Phloretin - Moligand™, ≥98% , Inhibitor of AQP9;Channel blocker of ClC-3;Agonist of TAS2R14;Agonist of TAS2R39;Inhibitor of major facilitator superfamily domain containing 4B;Inhibitor of Sodium-dependent vitamin C transporter 1, CAS No.60-82-2, Inhibitor of AQP9;Channel blocker of ClC-3;Agonist of TAS2R14;Agonist of TAS2R39;Inhibitor of major facilitator superfamily domain containing 4B;Inhibitor of Sodium-dependent vitamin C transporter 1

CAS: 60-82-2 Cat. No.: P127748 Molecular Weight: 274.27 Beilstein Registry Number: 1887240 EC Number: 200-488-7
AVAILABLE TO ORDER
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
KBio1_001373 | LMPK12120525 | P1966 | PHLORETIN [MI] | Tox21_501012 | Asebogenol | Lopac-P-7912 | 2',4',6'-Trihydroxy-3-(4-Hydroxyphenyl)propiophenone | 2',4',6'-Trihydroxy-3-(4-hydroxyphenyl)-propiophenone | beta-(p-Hydroxyphenyl)-2,4,6-trihydroxypropiop
Storage
Store at 2-8°C,Argon charged
Shipped In
Wet ice
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
250mg
P127748-250mg
2
$9.90
1g
P127748-1g
2
$10.90
5g
P127748-5g
3
$14.90
25g
P127748-25g
1
$49.90
100g
P127748-100g
3
$119.90
Enter a quantity for the sizes you want to add.
🧪

Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at 2-8°C,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 45 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Phloretin is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.
A calcium channel protein inhibitor.

Specifications

Synonyms
KBio1_001373 | LMPK12120525 | P1966 | PHLORETIN [MI] | Tox21_501012 | Asebogenol | Lopac-P-7912 | 2', 4', 6'-Trihydroxy-3-(4-Hydroxyphenyl)propiophenone | 2', 4', 6'-Trihydroxy-3-(4-hydroxyphenyl)-propiophenone | beta-(p-Hydroxyphenyl)-2, 4, 6-trihydroxypropiop
Specifications & Purity
Moligand™, ≥98%
Biochemical and Physiological Mechanisms
Phloretin is an inhibitor of calcium channel protein, MCT1, MCT2, and PKC. It is the major polyphenol found in apple.Dihydrochalcones flavonoid. GLUT inhibitor. Active phlorizin metabolite. Blocks L-type Ca 2+ channels. Activates Ca 2+ -activated K + chan
Storage
Store at 2-8°C, Argon charged
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
AGONIST, CHANNEL BLOCKER, INHIBITOR
Mechanism of action
Inhibitor of AQP9;Channel blocker of ClC-3;Agonist of TAS2R14;Agonist of TAS2R39;Inhibitor of major facilitator superfamily domain containing 4B;Inhibitor of Sodium-dependent vitamin C transporter 1
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Purity
≥98%
Names and Identifiers
Pubchem Sid504750814
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504750814
Canonical SmilesC1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O)O)O)O
IUPAC Name3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
InChIKeyVGEREEWJJVICBM-UHFFFAOYSA-N
INCHI1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2
Isomeric SMILES C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O)O)O)O
WGK Germany 3
Molecular Weight 274.27
Beilstein 1887240
Reaxy-Rn 1887240
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1887240&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassPhenylpropanoids and polyketides
ClassLinear 1,3-diarylpropanoids
SubclassChalcones and dihydrochalcones
Intermediate Tree Nodes Not available
Direct Parent2'-Hydroxy-dihydrochalcones
Alternative Parents Cinnamylphenols  Alkyl-phenylketones  Butyrophenones  Acylphloroglucinols and derivatives  Benzoyl derivatives  Aryl alkyl ketones  1-hydroxy-4-unsubstituted benzenoids  1-hydroxy-2-unsubstituted benzenoids  Vinylogous acids  Polyols  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAromatic homomonocyclic compounds
Substituents 2'-hydroxy-dihydrochalcone - Cinnamylphenol - Alkyl-phenylketone - Acylphloroglucinol derivative - Butyrophenone - Benzenetriol - Phloroglucinol derivative - Phenylketone - Aryl alkyl ketone - Aryl ketone - Benzoyl - Phenol - 1-hydroxy-2-unsubstituted benzenoid - 1-hydroxy-4-unsubstituted benzenoid - Benzenoid - Monocyclic benzene moiety - Vinylogous acid - Ketone - Polyol - Organic oxide - Organic oxygen compound - Organooxygen compound - Hydrocarbon derivative - Aromatic homomonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as 2'-hydroxy-dihydrochalcones. These are organic compounds containing dihydrochalcone skeleton that carries a hydroxyl group at the 2'-position.
