PF-05198007 - ≥99% , CAS No.1235406-19-5

CAS: 1235406-19-5 Cat. No.: P649360 Summenformel: C₁₉H₁₂ClF₄N₅O₃S₂ Molekulargewicht: 533.91

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

PF-05198007 is a potent, orally active and selective arylsulfonamide Na v 1.7 inhibitor. PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771

In Vitro

PF-05198007 (30 nM) blocks on average 83.0 ± 2.7% of the total TTX-S current indicating that the major TTX-S conductance is carried through Na v 1.7 channels in small-diameter mouse DRG neurons (n = 35). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PF-05198007 (1 or 10 mg/kg, orally) reduces the capsaicin flare response in WT, but not Na v 1.7Na v 1.8Cre mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Adult Male C57Bl/6J Wild type (WT) and Na v 1.7Na v 1.8Cre mice . Dosage: 1 or 10 mg/kg. Administration: Orally once. Result: Reduced the flare response to capsaicin for the duration of the observation period (55 mins; Vehicle; 4930 ± 751 versus 1 and 10 mg/kg 1967 ± 472 and 2265 ± 382, respectively (n = 7), AUC, p < 0.05).

Form:Solid

IC50& Target:Nav1.7

Specifications

Spezifikationen & Reinheit

≥99%

Biochemische und physiologische Mechanismen

PF-05198007 is a potent, orally active and selective arylsulfonamide Na v 1.7 inhibitor. PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771.

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Reinheit

≥99%

Namen und Kennungen

• Molekulargewicht: 533.91

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO : 150 mg/mL (280.95 mM; Need ultrasonic)

Häufig gestellte Fragen

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1235406-19-5, the molecular formula is C19H12ClF4N5O3S2, and the molecular weight is 533.91 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.