QWF,TFA salt, CAS No.126088-82-2(free)

CAS: 126088-82-2(free) Cat. No.: Q288607 Summenformel: C₃₈H₄₃N₅O₈(free) Molekulargewicht: 697.78(free)

GRADE & PURITY Moligand™, ≥95%

Übersicht

Product description：

Tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo.
Application：

QWF is a tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo.

Specifications

Product Name

QWF,TFA salt, CAS No.126088-82-2(free)

Synonyme

N(alpha)-(N(alpha)-(N(alpha)-(tert-butyloxycarbonyl)glutaminyl)-N(1)-formyl-tryptophyl)phenylalanine | Boc-gln-trp(cho)-phe-obzl | QWF | Boc-Gln-D-Trp(CHO)-Phe-OBzl | BDBM50002533 | L-Phenylalanine, N-(N-(N2-((1,1-dimethylethoxy)carbonyl)-L-glutaminyl)-1-

Note

Moligand™

Spezifikationen & Reinheit

Moligand™, ≥95%

Biochemische und physiologische Mechanismen

Tripeptide substance P (SP) antagonist (IC50= 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cellsin vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in

Sequenz

Boc-Gln-D-Trp(Formyl)-Phe-OBzl

Aktionsart

ANTAGONIST

CAS

126088-82-2(free)

Molekültyp

Peptide

Lagerung und Versand

Storage

Store at -20°C,Argon charged

Verschickt in

Ice chest + Ice pads

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Klasse Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Ebene5 Peptides
          • Ebene6 Oligopeptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Klasse: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Peptides
• Direct Parent: Oligopeptides
• Alternative Parents: Phenylalanine and derivatives Glutamine and derivatives Alpha amino acid esters N-acyl-alpha amino acids and derivatives Tryptamines and derivatives Alpha amino acid amides Benzyloxycarbonyls Amphetamines and derivatives 3-alkylindoles Fatty acid esters N-acyl amines Substituted pyrroles Heteroaromatic compounds Carbamate esters Primary carboxylic acid amides Secondary carboxylic acid amides Carboxylic acid esters Organic carbonic acids and derivatives Monocarboxylic acids and derivatives Azacyclic compounds Carbonyl compounds Hydrocarbon derivatives Organic oxides Organonitrogen compounds Organopnictogen compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Alpha-oligopeptide - Phenylalanine or derivatives - Glutamine or derivatives - Alpha-amino acid ester - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Triptan - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - 3-alkylindole - Benzyloxycarbonyl - Amphetamine or derivatives - Indole or derivatives - Indole - Fatty acid ester - Benzenoid - N-acyl-amine - Substituted pyrrole - Fatty acyl - Monocyclic benzene moiety - Fatty amide - Carbamic acid ester - Pyrrole - Heteroaromatic compound - Carboxamide group - Carboxylic acid ester - Secondary carboxylic acid amide - Primary carboxylic acid amide - Carbonic acid derivative - Organoheterocyclic compound - Azacycle - Monocarboxylic acid or derivatives - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Organic oxide - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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Discover Target: TACR1

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Wirkungsmechanismen