External Descriptors a small molecule
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
SLC23A1 Tchem Solute carrier family 23 member 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TAS2R39 Tchem Taste receptor type 2 member 39 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TAS2R14 Tchem Taste receptor type 2 member 14 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
AQP9 Tbio Aquaporin-9 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CLCN3 Tchem H(+)/Cl(-) exchange transporter 3 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MFSD4B Tdark Sodium-dependent glucose transporter 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TOP2A Tclin DNA topoisomerase II alpha (6317 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TYR Tclin Tyrosinase (717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLB Tchem DNA polymerase beta (23632 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ARSA Tbio Cerebroside-sulfatase (655 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC2A1 Tchem Glucose transporter (14755 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNMA1 Tclin Calcium-activated potassium channel subunit alpha-1 (435 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TP53 Tchem Cellular tumor antigen p53 (48468 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATM Tchem Serine-protein kinase ATM (4198 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HaCaT (4069 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FEN1 Tchem Flap endonuclease 1 (12055 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC16A1 Tchem Monocarboxylate transporter 1 (146 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACP1 Tchem Low molecular weight phosphotyrosine protein phosphatase (1161 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLK Tbio DNA polymerase kappa (8653 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCG2 Tchem ATP-binding cassette sub-family G member 2 (4927 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC28A3 Tchem Solute carrier family 28 member 3 (29 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RECQL Tbio ATP-dependent DNA helicase Q1 (5575 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KMT2A Tchem Histone-lysine N-methyltransferase MLL (17327 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MPHOSPH8 Tbio M-phase phosphoprotein 8 (656 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
blaZ Beta-lactamase (285 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Alpha-chymotrypsin (819 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ttr Transthyretin (14 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abcc1 Multidrug resistance-associated protein 1 (42 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abcb1b P-glycoprotein 1 (174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slc5a1 Sodium/glucose cotransporter 1 (11 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slc5a2 Sodium/glucose cotransporter 2 (17 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Listeria monocytogenes (2626 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Saccharomyces cerevisiae (19171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Enterococcus faecalis (29875 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus cereus (7522 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
