Information
Phenoxodiol (Haginin E, Idronoxil, Dehydroequol, NV 06, PXD) is an isoflavone analog with antineoplastic activity that activates thecaspasesystem, inhibitsXIAP (X-linked inhibitor of apoptosis), and disruptsFLICE inhibitory protein (FLIP)expression, resulting in tumor cellapoptosis. Phenoxodiol also inhibitsDNA topoisomerase II.
Targets
Caspase ; XIAP ; FLIP ; Topo II
In vitro
Primary ovarian cancer cells, isolated from ascitic fluids of ovarian cancer patients, resistant to conventional chemotherapy, undergo apoptosis following phenoxodiol treatment. This effect is dependent upon the activation of the caspase system, inhibiting XIAP, an inhibitor of apoptosis, and disrupting FLICE inhibitory protein (FLIP) expression through the Akt signal transduction pathway. Phenoxodiol is an efficient inducer of cell death in ovarian cancer cells and sensitizes the cancer cells to Fas-mediated apoptosis.
In vivo
In an in vivo colon cancer model, Balb/C mice administered low-dose Phenoxodiol (PXD), exhibits significantly reduced tumour growth rates and prolonged survival (in 40% of the animals).
Cell Research(from reference)
Cell lines：primary ovarian cancer cells
Concentrations：0.1 μg/ml, 1 μg/ml, 10 μg/ml
Incubation Time：24 h
