QNZ (EVP4593) - Moligand™, ≥98% , CAS No.545380-34-5

CAS: 545380-34-5 Cat. No.: Q125550 Summenformel: C₂₂H₂₀N₄O Molekulargewicht: 356.42 EG-Nummer: 869-254-5 PubChem CID: 509554

GRADE & PURITY Moligand™, ≥98%

Synonyms

EVP-4593 | Curator_000005 | N~4~-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine | EVP4593 | GTPL6012 | BCP07901 | DTXSID00333507 | HMS3652J12 | AC-32085 | 4,6-Quinazolinediamine, N4-[2-(4-phenoxyphenyl)ethyl]- | QNZ(EVP4593) | AMY24212 | FT-0661997 | E

Storage

Lagerung bei -20°C, Argon geladen

Shipped In

Eistruhe + Eispads

Übersicht

QNZ (EVP4593) hemmt sowohl die NF-κB-Aktivierung als auch die TNF-α-Produktion mit einer IC50 von 11 nM bzw. 7 nM.
Ein Inhibitor des Transkriptionsfaktors NFκB.

Specifications

Synonyme

EVP-4593 | Curator_000005 | N~4~-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine | EVP4593 | GTPL6012 | BCP07901 | DTXSID00333507 | HMS3652J12 | AC-32085 | 4,6-Quinazolinediamine, N4-[2-(4-phenoxyphenyl)ethyl]- | QNZ(EVP4593) | AMY24212 | FT-0661997 | E

Spezifikationen & Reinheit

Moligand™, ≥98%

Biochemische und physiologische Mechanismen

QNZ hemmt die Aktivierung des Transkriptionsfaktors NF-κB und wurde zur Untersuchung der NF-κB-Signalübertragung verwendet. Eine fehlerhafte Aktivierung von NF-κB wird mit Krebs, Immun- und Entzündungskrankheiten und Virusinfektionen in Verbindung gebrach

Storage

Lagerung bei -20°C, Argon geladen

Verschickt in

Eistruhe + Eispads

Note

Moligand™

Hinweis

Wenn möglich, sollten Sie die Lösungen noch am selben Tag zubereiten und verwenden. Wenn Sie jedoch Stammlösungen im Voraus herstellen müssen, empfehlen wir Ihnen, die Lösung als Aliquote in dicht verschlossenen Fläschchen bei -20 °C zu lagern. Diese sind in der Regel bis zu einem Monat haltbar. Vor der Verwendung und vor dem Öffnen des Fläschchens empfehlen wir, das Produkt mindestens 1 Stunde lang auf Raumtemperatur kommen zu lassen. Benötigen Sie weitere Ratschläge zur Löslichkeit, Verwendung und Handhabung? Besuchen Sie unsere Seite mit den häufig gestellten Fragen (FAQ) für weitere Informationen.

Reinheit

≥98%

Namen und Kennungen

Pubchem Sid

504758961

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504758961

Kanonisches Lächeln

C1=CC=C(C=C1)OC2=CC=C(C=C2)CCNC3=NC=NC4=C3C=C(C=C4)N

IUPAC Name

4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine

InChIKey

IBAKVEUZKHOWNG-UHFFFAOYSA-N

INCHI

1S/C22H20N4O/c23-17-8-11-21-20(14-17)22(26-15-25-21)24-13-12-16-6-9-19(10-7-16)27-18-4-2-1-3-5-18/h1-11,14-15H,12-13,23H2,(H,24,25,26)

Isomere SMILES

C1=CC=C(C=C1)OC2=CC=C(C=C2)CCNC3=NC=NC4=C3C=C(C=C4)N

WGK Deutschland

3

PubChem CID

509554

Molekulargewicht

356.42

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Klasse Benzene and substituted derivatives
      • Subclass Diphenylethers

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Klasse: Benzene and substituted derivatives
• Subclass: Diphenylethers
• Intermediate Tree Nodes: Not available
• Direct Parent: Diphenylethers
• Alternative Parents: Quinazolinamines Diarylethers Phenoxy compounds Phenol ethers Secondary alkylarylamines Aminopyrimidines and derivatives Imidolactams Heteroaromatic compounds Azacyclic compounds Primary amines Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Diphenylether - Diaryl ether - Quinazolinamine - Diazanaphthalene - Quinazoline - Phenoxy compound - Phenol ether - Aminopyrimidine - Secondary aliphatic/aromatic amine - Imidolactam - Pyrimidine - Heteroaromatic compound - Ether - Azacycle - Organoheterocyclic compound - Secondary amine - Amine - Primary amine - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as diphenylethers. These are aromatic compounds containing two benzene rings linked to each other through an ether group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)

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EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)

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INSR Tclin Insulin receptor (5558 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDGFRB Tclin Platelet-derived growth factor receptor beta (5195 Activities)