3T3-L1 (3664 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Vero (26788 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
lef Anthrax lethal factor (7585 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
fabH 3-oxoacyl-[acyl-carrier-protein] synthase 3 (47 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Luciferin 4-monooxygenase (66902 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
norA Quinolone resistance protein norA (2171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Protease (18 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NS1 Nonstructural protein 1 (33327 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PNLIP Pancreatic triacylglycerol lipase (476 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

26 results found

Lot NumberCertificate TypeDateItem
J2210680Certificate of AnalysisMay 20, 2026 P127748
F2609679Certificate of AnalysisMay 15, 2026 P127748
F2609651Certificate of AnalysisMay 15, 2026 P127748
F2609647Certificate of AnalysisMay 15, 2026 P127748
F2609646Certificate of AnalysisMay 15, 2026 P127748
F2609645Certificate of AnalysisMay 15, 2026 P127748
J2210681Certificate of AnalysisApr 03, 2026 P127748
J2210662Certificate of AnalysisApr 03, 2026 P127748
J2210661Certificate of AnalysisApr 03, 2026 P127748
D2608048Certificate of AnalysisJun 12, 2025 P127748
H2505470Certificate of AnalysisJun 12, 2025 P127748
H2505469Certificate of AnalysisJun 12, 2025 P127748
H2505468Certificate of AnalysisJun 12, 2025 P127748
H2505467Certificate of AnalysisJun 12, 2025 P127748
H2505466Certificate of AnalysisJun 12, 2025 P127748
E2529149Certificate of AnalysisJun 05, 2025 P127748
B2514035Certificate of AnalysisFeb 21, 2025 P127748
H2405013Certificate of AnalysisAug 13, 2024 P127748
F2503518Certificate of AnalysisJul 12, 2024 P127748
E2224117Certificate of AnalysisMar 20, 2024 P127748
H2124478Certificate of AnalysisJun 07, 2023 P127748
H2124477Certificate of AnalysisJun 07, 2023 P127748
C2419221Certificate of AnalysisJul 23, 2022 P127748
A2403030Certificate of AnalysisJul 23, 2022 P127748
E2224255Certificate of AnalysisMar 21, 2022 P127748
E2224260Certificate of AnalysisMar 21, 2022 P127748

Show more ⌵

Chemical and Physical Properties
SolubilitySoluble in ethanol, methanol, acetone, hot glacial acetic acid, alkalies, benzene (sparingly soluble), chloroform (sparingly soluble), and DMSO. Insoluble in water, and ether.
Sensitivitylight and air and heat sensitive
Melt Point(°C)262°C
Molecular Weight274.270 g/mol
XLogP32.600
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass274.084 Da
Monoisotopic Mass274.084 Da
Topological Polar Surface Area98.000 Ų
Heavy Atom Count20
Formal Charge0
Complexity312.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
References
1. Meng Zhang, Xue Zhuang, Siqi Li, Yansong Wang, Xiangyu Zhang, Jinlian Li, Dongmei Wu.  (2023)  Designed Fabrication of Phloretin-Loaded Propylene Glycol Binary Ethosomes: Stability, Skin Permeability and Antioxidant Activity.  MOLECULES,  29  (1): (66).  [PMID:38202649] [10.3390/molecules29010066]
2. Yu Hu, Hui Guo, Shuai Cheng, Junpeng Sun, Jiaqun Du, Xiaobang Liu, Ying Xiong, Liqing Chen, Chang Liu, Chao Wu, He Tian.  (2023)  Functionalized Cerium Dioxide Nanoparticles with Antioxidative Neuroprotection for Alzheimer’s Disease.  International Journal of Nanomedicine,      [PMID:38026525] [10.2147/IJN.S434873]
