Pronethalol - Moligand™, ≥95% , Beta-2 adrenergic receptor antagonist, CAS No.54-80-8, Beta-2 adrenergic receptor antagonist

CAS: 54-80-8 Cat. No.: P337278 Summenformel: C₁₅H₁₉NO Molekulargewicht: 229.32 PubChem CID: 4930

GRADE & PURITY Moligand™, ≥95%

Synonyms

NCGC00024809-03 | 2-(isopropylamino)-1-(naphthalen-2-yl)ethanol | AKOS010125625 | Pronetalolum [INN-Latin] | UNII-XBP4RT1IMQ | AY-6204 FREE BASE | Pronetalolum | AY-6204 HCl | NETH | Q6479083 | Spectrum2_001570 | 1-(naphthalen-2-yl)-2-(propan-2-ylamino)et

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

(+/-)-Pronethalol is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. (+/-)-Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias and limits the cerebral arteriovenous malformation (AVMs)

Specifications

Synonyme

NCGC00024809-03 | 2-(isopropylamino)-1-(naphthalen-2-yl)ethanol | AKOS010125625 | Pronetalolum [INN-Latin] | UNII-XBP4RT1IMQ | AY-6204 FREE BASE | Pronetalolum | AY-6204 HCl | NETH | Q6479083 | Spectrum2_001570 | 1-(naphthalen-2-yl)-2-(propan-2-ylamino)et

Spezifikationen & Reinheit

Moligand™, ≥95%

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

ANTAGONIST

Mechanismus der Wirkung

Beta-2 adrenergic receptor antagonist

Reinheit

≥95%

Produkteigenschaften

ALogP

3

Namen und Kennungen

Kanonisches Lächeln

CC(C)NCC(C1=CC2=CC=CC=C2C=C1)O

IUPAC Name

1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol

InChIKey

HRSANNODOVBCST-UHFFFAOYSA-N

INCHI

1S/C15H19NO/c1-11(2)16-10-15(17)14-8-7-12-5-3-4-6-13(12)9-14/h3-9,11,15-17H,10H2,1-2H3

Isomere SMILES

CC(C)NCC(C1=CC2=CC=CC=C2C=C1)O

PubChem CID

4930

Molekulargewicht

229.32

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Klasse Naphthalenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Klasse: Naphthalenes
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Naphthalenes
• Alternative Parents: Aralkylamines Secondary alcohols 1,2-aminoalcohols Dialkylamines Organopnictogen compounds Hydrocarbon derivatives Aromatic alcohols
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Naphthalene - Aralkylamine - 1,2-aminoalcohol - Secondary alcohol - Secondary aliphatic amine - Secondary amine - Alcohol - Organopnictogen compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Amine - Aromatic alcohol - Hydrocarbon derivative - Aromatic homopolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as naphthalenes. These are compounds containing a naphthalene moiety, which consists of two fused benzene rings.
• External Descriptors: naphthalenes

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)

Discover Target: ADRB2

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Huh-7 (12904 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRB1 Tclin Adrenergic receptor beta (1214 Activities)

Discover Target: ADRB1

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Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

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Plasmodium falciparum (966862 Activities)

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Felis catus (3858 Activities)

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Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Molekulargewicht: 229.320 g/mol
• XLogP3: 3.000
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 229.147 Da
• Monoisotopic Mass: 229.147 Da
• Topological Polar Surface Area: 32.299 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 229.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1