Phenamil Hydrate - Moligand™, ≥95% , Channel blocker of TRPP2, CAS No.2038-35-9, Channel blocker of TRPP2

CAS: 2038-35-9 Cat. No.: P335535 Summenformel: C₁₂H₁₂ClN₇O.xH₂O Molekulargewicht: 305.72 (anhy)

GRADE & PURITY Moligand™, ≥95%

Synonyms

Bio1_001134 | NCGC00162311-03 | Bio1_000645 | HMS3402H15 | MLS002172443 | Bio2_000153 | CID 5353878 | NCGC00162311-06 | SMR003929926 | Bio1_000156 | 3,5-diamino-N-[(1E)-amino(phenylamino)methylidene]-6-chloropyrazine-2-carboxamide | CBiol_001870 | BDBM115

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Übersicht

Phenamil is an amiloride analog. Irreversibly blocks ENaC (amiloride-sensitive Na|+|channels).Phenamil is a compound that promotes bone repair and regulates stem cell differentiation. It can activate the bone morphogenetic protein signaling pathway to promote bone repair, but it also induces adipogenesis. A specific 3D scaffold strategy can improve its induced osteogenic differentiation and reduce adipogenesis.

Specifications

Synonyme

Bio1_001134 | NCGC00162311-03 | Bio1_000645 | HMS3402H15 | MLS002172443 | Bio2_000153 | CID 5353878 | NCGC00162311-06 | SMR003929926 | Bio1_000156 | 3,5-diamino-N-[(1E)-amino(phenylamino)methylidene]-6-chloropyrazine-2-carboxamide | CBiol_001870 | BDBM115

Spezifikationen & Reinheit

Moligand™, ≥95%

Storage

Store at -20°C,Argon charged

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

CHANNEL BLOCKER

Mechanismus der Wirkung

Channel blocker of TRPP2

Reinheit

≥95%

Namen und Kennungen

• Pubchem Sid: 528766754
• Kanonisches Lächeln: C1=CC=C(C=C1)N=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N
• IUPAC Name: 3,5-diamino-6-chloro-N-(N'-phenylcarbamimidoyl)pyrazine-2-carboxamide
• InChIKey: NIOHELZQFBGCEO-UHFFFAOYSA-N
• INCHI: 1S/C12H12ClN7O/c13-8-10(15)19-9(14)7(18-8)11(21)20-12(16)17-6-4-2-1-3-5-6/h1-5H,(H4,14,15,19)(H3,16,17,20,21)
• Isomere SMILES: C1=CC=C(C=C1)N=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N
• WGK Deutschland: 3
• Alternative CAS-Nummer: 1161-94-0
• Molekulargewicht: 305.72 (anhy)

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Klasse Diazines
      • Subclass Pyrazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Klasse: Diazines
• Subclass: Pyrazines
• Intermediate Tree Nodes: Not available
• Direct Parent: Aminopyrazines
• Alternative Parents: Imidolactams Benzene and substituted derivatives Aryl chlorides Heteroaromatic compounds Propargyl-type 1,3-dipolar organic compounds Azacyclic compounds Primary amines Organopnictogen compounds Organooxygen compounds Organochlorides Imines Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Aminopyrazine - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Benzenoid - Imidolactam - Heteroaromatic compound - Azacycle - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Primary amine - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Imine - Hydrocarbon derivative - Organopnictogen compound - Organic oxygen compound - Amine - Organic nitrogen compound - Aromatic heteromonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as aminopyrazines. These are organic compounds containing an amino group attached to a pyrazine ring.
• External Descriptors: pyrazines - carboxamide

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

SCNN1A Tclin Amiloride-sensitive sodium channel subunit alpha (1 Activities)

Discover Target: SCNN1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PKD2L1 Tchem Polycystic kidney disease 2-like 1 protein (1 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD1 Tclin Dopamine D1 receptor (9720 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SCNN1A Tclin Amiloride-sensitive sodium channel alpha-subunit (48 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

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SH-SY5Y (11521 Activities)

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HEK293 (82097 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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SMN1 Tchem Survival motor neuron protein (34246 Activities)

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NPC1 Tchem Niemann-Pick C1 protein (18985 Activities)

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RAB9A Tbio Ras-related protein Rab-9A (22488 Activities)

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ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

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HSPA5 Tchem 78 kDa glucose-regulated protein (3319 Activities)

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Saccharomyces cerevisiae (19171 Activities)

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lef Anthrax lethal factor (7585 Activities)

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pfk 6-phospho-1-fructokinase (7870 Activities)

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

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Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Soluble in water (partly), DMSO (15 mg/ml), and 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (2.5 mg/ml). Insoluble in 0.1 M HCl, and dilute aquueous acid .
• Brechungsindex: n20D1.76 (Predicted)
• Siedepunkt (°C): 621.7° C at 760 mmHg (Predicted) (tautomer)
• Schmelzpunkt (°C): 258-260° C
• Molekulargewicht: 305.720 g/mol
• XLogP3: 1.800
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 305.079 Da
• Monoisotopic Mass: 305.079 Da
• Topological Polar Surface Area: 145.000 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 399.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1