3. Hong Hu, Liang Chen, Ying Huang, Kunping Wang, Xi Bai, Hongbin Pan.  (2023)  CUT&tag-seq analysis of heat stress response in broiler liver provides novel insights into the improved thermotolerance by dietary phloretin.  ANNALS OF AGRICULTURAL SCIENCE,      [PMID:] [10.1016/j.aoas.2023.02.002]
4. Wang Jie, Jia Jingyu, Sun Jiaju, Pang Xinyue, Li Bairu, Yuan Jiangfeng, Chen Enyan, Li Xin.  (2023)  Trypsin preservation: CsUGT91C1 regulates Trilobatin Biosynthesis in Cucumis sativus during Storage.  PLANT GROWTH REGULATION,  100  (3): (633-646).  [PMID:] [10.1007/s10725-023-00962-w]
5. Yang Liu, Jiali Lin, Tiantian Cheng, Yangjie Liu, Fuliang Han.  (2022)  Methylation, Hydroxylation, Glycosylation and Acylation Affect the Transport of Wine Anthocyanins in Caco-2 Cells.  Foods,  11  (23): (3793).  [PMID:36496602] [10.3390/foods11233793]
6. Mile Li, Mengyi Wang, Shuhui Hu, Jing Sun, Mingqiang Zhu, Yongsheng Ni, Jianlong Wang.  (2022)  Advanced Coatings with Antioxidant and Antibacterial Activity for Kumquat Preservation.  Foods,  11  (15): (2363).  [PMID:35954129] [10.3390/foods11152363]
7. Yingqiao Li, Zhiru Zou, Jinyu An, Qian Wu, Le Tong, Xifan Mei, He Tian, Chao Wu.  (2022)  Chitosan-modified hollow manganese dioxide nanoparticles loaded with resveratrol for the treatment of spinal cord injury.  DRUG DELIVERY,      [PMID:35903814] [10.1080/10717544.2022.2104957]
8. Zhang Guorong, Wang Qin, Tao Wanyin, Jiang Wei, Elinav Eran, Wang Yucai, Zhu Shu.  (2022)  Glucosylated nanoparticles for the oral delivery of antibiotics to the proximal small intestine protect mice from gut dysbiosis.  Nature Biomedical Engineering,  (7): (867-881).  [PMID:35798834] [10.1038/s41551-022-00903-4]
9. Fang Li, Yachao Xi, Jianming Jiang, Hao Peng, Bing Li, Jianbo He, Jiangnan Shu, Hua Cui.  (2022)  O-Fluorobenzoic Acid-Mediated Construction of Porous Graphitic Carbon Nitride with Nitrogen Defects for Multicolor Electrochemiluminescence Imaging Sensing.  ANALYTICAL CHEMISTRY,      [PMID:35738019] [10.1021/acs.analchem.2c00702]
10. Zhiru Zou, Shan Wen, Yingqiao Li, Jinyu An, Qian Wu, Le Tong, Xifan Mei, He Tian, Chao Wu.  (2022)  Novel lactoferrin-functionalized manganese-doped silica hollow mesoporous nanoparticles loaded with resveratrol for the treatment of ischemic stroke.  Materials Today Advances,      [PMID:] [10.1016/j.mtadv.2022.100262]
11. Zhang Pengpeng, Zhang Miaomiao, Dong Kaiyu, Zhang Yicong, Yang Shuang, Wang Yuanhong, Jiang Tingfu, Yu Mingming, Lv Zhihua.  (2022)  Evaluation of Chito-Oligosaccharide (COS) in Vitro and in Vivo: Permeability Characterization in Caco-2 Cells Monolayer and Pharmacokinetics Properties in Rats.  Journal of Ocean University of China,  21  (3): (782-788).  [PMID:] [10.1007/s11802-022-5088-x]
12. Wu Wanbao, Bo Yiyang, Li Deping, Liang Yihong, Zhang Jichuan, Cao Miaomiao, Guo Ruitian, Zhu Zhenye, Ci Lijie, Li Mingyu, Zhang Jiaheng.  (2022)  Safe and Stable Lithium Metal Batteries Enabled by an Amide-Based Electrolyte.  Nano-Micro Letters,  14  (1): (1-14).  [PMID:35020069] [10.1007/s40820-021-00780-7]
13. Xue Jiang, Xiaoyao Liu, Qi Yu, Wenwen Shen, Xifan Mei, He Tian, Chao Wu.  (2021)  Functional resveratrol-biodegradable manganese doped silica nanoparticles for the spinal cord injury treatment.  Materials Today Bio,      [PMID:34938991] [10.1016/j.mtbio.2021.100177]
