PRIMA-1 - ≥98% , CAS No.5608-24-2

CAS: 5608-24-2 Cat. No.: P287856 Molecular Weight: 185.22 EC Number: 633-494-7 PubChem CID: 322968

COA

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PRIMA-1 - ≥98% CAS No(5608-24-2) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY ≥98%

Synonyms

HMS1989H08 | SR-01000597545-3 | AKOS006292956 | HMS3676L12 | HY-19980A | CCG-38318 | RFBVBRVVOPAAFS-UHFFFAOYSA-N | A827649 | BCP26191 | NCGC00025313-01 | 2,2-Bis(hydroxymethyl)-3-quinuclidinone | 2,2bis(hydroxymethyl)-3quinuclidinone | NCI60_002297 | PRIM

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews

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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Protected from light,Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

PRIMA-1 (NSC-281668) is a mutant p53 reactivator, restores the sensitivity of TP53 mutant-type thyroid cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A

Specifications

Synonyms

HMS1989H08 | SR-01000597545-3 | AKOS006292956 | HMS3676L12 | HY-19980A | CCG-38318 | RFBVBRVVOPAAFS-UHFFFAOYSA-N | A827649 | BCP26191 | NCGC00025313-01 | 2, 2-Bis(hydroxymethyl)-3-quinuclidinone | 2, 2bis(hydroxymethyl)-3quinuclidinone | NCI60_002297 | PRIM

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Selectively restores mutant p53 activity in tumor cells via activation of Bax and PUMA. Induces apoptosis and inhibits growth of tumors with mutant p53.

Storage

Protected from light, Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

Pubchem Sid	504758472
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504758472
Canonical Smiles	C1CN2CCC1C(=O)C2(CO)CO
IUPAC Name	2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one
InChIKey	RFBVBRVVOPAAFS-UHFFFAOYSA-N
INCHI	1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2
Isomeric SMILES	C1CN2CCC1C(=O)C2(CO)CO
PubChem CID	322968
Molecular Weight	185.22

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Quinuclidines
    - Subclass Quinuclidones

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Quinuclidines
Subclass	Quinuclidones
Intermediate Tree Nodes	Not available
Direct Parent	Quinuclidones
Alternative Parents	Piperidinones Trialkylamines Ketones Azacyclic compounds Primary alcohols Organopnictogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aliphatic heteropolycyclic compounds
Substituents	Quinuclidone - Piperidinone - Piperidine - Ketone - Tertiary amine - Tertiary aliphatic amine - Azacycle - Hydrocarbon derivative - Organic oxide - Primary alcohol - Organopnictogen compound - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Carbonyl group - Amine - Alcohol - Aliphatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as quinuclidones. These are compounds containing a quinuclidine moiety which bears a ketone group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

CYP2C19 Tchem Cytochrome P450 2C19 (1 Activities)

Discover Target: CYP2C19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 (1 Activities)

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

Discover Target: CYP2D6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

Discover Target: CYP1A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

Discover Target: CYP2C9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

Discover Target: CYP2C19

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A498 (42825 Activities)

Lot Number	Certificate Type	Date	Item
K2217866	Certificate of Analysis	Sep 11, 2025	P287856
K2217865	Certificate of Analysis	Sep 11, 2025	P287856
K2217864	Certificate of Analysis	Sep 11, 2025	P287856
K2217652	Certificate of Analysis	Sep 11, 2025	P287856

Solubility	Solvent:water, Max Conc. mg/mL: 18.52, Max Conc. mM: 100
Sensitivity	Light sensitive
Molecular Weight	185.220 g/mol
XLogP3	-0.600
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	185.105 Da
Monoisotopic Mass	185.105 Da
Topological Polar Surface Area	60.800 Å²
Heavy Atom Count	13
Formal Charge	0
Complexity	217.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1