Polydatin - Moligand™,10mM in DMSO , CAS No.65914-17-2

CAS: 65914-17-2 Cat. No.: P408531 Molecular Weight: 390.38 EC Number: 683-198-7

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Piceid | β-D-Glucopyranoside, 3-hydroxy-5-[2-(4-hydroxyphenyl)ethenyl]phenyl

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Polydatin Polydatin (Piceid) is a crystal component extracted from the root stem of perennial herbage Polygonum Cuspidatum Sieb.et Zucc.
In vitro

Polydatin, known as a PLA2 inhibitor, reduces Phospholipase A2 (PLA2) activity and sPLA2-IIA mRNA expression and mitigates LPS-induced lung injury by increasing increased Clara cell secretory protein (CCSP) expression.

In vivo

Pretreatment with Polydatin (15, 45, and 100 mg/kg) dose-dependently reduces sepsis-induced mortality and lung injury in cecal ligation and puncture (CLP-)induced sepsis mice through inhibiting CLP-induced serum tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) production, lung cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase isoform (iNOS) protein expressions and NF-kappaB activation. LD50: Mice 1g/kg (i.p.)
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Synonyms

Piceid | β-D-Glucopyranoside, 3-hydroxy-5-[2-(4-hydroxyphenyl)ethenyl]phenyl

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Polydatin (Piceid) is a crystal component extracted from the root stem of perennial herbage Polygonum Cuspidatum Sieb.et Zucc.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Names and Identifiers

• Isomeric SMILES: C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O)O
• Alternate CAS: 27208-80-6
• Molecular Weight: 390.38
• Reaxy-Rn: 1604738
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1604738&ln=

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro
• Melt Point(°C): 223-226°C

References

1. Shilin Zhou, Yuxuan Sun, Kaidi Wang, Xintao Gao, Kehong Dong, Jing Wang, Xiaochen Wu, Chuanlong Guo.  (2023)  Polyvinylpyrrolidone-Polydatin nanoparticles protect against oxaliplatin induced intestinal toxicity in vitro and in vivo.  FOOD AND CHEMICAL TOXICOLOGY,      [PMID:38160781] [10.1016/j.fct.2023.114427]

2. Qing Yao, Jinyao Ye, Yahui Chen, Lihui Huang, Lining Sun, Zhinan He, Jianing Wu, Yingyi Zhao, Xinyu Zhao, Aimin Cai, Xiandan Chen, Hailun Zheng, Aliaksei Sysa, Congying Xie, Ruijie Chen, Longfa Kou.  (2023)  Modulation of glucose metabolism through macrophage-membrane-coated metal-organic framework nanoparticles for triple-negative breast cancer therapy.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.148069]

3. Yajie Zhang, Changjiao Shang, Chaofan Sun, Lingling Wang.  (2023)  Simultaneously regulating absorption capacities and antioxidant activities of four stilbene derivatives utilizing substitution effect: A theoretical and experimental study against UVB radiation.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:37678043] [10.1016/j.saa.2023.123325]

4. Kang Du, Qun Zhou, Ziwen Wang, Chou Mo, Wanwen Dong, Ning Wei, Wenshen Zhong, Yuejiao You, Yifei Wang, Zhiping Wang.  (2023)  Polydatin ameliorates inflammation and oxidative stress associated with MSU-induced gouty arthritis in mice by regulating PPAR-γ and ferritin activation.  LIFE SCIENCES,      [PMID:37209866] [10.1016/j.lfs.2023.121766]

5. Zhengming Xu, Shuang Liu, Huining Lai, Lijun You, Zhengang Zhao.  (2023)  Green-Efficient Enzymatic Synthesis and Characterization of Liposoluble 6′/6″-O-Lauryl Phenolic Glycosides with Enhanced Intestinal Permeability.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:37167604] [10.1021/acs.jafc.3c00527]

6. Chen-Xi He, Yu-Shi Shen, Mei-Yan Ling, Xiao-Hui Yao, Tao Chen, Wei-Guo Zhao, Dong-yang Zhang.  (2023)  A porous directional channel xylem reactor based on a continuous fluid catalysis process applied to the conversion of polydatin to resveratrol.  Sustainable Chemistry and Pharmacy,      [PMID:] [10.1016/j.scp.2023.101082]

7. Xu Lingfeng, Zou Ying, Wu Kui, Han Runlin, Huang Yanrong, Yi Xiuguang.  (2023)  Polydatin-based natural product as an activatable molecular sensor toward viscosity detection in liquid.  Journal of Food Measurement and Characterization,  17  (4): (3918-3926).  [PMID:] [10.1007/s11694-023-01920-w]

8. Qiaoyu He, Yumeng Shi, Hong Xing, Qian Tang, Jing Liu, Chunxia Li, Han Zhang, Boli Zhang, Junhua Zhang, Xiaopeng Chen.  (2022)  Modulating effect of Xuanfei Baidu granule on host metabolism and gut microbiome in rats..  Frontiers in Pharmacology,      [PMID:36147334] [10.3389/fphar.2022.922642]