14. Xiaona Hu, Ziruo Zhou, Lijun Han, Shujing Li, Wei Zhou.  (2020)  Preparation and characterization of phloretin by complexation with cyclodextrins.  NEW JOURNAL OF CHEMISTRY,  44  (14): (5218-5223).  [PMID:] [10.1039/C9NJ06228A]
15. Zerong Li, Wenmei Qiao, Chenghao Wang, Heqiao Wang, Mengchao Ma, Xinyu Han, Jingling Tang.  (2020)  DPPC-coated lipid nanoparticles as an inhalable carrier for accumulation of resveratrol in the pulmonary vasculature, a new strategy for pulmonary arterial hypertension treatment.  DRUG DELIVERY,      [PMID:32397765] [10.1080/10717544.2020.1760962]
16. Zenghui Xie, Yanli Chen, Lanyun Zhang, Xujia Hu.  (2019)  Magnetic molecularly imprinted polymer combined with high performance liquid chromatography for selective extraction and determination of the metabolic content of quercetin in rat plasma.  JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,      [PMID:31566488] [10.1080/09205063.2019.1675224]
17. Dandan Wang, Liangxiao Zhang, Yueqing Xu, Xin Qi, Xuefang Wang, Xiupin Wang, Qi Zhang, Peiwu Li.  (2019)  Optimization of an Ultrasound-Assisted Extraction for Simultaneous Determination of Antioxidants in Sesame with Response Surface Methodology.  Antioxidants,  (8): (321).  [PMID:31430991] [10.3390/antiox8080321]
18. Yufeng Chen, Fan Xue, Guobin Xia, Zhenlei Zhao, Chun Chen, Yunhong Li, Ying Zhang.  (2019)  Transepithelial transport mechanisms of 7,8-dihydroxyflavone, a small molecular TrkB receptor agonist, in human intestinal Caco-2 cells.  Food & Function,  10  (8): (5215-5227).  [PMID:31384856] [10.1039/C9FO01007F]
19. Yin Ying, Cheng Jiang, Meiling Zhang, Jiye Jin, Shuyu Ge, Xiaodong Wang.  (2019)  Phloretin protects against cardiac damage and remodeling via restoring SIRT1 and anti-inflammatory effects in the streptozotocin-induced diabetic mouse model.  Aging-US,      [PMID:31076562] [10.18632/aging.101954]
20. Meihui Fan, Huafang Ding, Guowen Zhang, Xing Hu, Deming Gong.  (2019)  Relationships of dietary flavonoid structure with its tyrosinase inhibitory activity and affinity.  LWT-FOOD SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.lwt.2019.02.076]
21. Hai-Na Yu, Xin-Yan Liu, Shuai Gao, Bin Sun, Hong-Bo Zheng, Mei Ji, Ai-Xia Cheng, Hong-Xiang Lou.  (2018)  Structural and biochemical characterization of the plant type III polyketide synthases of the liverwort Marchantia paleacea.  PLANT PHYSIOLOGY AND BIOCHEMISTRY,      [PMID:29428820] [10.1016/j.plaphy.2018.01.030]
22. Jiming Wu, Jinghan Li, Jin Zhang, Xinyue Hu, Dahong Yao, Liang Ma, Liang Ouyang, Xinhui Pan, Jian Huang, Ruichao Lin, Jinhui Wang.  (2015)  In silico identification and experimental validation of diuresis compounds from Euphorbia lathyris for potential UT-B inhibitors.  Journal of the Taiwan Institute of Chemical Engineers,      [PMID:] [10.1016/j.jtice.2015.10.045]
23. Siyang Chen, Wenxiu Zhu, Yiqun Zhan, Xiaodong Xia.  (2024)  Antibacterial Activity of Phloretin Against Vibrio parahaemolyticus and Its Application in Seafood.  Foods,  13  (22): (3537).  [PMID:39593953] [10.3390/foods13223537]
24. Cong Liu, Weihua Liu, Qianqian Wang, Chun Wang, Qiuhua Wu.  (2025)  Construction of novel hyper-crosslinked polymers with adjustable hydrophilicity for efficient extraction of nitroimidazoles.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:39855025] [10.1016/j.chroma.2025.465702]
