PLX5622 - Moligand™, 10mM in DMSO , Inhibitor of KIT proto-oncogene; receptor tyrosine kinase, CAS No.1303420-67-8, Inhibitor of KIT proto-oncogene; receptor tyrosine kinase

CAS: 1303420-67-8 Cat. No.: P409126 Summenformel: C₂₁H₁₉F₂N₅O Molekulargewicht: 395.41 PubChem CID: 52936034

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

3-​Pyridinemethanamine, 5-​fluoro-​N-​[6-​fluoro-​5-​[(5-​methyl-​1H-​pyrrolo[2,​3-​b]​pyridin-​3-​yl)​methyl]​-​2-​pyridinyl]​-​2-​methoxy-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

PLX5622 PLX5622 is a highly selective CSF-1R inhibitor (IC50 < 10 nmol/L), showing > 20-fold selectivity over KIT and FLT3.
In vitro

In vivo

In vivo PLX5622 demonstrates desirable PK properties in mice, rats, dogs, and monkeys, with a brain penetrance of ~20%. PLX5622 has low systemic clearance, moderate volume of distribution, and favorable oral bioavailability (F > 30%) in all four species. PLX5622 is a useful compound for investigating microglial dynamics. It allows for the sustained and specific elimination of microglia, preceding and during pathology development of Alzheimer’s disease (AD). Long-term PLX5622-mediated microglial depletion is highly robust, sustainable, and specific to the microglial compartment.
Cell Data

cell lines：Ba/F3 cells expressing JAK2V617F (Ba/F3-EpoR-V617F) and MPLW515L (Ba/F3-W515L) mutants.

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Synonyme

3-​Pyridinemethanamine, 5-​fluoro-​N-​[6-​fluoro-​5-​[(5-​methyl-​1H-​pyrrolo[2,​3-​b]​pyridin-​3-​yl)​methyl]​-​2-​pyridinyl]​-​2-​methoxy-

Spezifikationen & Reinheit

Moligand™, 10mM in DMSO

Biochemische und physiologische Mechanismen

PLX5622 is a highly selective CSF-1R inhibitor (IC50 < 10 nmol/L), showing\u2009>\u200920-fold selectivity over KIT and FLT3.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

INHIBITOR

Mechanismus der Wirkung

Inhibitor of KIT proto-oncogene; receptor tyrosine kinase

Produkteigenschaften

• ALogP: 4.577
• HBD-Zahl: 2
• Rotationsfähige Bindung: 6

Namen und Kennungen

• Isomere SMILES: CC1=CC2=C(NC=C2CC3=C(N=C(C=C3)NCC4=C(N=CC(=C4)F)OC)F)N=C1
• Alternative CAS-Nummer: 1303420-67-8
• PubChem CID: 52936034
• MeSH-Eintrag: PLX5622
• Molekulargewicht: 395.41

Zugehörige Ziele (menschlich)

KIT Tclin Mast/stem cell growth factor receptor Kit (0 Activities)

Discover Target: KIT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemische und physikalische Eigenschaften

• DMSO (mg/ml) Maximale Löslichkeit: 79
• DMSO (mM) Maximale Löslichkeit: 199.792620318151
• Wasser (mg/ml) Maximale Löslichkeit: ＜1

Referenzen

1. Hanqi Wang, Yijun Chen, Junna Chang, Zhen Liu, Yang Yu.  (2026)  FPR2 deficiency alleviates LPS-induced depressive-like behaviors in mice by suppressing the microglial CSF1/NLRP3 inflammasome pathway.  Journal of Neuroinflammation,      [PMID:42458515] [10.1186/s12974-026-03963-4]

Häufig gestellte Fragen

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1303420-67-8, the molecular formula is C21H19F2N5O, and the molecular weight is 395.41 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.