9. Li-Ming Yu, Xue Dong, Ning Li, Hui Jiang, Ji-Kai Zhao, Yin-Li Xu, Deng-Yue Xu, Xiao-Dong Xue, Zi-Jun Zhou, Yu-Ting Huang, Qiu-Sheng Zhao, Zhi-Shang Wang, Zong-Tao Yin, Hui-Shan Wang.  (2022)  Polydatin attenuates chronic alcohol consumption-induced cardiomyopathy through a SIRT6-dependent mechanism.  Food & Function,  13  (13): (7302-7319).  [PMID:35726783] [10.1039/D2FO00966H]

10. Yanan Chen, Yue Li, Peilu Jia, Shuli Ji, Hao Zhang, Tian Wang.  (2022)  Polydatin Attenuates Intra-Uterine Growth Retardation-Induced Liver Injury and Mitochondrial Dysfunction in Weanling Piglets by Improving Energy Metabolism and Redox Balance.  Antioxidants,  11  (4): (666).  [PMID:35453351] [10.3390/antiox11040666]

11. Zilong Chen, Hongdong Liu, Jie Chen, Weifeng Zhu, Yong Liu, Jianxin Min, Xiaotian Chen, Bin Li, Xin Yang.  (2021)  Separation and enrichment of sibiskoside from Sibiraea angustat with magnetic surface dummy template molecularly imprinted polymers.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,      [PMID:34224966] [10.1016/j.jchromb.2021.122767]

12. Shengyu Sun, Yourui Zou, Shaocai Hao, Zhanfeng Niu, Liang Wu.  (2021)  Polydatin inhibits LPS-induced inflammatory response in BV2 microglia by disrupting the formation of lipid rafts.  IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY,      [PMID:33509007] [10.1080/08923973.2020.1867999]

13. Lijuan Wang, Liji Huang, Nan Li, Junjun Miao, Wei Liu, Jiangyi Yu.  (2019)  Ameliorative effect of polydatin on hyperglycemia and renal injury in streptozotocin-induced diabetic rats.  CELLULAR AND MOLECULAR BIOLOGY,  65  (7):   [PMID:] [10.14715/cmb/2019.65.7.10]

14. Jianle Wang, Chongan Huang, Zongze Lin, Xiangxiang Pan, Jiaoxiang Chen, Gang Zheng, Naifeng Tian, Yingzhao Yan, Zengjie Zhang, Jianing Hu, Pu Cheng, Xiangyang Wang, Xiaolei Zhang.  (2018)  Polydatin suppresses nucleus pulposus cell senescence, promotes matrix homeostasis and attenuates intervertebral disc degeneration in rats.  JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,  22  (11): (5720-5731).  [PMID:30358118] [10.1111/jcmm.13848]

15. Meihui Chen, Yu Hou, Dingkun Lin.  (2015)  Polydatin Protects Bone Marrow Stem Cells against Oxidative Injury: Involvement of Nrf 2/ARE Pathways.  Stem Cells International,      [PMID:27022401] [10.1155/2016/9394150]

16. Benguo Liu, Yun Li, Huizhi Xiao, Yonglan Liu, Haizhen Mo, Hanjun Ma, Guizhao Liang.  (2015)  Characterization of the Supermolecular Structure of Polydatin/6-O-α-Maltosyl-β-cyclodextrin Inclusion Complex.  JOURNAL OF FOOD SCIENCE,  80  (6): (C1156).  [PMID:25916244] [10.1111/1750-3841.12845]

17. Li Zhang, Yuanyuan Li, Zhiwen Gu, Yuyue Wang, Mei Shi, Yun Ji, Jing Sun, Xiaopeng Xu, Lirong Zhang, Jingtin Jiang, Weifeng Shi.  (2015)  Resveratrol Inhibits Enterovirus 71 Replication and Pro-Inflammatory Cytokine Secretion in Rhabdosarcoma Cells through Blocking IKKs/NF-κB Signaling Pathway.  PLoS One,  10  (2): (e0116879).  [PMID:25692777] [10.1371/journal.pone.0116879]

18. Yanhong Bi, Ruiping Fu, Weiliang Hua, Xinyu Xiong, Chun Zhu, Xiaobao Nie, Zhaoyu Wang.  (2025)  An empirical exploration of the capacity of choline chloride/lactic acid eutectics to extract and stabilize natural polyhydroxy compounds.  FOOD CHEMISTRY,      [PMID:40120314] [10.1016/j.foodchem.2025.143873]

19. Tao Ma, W. Wu, Y. Tu, N. Zhang, Q. Diao.  (2020)  Resveratrol affects in vitro rumen fermentation, methane production and prokaryotic community composition in a time- and diet-specific manner.  Microbial Biotechnology,  13  (4): (1118-1131).  [PMID:32297431] [10.1111/1751-7915.13566]

20. Shujing Li, Li Yuan, Bing Zhang, Wei Zhou, Xinrui Wang, Dongsheng Bai.  (2018)  Photostability and antioxidant activity studies on the inclusion complexes of trans-polydatin with β-cyclodextrin and derivatives.  RSC Advances,  8  (46): (25941-25948).  [PMID:35541971] [10.1039/C8RA04778B]