25. Chang Tang, Rui Tong, Guoqing Deng, Jing Yang, Yi Zhang, Zhifeng Cai.  (2024)  Fluorescent carbon dots for highly sensitive diosmetin sensing.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2024.110362]
26. Xiaomeng Zhang, Xinquan Tian, Junyu Luo, Xiaoyang Wang, Shoupu He, Gaofei Sun, Ruidan Dong, Panhong Dai, Xiao Wang, Zhaoe Pan, Baojun Chen, Daowu Hu, Liru Wang, Baoyin Pang, Aishuang Xing, Guoyong Fu, Baoquan Wang, Jinjie Cui, Lei Ma, Xiongming Du.  (2025)  Identification of UDP-glucosyltransferase involved in the biosynthesis of phloridzin in Gossypium hirsutum.  PLANT JOURNAL,  121  (3): (e17248).  [PMID:39935137] [10.1111/tpj.17248]
27. Jiaqi Wen, Shuling Chen, Le Deng, Xinru Chen, Xiaoyu Jiang, Xing Hu, Deming Gong, Guowen Zhang.  (2024)  Inhibitiory mechanism of phloretin on xanthine oxidase and its synergistic effect with allopurinol and febuxostat.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2024.104720]
28. Xia Yang, Yun Wang, Yan Sun, Jiali Guo, Zhaojun Geng, Bingyao Wei, Peiqin Li, Guanghui Tang.  (2025)  Integrated transcriptomics and metabolomics revealed the role of the flavonoid pathway in the resistance of Zanthoxylum bungeanum against leaf rust.  SCIENTIA HORTICULTURAE,      [PMID:] [10.1016/j.scienta.2025.113990]
29. Yongsong Zhang, Na Xia, Zhenzhen Ding, Jingjing Song, Yanan Zhang, Cao Li, Xuesong Huang, Zuoshan Feng.  (2025)  Preparation, structural changes and functional properties of the covalent complexes of almond protein and phloretin.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39765300] [10.1016/j.ijbiomac.2024.139322]
30. Yushi Wei, Jianmei Wu, Xi Peng, Xing Hu, Deming Gong, Guowen Zhang.  (2024)  Protein glycosylation inhibitory effects and mechanisms of phloretin and phlorizin.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2024.104971]
31. Jiawei Li, Chengyu Hong, Hao Zhang, Jiaqi Zhang, Ruixue Zhai, Bin Fei, Chao Zhou.  (2024)  Sustainable, transparent, strong toughness, UV resistance, and anti-corrosion properties of cashew shell oil-based waterborne polyurethane network derived from phloretin and sorbitan monooleate-based siloxane.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.151506]
32. Zhou Zhixin, Zhou Cheng, Liu Jia, Yuan Ye, Yao Chundong, Liu Miaodeng, Deng Lixue, Sun Jia, Chen Zuoyu, Wang Lin, Wang Zheng.  (2024)  Tumor specific in situ synthesis of therapeutic agent for precision cancer therapy.  JOURNAL OF NANOBIOTECHNOLOGY,  22  (1): (1-18).  [PMID:39385273] [10.1186/s12951-024-02825-6]
33. Zhixiao Liu, Yuhang Zhao, Mingli Yi, Lintao Liao, Yangyang Huang, Guangqiu Lei, Gao Hu, Mayu Lan, Huiping Li, Zhiming Mi.  (2025)  Preparation of high-permeance polyester nanofiltration membranes utilizing biobased phloretin derivatives for antibiotic separation.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2025.124458]
34. Huining Su, Xunan Jing, Heng Sun, Zingcheng Liu, Daquan Wang, Lingjie Meng.  (2025)  Multifunctional Nanocomposite Hydrogel Dressings with Excellent Antibacterial and Angiogenesis Properties for Effective Treatment of Diabetic Wounds.  ACS Applied Materials & Interfaces,      [PMID:40675128] [10.1021/acsami.5c08356]
