Pramipexole 2HCl Monohydrate - ≥98%(HPLC) , D2-like dopamine receptor agonist, CAS No.191217-81-9, D2-like dopamine receptor agonist

CAS: 191217-81-9 Cat. No.: P129443 Molecular Weight: 302.26 EC Number: 687-708-9 PubChem CID: 166589

GRADE & PURITY ≥98%(HPLC)

Synonyms

PRAMIPEXOLE DIHYDROCHLORIDE [USP MONOGRAPH] | SCHEMBL25118 | CCG-267486 | Mirapex (TN) | PRAMIPEXOLE HYDROCHLORIDE HYDRATE [JAN] | Pramipexole Hydrochloride Monohydrate | T72003 | UNII-3D867NP06J | D00559 | s2011 | HY-B0410A | APVQOOKHDZVJEX-QTPLPEIMSA-N

Storage

Store at 2-8°C

Shipped In

Wet ice

Overview

Pramipexole 2HCl Monohydrate is a partial/full D2S, D2L, D3, D4, receptor agonist with a Ki of 3.9, 2.2, 0.5, 5.1 nM.
A non-ergoline dopamine agonist.

Specifications

Synonyms

PRAMIPEXOLE DIHYDROCHLORIDE [USP MONOGRAPH] | SCHEMBL25118 | CCG-267486 | Mirapex (TN) | PRAMIPEXOLE HYDROCHLORIDE HYDRATE [JAN] | Pramipexole Hydrochloride Monohydrate | T72003 | UNII-3D867NP06J | D00559 | s2011 | HY-B0410A | APVQOOKHDZVJEX-QTPLPEIMSA-N

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

Pramipexole is a dopamine agonist active at D3 and D2 receptor subtypes. Pramipexole has been found to have neuroprotective effects independent of its dopamine receptor agonism. It reduces mitochondrial reactive oxygen species (ROS) production and inhibit

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

AGONIST

Mechanism of action

D2-like dopamine receptor agonist

Note

Toxic, refer to SDS for further information . Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%(HPLC)

Names and Identifiers

• Pubchem Sid: 504757593
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504757593
• Canonical Smiles: CCCNC1CCC2=C(C1)SC(=N2)N.O.Cl.Cl
• IUPAC Name: (6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine;hydrate;dihydrochloride
• InChIKey: APVQOOKHDZVJEX-QTPLPEIMSA-N
• INCHI: 1S/C10H17N3S.2ClH.H2O/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;;/h7,12H,2-6H2,1H3,(H2,11,13);2*1H;1H2/t7-;;;/m0.../s1
• Isomeric SMILES: CCCN[C@H]1CCC2=C(C1)SC(=N2)N.O.Cl.Cl
• Alternate CAS: 191217-81-9
• PubChem CID: 166589
• MeSH Entry Terms: 2 Amino 6 propylaminotetrahydrobenzothiazole;2-amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole;2-amino-6-propylaminotetrahydrobenzothiazole;4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine;6,7-tetrahydro-N6-propyl-2,6-benzothiazolediamine dihydr
• Molecular Weight: 302.26

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Class Organonitrogen compounds
      • Subclass Amines

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Class: Organonitrogen compounds
• Subclass: Amines
• Intermediate Tree Nodes: Not available
• Direct Parent: Aralkylamines
• Alternative Parents: 2-amino-1,3-thiazoles Heteroaromatic compounds Dialkylamines Azacyclic compounds Primary amines Organopnictogen compounds Organic oxides Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Aralkylamine - 1,3-thiazol-2-amine - Azole - Thiazole - Heteroaromatic compound - Secondary aliphatic amine - Secondary amine - Azacycle - Organoheterocyclic compound - Organic oxygen compound - Hydrochloride - Hydrocarbon derivative - Organic oxide - Primary amine - Organopnictogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as aralkylamines. These are alkylamines in which the alkyl group is substituted at one carbon atom by an aromatic hydrocarbyl group.
• External Descriptors: hydrate

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in water (61 mg/ml at 25 °C), DMSO (41 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).
• Specific Rotation[α]: -67° (C=1,MeOH)
• Melt Point(°C): 296-305°C
• Molecular Weight: 302.300 g/mol
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 301.078 Da
• Monoisotopic Mass: 301.078 Da
• Topological Polar Surface Area: 80.200 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 188.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 4

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