PPZ-A10 - ≥98% , CAS No.2941268-67-1

CAS: 2941268-67-1 Cat. No.: P1440445 Summenformel: C₅₆H₁₁₄N₆O₂ Molekulargewicht: 903.54

QUALITÄT & REINHEIT ≥98%

Storage

Store at 2-8°C

Shipped In

Wet ice

Übersicht

PPZ-A10 is a ionizable lipid that delivered mRNA preferentially to liver and spleen immune cells.

Spezifikationen

Spezifikationen & Reinheit

≥98%

Storage

Store at 2-8°C

Verschickt in

Wet ice

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Reinheit

≥98%

Namen und Kennungen

Molekulargewicht

903.54

Application Protocols

No validated application protocols are provided for this item. The following general practices may assist in deploying small molecules in research settings:

• Stock solution: Dissolve in dry DMSO to a convenient concentration (e.g., 10 or 20 mM); vortex and sonicate gently if needed. Filter through 0.22 µm PTFE if particulate persists.
• Plate handling: Pre-dispense DMSO stocks into assay plates using calibrated acoustic or pin tools; seal to limit evaporation. Normalize DMSO across wells.
• Dose–response: Prepare serial dilutions (e.g., 1:3 or 1:2) to define IC50/EC50 ranges; include vehicle controls.
• Stability: Minimize time at room temperature; protect from light if chromophoric behavior is suspected.
• Data capture: Record batch/lot, exact solvent, concentration, and dispense method for reproducibility.

For any specific, validated protocol requirements, refer to the CoA or contact technical support.

Biological Roles

No biological mechanism, target class, or pathway information is provided for PPZ-A10. Without a disclosed structure or annotation, specific biological roles cannot be asserted.

General guidance for small-molecule tools:

• If PPZ-A10 is intended as a screening hit or library member, determine activity profiles empirically across your panel of interest (e.g., enzyme inhibition, receptor binding, cell viability) and confirm results with orthogonal assays.
• Record and report exact lot, concentration, solvent, and exposure time to ensure reproducibility.
• For putative mechanism studies, complement phenotypic readouts with target engagement assays (e.g., CETSA, SPR, BRET) when applicable.

Note: All uses are for research only; no clinical, diagnostic, or veterinary applications.

Buffer Applications

This product is a small-molecule research compound, not a buffering agent. No buffer system specifications or pKa values are provided, and PPZ-A10 is not typically used to make buffers.

Practical notes (general):

• When preparing aqueous assay media containing PPZ-A10, maintain physiological pH (e.g., 7.2–7.4) with standard buffers (HEPES, PBS) and keep DMSO ≤0.5–1% v/v if possible.
• If pH-dependent solubility is observed, adjust pH using conventional buffers rather than attempting to use the compound itself as a buffer component.

Green Alternatives

Because the structure and solvent needs of PPZ-A10 are not disclosed, green chemistry considerations focus on solvent choices and handling (general guidance):

• Prefer greener solvents when compatible: ethanol, isopropanol, ethyl acetate, 2-MeTHF for workups or recrystallizations (if performing any purification), instead of chlorinated solvents.
• For assay stocks, consider lower-toxicity co-solvents (ethanol, PEG-400/water) if the compound’s solubility allows, to reduce DMSO usage.
• Minimize waste: prepare the smallest feasible volumes of concentrated stocks; design screening plates to limit dead volume.
• Energy and cold-chain: Consolidate shipments and store at stipulated 2–8°C to minimize freeze–thaw cycling and energy consumption.

Tradeoffs (general):

• Greener alcohols may offer lower solvency than DMSO/DMF; achieving the same concentration could be impractical for lipophilic scaffolds.
• 2-MeTHF and CPME are greener ethers but may not be suitable for aqueous assay dilution; verify miscibility and assay tolerance.

Pharmaceutical Uses

No pharmacopeial status, excipient role, or formulation use is provided for PPZ-A10. This product is supplied strictly for research use and is not intended for clinical or manufacturing applications.

General considerations for formulation research (non-clinical, lab-only):

• For in vitro studies, typical stock solutions are prepared in DMSO and diluted into culture media or assay buffers immediately before use.
• If advanced pre-formulation studies are required (e.g., solubility screening in biorelevant media), establish chemical stability and assay compatibility first. Do not extrapolate to clinical settings.
• Avoid any implication of therapeutic use; no clinical claims are made or supported.

Physical Properties

Item-specific physicochemical parameters were not provided. Do not treat the following as specifications; consult the CoA/Spec Sheet for authoritative values.

• Appearance: Not specified for this item; refer to CoA/Spec Sheet.
• Melting point (MP): Not specified for this item; refer to CoA/Spec Sheet.
• Boiling point (BP): Not specified for this item; refer to CoA/Spec Sheet.
• Density: Not specified for this item; refer to CoA/Spec Sheet.
• LogP/logD, pKa, refractive index: Not specified for this item; refer to CoA/Spec Sheet.
• Solubility: Not specified for this item; refer to CoA/Spec Sheet.

General laboratory guidance (literature/general):

• Screening compounds are commonly supplied as solids or pre-dissolved DMSO stocks at 10–50 mM. Typical dissolution solvents include DMSO, DMF, ethanol, or aqueous buffers with co-solvent (depending on ionization state).
• For unknown solubility, a stepwise approach is recommended: attempt dissolution in dry DMSO, then prepare serial dilutions into assay media to keep final DMSO ≤0.5–1% v/v for cell-based assays (general practice). Filter sterilize (0.22 µm) if required for biological assays.
• If compound is ionizable, pH-adjusted aqueous buffers (pH 2–3 for bases; pH 9–10 for acids) with minimal co-solvent can improve solubility. Verify chemical stability via LC–MS or HPLC.

Quality and Grades

• Grade/Purity: Not specified for this item; refer to CoA/Spec Sheet.

Context and expectations (general guidance for screening compounds):

• Screening-grade small molecules are typically supplied at high chemical purity (commonly ≥95% by HPLC) to ensure assay reliability; exact purity, analytical method (HPLC/LC–MS/NMR), and water/volatile content must be confirmed on the CoA.
• If provided as a solid, residual solvents and counter-ion identity (for salts) should be documented on the CoA. If provided as solution (e.g., 10 mM in DMSO), solution concentration and water content should be verified by analytical data.
• UV-Vis background absorbance and fluorescence can interfere with readouts; low-UV/high-purity materials are preferred for optical assays—request spectral scans if your assay is photometric.
• Batch-to-batch consistency: Request lot-specific analytical traces (HPLC chromatogram, LC–MS, 1H NMR) for cheminformatics and QA archiving.

Reaction and Applications

This item is positioned as a small-molecule research compound rather than a synthetic reagent. No manufacturer application text was provided.

• Research use: For in vitro screening, target validation experiments, or as a tool compound placeholder where structure is handled under a code. All uses are strictly for research; no clinical/diagnostic use.
• If structure becomes available, suitability for reactions (e.g., cross-coupling, amide formation, N-alkylation) would depend on functional groups present. Without structural data, no specific synthetic reaction recommendations can be made.
• Practical tips (general):
  • Verify identity and purity by LC–MS/HPLC before critical screening campaigns.
  • Establish stock solution stability (freeze–thaw, bench-top) experimentally; monitor by LC–MS at 0, 24, 48, and 72 h.
  • For cell-based assays, evaluate cytotoxicity windows and solvent tolerability in a pilot plate.
• Data integrity: Maintain lot-to-lot traceability; record exact stock concentrations, solvents, and date of preparation.

Reaction Conditions

Specific reaction conditions are not applicable as this product is positioned for screening rather than as a reagent, and no structure is provided.

General experimental considerations (if using in assays):

• Stock preparation: Commonly 10–50 mM in anhydrous DMSO; confirm solubility and stability by LC–MS.
• Dilution: Prepare working solutions immediately before use; keep final organic co-solvent below the tolerance of your assay system.
• Stability checks: Store aliquots at 2–8°C (short term) as directed; avoid multiple freeze–thaw cycles. For longer-term projects, consider frozen aliquots if stability allows (verify experimentally).

Note: If you plan to use PPZ-A10 as a substrate, inhibitor, or ligand in biochemical assays, determine optimal concentration ranges empirically via dose–response studies.

Safety and Handling

No item-specific GHS classification or hazard statements were provided. Always consult the product SDS for definitive safety information.

• Signal Word: Not specified for this item; refer to CoA/Spec Sheet/SDS.
• GHS Classification: Not specified for this item; refer to SDS.
• H-Statements and Pictograms: Not specified for this item; refer to SDS.

General laboratory precautions (general guidance):

• Handle in a chemical fume hood; avoid inhalation, ingestion, and skin/eye contact.
• Recommended PPE: lab coat, safety glasses, and appropriate chemical-resistant gloves (e.g., nitrile). Use splash protection when preparing concentrated stock solutions.
• Incompatibilities are compound-dependent; in absence of structural data, avoid strong oxidizers/reducers and extreme pH until stability is confirmed.
• First aid (overview; defer to SDS): rinse eyes/skin with water for ≥15 minutes upon contact; if inhaled, move to fresh air; if ingested, seek medical attention and provide SDS.
• Waste: Collect solutions and solids as hazardous waste per institutional and local regulations.
• Special risks: If dissolved in DMSO/DMF, remember these solvents can enhance dermal absorption—avoid skin exposure.

