Radezolid - Moligand™, ≥96% , Bacterial 70S ribosome inhibitor, CAS No.869884-78-6, Bacterial 70S ribosome inhibitor

CAS: 869884-78-6 Cat. No.: R126228 Summenformel: C₂₂H₂₃FN₆O₃ Molekulargewicht: 438.45 PubChem CID: 11224409

GRADE & PURITY Moligand™, ≥96%

Synonyms

RX-013 | rx103 | RX-103 | UNII-53PC6LO35W | MMV688327 | Radezolid | RX1741 | RX-1741 | RX-01_667 | N-[[(5S)-3-[2-Fluoro-4'-[[(1H-1,2,3-triazol-5-ylmethyl)amino]methyl][1,1'-biphenyl]-4-yl]-2-oxo-5-oxazolidinyl]methyl]acetamide

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

Radezolid (RX-1741) is a oxazolidinone antibiotic. Radezolid is active against Staphylococcus, Chlamydia, and Legionella species, and remains active against Linezolid-resistant strains.

Specifications

Synonyme

RX-013 | rx103 | RX-103 | UNII-53PC6LO35W | MMV688327 | Radezolid | RX1741 | RX-1741 | RX-01_667 | N-[[(5S)-3-[2-Fluoro-4'-[[(1H-1,2,3-triazol-5-ylmethyl)amino]methyl][1,1'-biphenyl]-4-yl]-2-oxo-5-oxazolidinyl]methyl]acetamide

Spezifikationen & Reinheit

Moligand™, ≥96%

Biochemische und physiologische Mechanismen

Radezolid (INN, codenamed RX-1741) is a novel oxazolidinone antibiotic being developed by Rib-X Pharmaceuticals, Inc. for the treatment of serious multi-drug–resistant infections. Radezolid has completed two phase-II clinical trials

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

INHIBITOR

Mechanismus der Wirkung

Bacterial 70S ribosome inhibitor

Reinheit

≥96%

Produkteigenschaften

ALogP

1.1

Namen und Kennungen

Pubchem Sid

528766922

Kanonisches Lächeln

CC(=O)NCC1CN(C(=O)O1)C2=CC(=C(C=C2)C3=CC=C(C=C3)CNCC4=NNN=C4)F

IUPAC Name

N-[[(5S)-3-[3-fluoro-4-[4-[(2H-triazol-4-ylmethylamino)methyl]phenyl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide

InChIKey

BTTNOGHPGJANSW-IBGZPJMESA-N

INCHI

1S/C22H23FN6O3/c1-14(30)25-12-19-13-29(22(31)32-19)18-6-7-20(21(23)8-18)16-4-2-15(3-5-16)9-24-10-17-11-26-28-27-17/h2-8,11,19,24H,9-10,12-13H2,1H3,(H,25,30)(H,26,27,28)/t19-/m0/s1

Isomere SMILES

CC(=O)NC[C@H]1CN(C(=O)O1)C2=CC(=C(C=C2)C3=CC=C(C=C3)CNCC4=NNN=C4)F

PubChem CID

11224409

Molekulargewicht

438.45

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Klasse Benzene and substituted derivatives
      • Subclass Biphenyls and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Klasse: Benzene and substituted derivatives
• Subclass: Biphenyls and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Biphenyls and derivatives
• Alternative Parents: Phenylmethylamines Benzylamines Aralkylamines Fluorobenzenes Aryl fluorides Oxazolidinones Triazoles Carbamate esters Heteroaromatic compounds Dialkylamines Carboximidic acids Propargyl-type 1,3-dipolar organic compounds Oxacyclic compounds Azacyclic compounds Organofluorides Carbonyl compounds Hydrocarbon derivatives Organic oxides
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Biphenyl - Benzylamine - Phenylmethylamine - Fluorobenzene - Aralkylamine - Halobenzene - Aryl fluoride - Aryl halide - Oxazolidinone - Azole - Heteroaromatic compound - Oxazolidine - Carbamic acid ester - 1,2,3-triazole - Oxacycle - Carboximidic acid - Carboximidic acid derivative - Secondary aliphatic amine - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Secondary amine - Organic oxygen compound - Organic nitrogen compound - Organic oxide - Hydrocarbon derivative - Organohalogen compound - Organofluoride - Organonitrogen compound - Organooxygen compound - Amine - Carbonyl group - Aromatic heteromonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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THP-1 (11052 Activities)

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HUVEC (11049 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Streptococcus (3973 Activities)

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Streptococcus pneumoniae (31063 Activities)

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Enterococcus (1748 Activities)

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Chlamydia pneumoniae (241 Activities)

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Legionella pneumophila (143 Activities)

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Staphylococcus aureus (210822 Activities)

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Staphylococcus epidermidis (22802 Activities)

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Staphylococcus hominis (482 Activities)

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Moraxella catarrhalis (3334 Activities)

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Haemophilus influenzae (8812 Activities)

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Chlamydia trachomatis (699 Activities)

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Staphylococcus (1598 Activities)

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Streptococcus pyogenes (16140 Activities)

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Enterococcus faecium (13803 Activities)

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Listeria monocytogenes (2626 Activities)

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Mycoplasmoides pneumoniae (351 Activities)

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Enterococcus faecalis (29875 Activities)

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Staphylococcus capitis (242 Activities)

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J774 (3120 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Metamycoplasma hominis (88 Activities)

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Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO
• Molekulargewicht: 438.500 g/mol
• XLogP3: 1.100
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 8
• Exact Mass: 438.182 Da
• Monoisotopic Mass: 438.182 Da
• Topological Polar Surface Area: 112.000 Ų
• Heavy Atom Count: 32
• Formal Charge: 0
• Complexity: 647.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1