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IGF1R Tclin Insulin-like growth factor I receptor (8605 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KIT Tclin Stem cell growth factor receptor (10667 Activities)

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DAPK3 Tchem Death-associated protein kinase 3 (2108 Activities)

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MAPK11 Tchem MAP kinase p38 beta (2785 Activities)

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LCK Tclin Tyrosine-protein kinase LCK (9212 Activities)

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MAPK14 Tchem MAP kinase p38 alpha (12866 Activities)

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GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)

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PRKCZ Tchem Protein kinase C zeta (2414 Activities)

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MAP2K6 Tchem Dual specificity mitogen-activated protein kinase kinase 6 (1284 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MYLK Tchem Myosin light chain kinase, smooth muscle (1267 Activities)

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CSNK1G1 Tchem Casein kinase I gamma 1 (2496 Activities)

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FGFR2 Tclin Fibroblast growth factor receptor 2 (3405 Activities)

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FGFR1 Tclin Fibroblast growth factor receptor 1 (9149 Activities)

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STK3 Tchem Serine/threonine-protein kinase MST2 (3069 Activities)

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CSNK1D Tchem Casein kinase I delta (4546 Activities)

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CAMK2B Tchem CaM kinase II beta (1626 Activities)

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SRC Tclin Tyrosine-protein kinase SRC (10310 Activities)

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CHEK2 Tchem Serine/threonine-protein kinase Chk2 (4015 Activities)

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PDPK1 Tchem 3-phosphoinositide dependent protein kinase-1 (3758 Activities)

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AKT2 Tchem Serine/threonine-protein kinase AKT2 (4301 Activities)

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AKT3 Tchem Serine/threonine-protein kinase AKT3 (3157 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHUK Tchem Inhibitor of nuclear factor kappa B kinase alpha subunit (3170 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IKBKB Tchem Inhibitor of nuclear factor kappa B kinase beta subunit (5554 Activities)

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DAPK2 Tchem Death-associated protein kinase 2 (740 Activities)

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AURKB Tchem Serine/threonine-protein kinase Aurora-B (6805 Activities)

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RPS6KA4 Tchem Ribosomal protein S6 kinase alpha 4 (2104 Activities)

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ROCK1 Tclin Rho-associated protein kinase 1 (4723 Activities)

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PIM1 Tchem Serine/threonine-protein kinase PIM1 (9629 Activities)

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PKN2 Tchem Protein kinase N2 (1991 Activities)

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CSK Tchem Tyrosine-protein kinase CSK (2395 Activities)

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JAK3 Tclin Tyrosine-protein kinase JAK3 (8349 Activities)

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RPS6KA5 Tchem Ribosomal protein S6 kinase alpha 5 (3355 Activities)

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PRKCE Tchem Protein kinase C epsilon (1520 Activities)

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PRKCG Tchem Protein kinase C gamma (2471 Activities)

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PRKCI Tchem Protein kinase C iota (2821 Activities)

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PRKD1 Tchem Protein kinase C mu (1904 Activities)

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RAF1 Tclin Serine/threonine-protein kinase RAF (4169 Activities)

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SYK Tclin Tyrosine-protein kinase SYK (7372 Activities)

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PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)

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ITK Tclin Tyrosine-protein kinase ITK/TSK (3699 Activities)

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RPS6KA1 Tchem Ribosomal protein S6 kinase alpha 1 (2796 Activities)

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JAK2 Tclin Tyrosine-protein kinase JAK2 (12915 Activities)

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RPS6KA6 Tchem Ribosomal protein S6 kinase alpha 6 (2027 Activities)

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CAMK1 Tchem CaM kinase I alpha (1664 Activities)

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CAMK4 Tbio CaM kinase IV (2116 Activities)

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FLT1 Tclin Vascular endothelial growth factor receptor 1 (6262 Activities)

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Prkcd Protein kinase C delta (192 Activities)

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Prkcb Protein kinase C beta (2 Activities)

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Mapk1 MAP kinase ERK2 (650 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Fgfr4 Fibroblast growth factor receptor 4 (138 Activities)

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Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)

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Camk2g CaM kinase II gamma (1 Activities)

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Tec Tyrosine-protein kinase TEC (25 Activities)

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Plasmodium falciparum (966862 Activities)

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Plasmodium berghei (192651 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Soluble in DMSO (20 mg/ml), DMF (30 mg/ml), ethanol (10 mg/ml), and 1:1 solution DMF:PBS(pH 7.2) (0.5 mg/ml).
• Empfindlichkeit: Air Sensitive,Heat Sensitive
• Schmelzpunkt (°C): 184 °C
• Molekulargewicht: 356.400 g/mol
• XLogP3: 4.700
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 356.164 Da
• Monoisotopic Mass: 356.164 Da
• Topological Polar Surface Area: 73.100 Ų
• Heavy Atom Count: 27
• Formal Charge: 0
• Complexity: 434.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1