Pomalidomide-PEG₆-CO₂H - ≥98% , CAS No.2225148-49-0

CAS: 2225148-49-0 Cat. No.: P486908 Summenformel: C₂₈H₃₉N₃O₁₂ Molekulargewicht: 609.62 PubChem CID: 139034004

GRADE & PURITY ≥98%

Synonyms

1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid | Crosslinker−E3 Ligase ligand conjugate | Pomalidomide-PEG6-COOH

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Übersicht

Description

Protein degrader builiding block Pomalidomide-PEG6-CO2H enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Specifications

Synonyme

1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid | Crosslinker−E3 Ligase ligand conjugate | Pomalidomide-PEG6-COOH

Spezifikationen & Reinheit

≥98%

Storage

Store at -20°C,Argon charged

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Reinheit

≥98%

Namen und Kennungen

• Pubchem Sid: 504773551
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773551
• Kanonisches Lächeln: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCOCCOCCOCCOCCC(=O)O
• IUPAC Name: 3-[2-[2-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChIKey: NBDBXIANAMQQQU-UHFFFAOYSA-N
• INCHI: 1S/C28H39N3O12/c32-23-5-4-22(26(35)30-23)31-27(36)20-2-1-3-21(25(20)28(31)37)29-7-9-39-11-13-41-15-17-43-19-18-42-16-14-40-12-10-38-8-6-24(33)34/h1-3,22,29H,4-19H2,(H,33,34)(H,30,32,35)
• PubChem CID: 139034004
• Molekulargewicht: 609.62

Chemische und physikalische Eigenschaften

• Empfindlichkeit: Moisture sensitive
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable