PQ-10 - 10mM in DMSO , CAS No.927691-21-2

CAS: 927691-21-2 Cat. No.: P656713 Summenformel: C₂₂H₂₁N₅O₃ Molekulargewicht: 403.43 PubChem CID: 11704101

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

PQ-10 is a potent inhibitor of Phosphodiesterase 10A ( PDE10A ) with IC 50 and ED 50 of 4.6 nM and 13 mg/kg, respectively. PQ-10 induces patterns of brain glucose metabolism which can be a potential translational biomarker. PQ-10 has the potential for researching psychiatric disorders like schizophrenia

In Vivo

PQ-10 shows region-specific increases in 2-DG uptake in the globus pallidus (equivalent to the external segment of the globus pallidus in primates) and the lateral habenula in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 24 –28 g male C57BL/6 mice, PDE10A WT and KO mice Dosage: 0.16, 0.63, 2.5, and 10 mg/kg Administration: s.c. Result: Showed region-specific increases in 2-DG uptake in the globus pallidus (equivalent to the external segment of the globus pallidus in primates) and the lateral habenula in mice.

IC50& Target:PDE10A 4.6 nM (IC 50 )

Specifications

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

PQ-10 is a potent inhibitor of Phosphodiesterase 10A ( PDE10A ) with IC 50 and ED 50 of 4.6 nM and 13 mg/kg, respectively. PQ-10 induces patterns of brain glucose metabolism which can be a potential translational biomarker. PQ-10 has the potential for res

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Namen und Kennungen

• Isomere SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)N3CCC(C3)OC4=NC5=CC=CC=C5N=C4)OC
• WGK Deutschland: 3
• PubChem CID: 11704101
• Molekulargewicht: 403.43

Referenzen

1. Aoyang Sha, Huifang Yang, Zhengyan He, Zhigao Xu, Chenjie Wu, Wu Ming, Ru'an Chi.  (2023)  Enhancement of weathered crust elution-deposited rare earth ores leaching process with the addition of PQ-10.  JOURNAL OF RARE EARTHS,      [PMID:] [10.1016/j.jre.2023.12.005]

2. Zhaojie Yang, Minghua Zhang, Yafei Xiao, Xi Zhang, Minmin Fan.  (2020)  Facile Fabrication of Poly(vinyl alcohol)/Polyquaternium-10 (PVA/PQ-10) Anion Exchange Membrane with Semi-Interpenetrating Network.  MACROMOLECULAR MATERIALS AND ENGINEERING,  306  (1): (2000506).  [PMID:] [10.1002/mame.202000506]

Häufig gestellte Fragen

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 927691-21-2, the molecular formula is C22H21N5O3, and the molecular weight is 403.43 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.