4(CC3)CC5=C(C(=O)C4)N(N=C5)C(C)C
IUPAC Name	1'-(2-methyl-3H-benzimidazole-5-carbonyl)-1-propan-2-ylspiro[4,6-dihydroindazole-5,4'-piperidine]-7-one
InChIKey	BDXXSFOJPYSYOC-UHFFFAOYSA-N
INCHI	1S/C23H27N5O2/c1-14(2)28-21-17(13-24-28)11-23(12-20(21)29)6-8-27(9-7-23)22(30)16-4-5-18-19(10-16)26-15(3)25-18/h4-5,10,13-14H,6-9,11-12H2,1-3H3,(H,25,26)
Isomere SMILES	CC1=NC2=C(N1)C=C(C=C2)C(=O)N3CCC4(CC3)CC5=C(C(=O)C4)N(N=C5)C(C)C
PubChem CID	52934180
Molekulargewicht	405.49

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Klasse Piperidines
    - Subclass N-acylpiperidines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Klasse	Piperidines
Subclass	N-acylpiperidines
Intermediate Tree Nodes	Not available
Direct Parent	N-benzoylpiperidines
Alternative Parents	Benzimidazoles Aryl alkyl ketones Benzenoids Tertiary carboxylic acid amides Pyrazoles Imidazoles Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	N-benzoylpiperidine - Benzimidazole - Aryl ketone - Aryl alkyl ketone - Benzenoid - Azole - Imidazole - Pyrazole - Tertiary carboxylic acid amide - Heteroaromatic compound - Carboxamide group - Ketone - Azacycle - Carboxylic acid derivative - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Aromatic heteropolycyclic compound
Beschreibung	This compound belongs to the class of organic compounds known as n-benzoylpiperidines. These are heterocyclic Compounds containing a piperidine ring conjugated to a benzyl group through one nitrogen ring atom.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D-Struktur

Zugehörige Ziele (menschlich)

ACACB Tchem Acetyl-CoA carboxylase 2 (2 Activities)

Discover Target: ACACB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACACA Tchem Acetyl-CoA carboxylase 1 (2 Activities)

Discover Target: ACACA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACACA Tchem Acetyl-CoA carboxylase 1 (794 Activities)

Discover Target: ACACA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACACB Tchem Acetyl-CoA carboxylase 2 (3474 Activities)

Discover Target: ACACB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A5 Tclin Cytochrome P450 3A5 (525 Activities)

Discover Target: CYP3A5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Homo sapiens (32628 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Zugehörige Ziele (nicht menschlich)

Canis familiaris (36305 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rhesus monkey (3147 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Liver microsome (341 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Zertifikate (CoA, COO, BSE/TSE und Analyse-Diagramm)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Datum	Artikel
D2312516	Certificate of Analysis	Jan 20, 2026	P288592
D2312517	Certificate of Analysis	Jan 20, 2026	P288592
D2312518	Certificate of Analysis	Jan 20, 2026	P288592
D2312519	Certificate of Analysis	Jan 20, 2026	P288592
D2312520	Certificate of Analysis	Jan 20, 2026	P288592
D2312522	Certificate of Analysis	Jan 20, 2026	P288592
D2312523	Certificate of Analysis	Jan 20, 2026	P288592
D2312526	Certificate of Analysis	Jan 20, 2026	P288592
D2312528	Certificate of Analysis	Jan 20, 2026	P288592
D2312525	Certificate of Analysis	Mar 03, 2023	P288592

Chemische und physikalische Eigenschaften

Löslichkeit	Solvent:DMSO, Max Conc. mg/mL: 20.27, Max Conc. mM: 50; Solvent:ethanol, Max Conc. mg/mL: 8.11, Max Conc. mM: 20
Empfindlichkeit	light sensitive
Molekulargewicht	405.500 g/mol
XLogP3	2.700
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	405.216 Da
Monoisotopic Mass	405.216 Da
Topological Polar Surface Area	83.900 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	689.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

FAQs und Artikel

Lipid Regulatory Mechanisms in Inflammation and Immune Responses

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

Lipid metabolism Cholesterol arachidonic acid Inflammatory Response Immune Regulation Prostaglandins Leukotrienes Sphingolipids Lipid Droplets Inflammation Resolution

Molecular Mechanisms of Crosstalk Between Glucose and Lipid Metabolism in the Initiation and Progression of Metabolic Diseases

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

O-GlcNAc

Why Do Cancer Cells Synthesize Their Own Fatty Acids? From the De Novo Fatty Acid Synthesis Pathway to Experimental Assessment

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

Cancer Cells Synthetic fatty acids

Lösungsrechner

Molarity Calculator

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Dilution Calculator

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Reconstitution Calculator

Bewertungen

Bulk & Custom Packaging Need larger quantities or custom specifications? Contact our team for a tailored quote.

PF 05175157 - ≥98%(HPLC) , Acetyl-CoA carboxylase inhibitor, CAS No.1301214-47-0, Acetyl-CoA carboxylase inhibitor

Why this grade

Storage & shipping

Quality documents

Literature proof

Übersicht

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Kundenbewertungen

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