35. Shouguang Wang, Xiaofei Zhang, Dunmin Zhuang, Lina Dong, Bo Li.  (2025)  Mn2+-coordinated hyaluronic acid modified nanoparticles for phloretin delivery: Breast cancer treatment.  Colloid and Interface Science Communications,      [PMID:] [10.1016/j.colcom.2025.100854]
36. Jiaqi Wen, Yijing Liao, Deming Gong, Guowen Zhang.  (2025)  Effects of unsaturated fatty acids on the interaction between phloretin and xanthine oxidase: Inhibitory activity, binding ability and molecular structure.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2025.106669]
37. Mokhtar Fathi, Kianoosh Zarrinkavyani, Zahra Biranvand, Morteza Aghil Al Abd.  (2025)  Effect of Phloretin on Antioxidant Status, Inflammatory Cytokines, Blood and Biochemical Indices, Cecal Microbial Load, and Growth Performance in Broiler Chickens Subjected to Pulmonary Arterial Hypertension.  POULTRY SCIENCE,      [PMID:40779808] [10.1016/j.psj.2025.105265]
38. Qianqian Liang, Xin Jiang, Dajun Wang, Shumin Zhang, Qifei Hua, Wenzheng Shi.  (2025)  Screening of natural myofibril-bound serine protease inhibitors based on molecular docking and their effects on the quality of surimi gels.  FOOD CHEMISTRY,      [PMID:40580600] [10.1016/j.foodchem.2025.145314]
39. Runze Wang, Wenting Cheng, Hailong Tian, Mengchao Dong, Weifeng He, Xie Wang, Yingying Zou.  (2025)  Thymopentin-integrated self-assembling nanoplatform for enhanced photo-immunotherapy in diabetic wound healing.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:40580559] [10.1016/j.jcis.2025.138264]
40. Teng Xiao, Fanghong Wang, Ye Li, Gaoyang Lin, Xiaochen Wu.  (2025)  Phloretin-loaded selenium nanoparticles for alleviating cisplatin-induced acute kidney injury via inhibition of the cGAS/STING pathway.  International Journal of Pharmaceutics-X,      [PMID:41216270] [10.1016/j.ijpx.2025.100427]
41. Guangyao Li, Weilun Zhang, Zhiwei Deng, Changmei Liu, Zhengshan Luo, Yan Zhang, Zhenbo Yuan, Yijian Rao.  (2025)  Engineering C-glycosyltransferase UGT708A60 to enhance the activity and thermostability for the highly efficient biosynthesis of nothofagin.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2025.107952]
42. Li Jie, Jiang Enhui, Zhang Mengyang, Pan Chuanying, Lei Chuzhao, Han Lin, Lan Xianyong.  (2025)  Phloretin inhibits ferroptosis by restoring the antioxidant capacity of bovine adipose and muscle cells via the AMPK-PPAR signaling pathway.  Stress Biology,  (1): (74).  [PMID:41354995] [10.1007/s44154-025-00263-4]
43. Dan Yu, Fangmin Chen, Jinliang Deng, Zhe Pu, Xinyao Yang.  (2025)  Serovar-specific lipopolysaccharide modifications induced by phytogenic biocide drive differential bacterial mobility in soil.  APPLIED SOIL ECOLOGY,      [PMID:] [10.1016/j.apsoil.2025.106725]
44. Chong Gao, Wei Liu, Sai-Hu Liu, Shuang Zheng, Chen-Yu Wang, Xu Dai, Li-Hua Lian, Zhen-Yu Cui, Ji-Xing Nan, Yan-Ling Wu.  (2026)  Trigonelline regulates glycolysis and energy metabolism during hepatic fibrosis via Glut-1-HIF-1α axis: Focusing the interaction of macrophages and HSCs.  PHYTOMEDICINE,      [PMID:41579590] [10.1016/j.phymed.2026.157854]
45. Siyang Chen, Jinhui Jia, Jian Du, Ningbo Qin, Xiaodong Xia.  (2026)  Fabrication of a zein-phloretin complex and nanoparticles: interaction mechanism and characterization.  RSC Advances,  16  (9): (7717-7725).  [PMID:41659321] [10.1039/D5RA08898D]
Solution Calculators
Reviews

Customer Reviews

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.