Solvent Selection

Item-specific solubility is not provided. The following outlines a pragmatic workflow for small-molecule dissolution (general guidance):

• Primary solvent: Anhydrous DMSO is the default for discovery compounds owing to broad solvency and biological assay compatibility at low final % v/v.
• Secondary solvents: DMF, ethanol, methanol, acetonitrile. For aqueous work, consider co-solvent systems (e.g., 5–20% DMSO or ACN in buffer) after confirming assay tolerance.
• pH-mediated solubility: For weak bases, acidify with volatile acids (e.g., HCl in ethanol/water) to form salts; for weak acids, basify with ammonium hydroxide or appropriate buffers. Confirm no degradation by LC–MS.
• Filtration: Use 0.22 µm PTFE or PVDF for organic-rich solutions; use nylon/PES only if solvent-compatible.
• Avoid adsorption: For sticky/greasy compounds, prepare at higher concentration in DMSO and dilute immediately before use to reduce plastic binding.
• Light/air sensitivity: If unknown, prepare solutions under inert gas and protect from light with amber vials; check stability over 24–72 hours.

Comparison (general):

• DMSO vs ethanol: DMSO solubilizes a broader polarity range; ethanol offers easier evaporation but lower solvency for very lipophilic molecules.

Storage and Reconstitution

• Storage Conditions (from product data): Store at 2–8°C.
• Shipping: Shipped on wet ice (from product data).
• Appearance: Not specified for this item; refer to CoA/Spec Sheet.

General handling (applicable to screening compounds):

• Upon receipt, allow the container to equilibrate to room temperature in a desiccator before opening to avoid moisture condensation.
• If provided as a solid: Prepare concentrated stock solutions in dry DMSO. Aliquot into inert, airtight vials to minimize freeze–thaw and headspace oxygen. Label with lot, concentration, and date.
• If provided as a solution: Verify concentration and integrity upon arrival; store tightly capped at 2–8°C as directed and avoid prolonged exposure to ambient light and air.
• Reconstitution solvent selection: Start with anhydrous DMSO; if aqueous solutions are required, dilute immediately before use into buffered media while keeping DMSO within assay limits.
• Stability: Item-specific shelf-life and solution stability are not specified for this item; refer to CoA/Spec Sheet. Confirm ongoing suitability by periodic LC–MS/HPLC checks.

Structure and Identity

This product is supplied as a small-molecule screening compound under the code name PPZ-A10. Item-specific structural identifiers are not provided in the product data.

• SKU: P1440445
• Product Name: PPZ-A10
• CAS: 2941268-67-1
• Molecular Formula: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular Weight: Not specified for this item; refer to CoA/Spec Sheet.
• SMILES: Not specified for this item; refer to CoA/Spec Sheet.
• InChIKey: Not specified for this item; refer to CoA/Spec Sheet.

Structural features (general guidance):

• Without a disclosed structure, ring systems, functional groups, and stereochemistry cannot be confirmed for this item. For cheminformatics registration, please request the CoA/Spec Sheet or screening set manifest.
• If included as part of a focused library, PPZ-A10 may be named by an internal code; the "PPZ" prefix sometimes denotes series association only and does not necessarily imply a piperazine or specific scaffold.

2D structure (descriptive):

• Not available for this item in the provided data. If structural data is required for assay informatics (SMILES/SDF), contact Aladdin Scientific for the associated file set under an NDA if applicable.

Synthetic Utility

PPZ-A10 is offered as a coded small molecule for screening; no structural information is provided to comment on its utility as a synthetic building block.

General notes:

• If the structure contains common handles (e.g., aryl halides, boronates, carboxylic acids, primary amines), it could, in principle, be diversified via cross-coupling, amide coupling, or alkylation. However, such possibilities are purely contingent on the actual structure.
• Without a disclosed identity, no retrosynthetic strategies or named-reaction suitability can be recommended for this specific item.
• For custom derivatization needs, contact Aladdin Scientific with your requirements; custom synthesis may be available under appropriate disclosure.

Target Specificity

No target specificity, binding partner, or selectivity profile is provided for PPZ-A10. Without structural or assay annotation, target information cannot be stated.

Guidance (general):

• Establish preliminary specificity by screening across a panel that includes off-target classes and proper negative/positive controls.
• Use orthogonal methods (e.g., enzymatic assays vs. biophysical binding) to validate hits and avoid assay artifacts.

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C. Refrigerated storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2941268-67-1, the molecular formula is C56H114N6O2, and the molecular weight is 903.54 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.