10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 7 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Ranitidine (AH19065) is ahistamine H2-receptorantagonist, used to treat stomach or intestinal ulcers.
In vitro
Ranitidine sensitizes hepatocytes to killing by cytotoxic products from activated neutrophils, whereas Famotidine lacks this ability. Ranitidine inhibits the production of tumor necrosis factor-alpha (TNF-alpha) in monocytes stimulated with lipopolysaccharide in vitro. Ranitidine reduces the Kel of morphine dose-dependently with a maximum effect of 50%, and increases the relative concentration of morphine-6-glucuronide to morphine-3-glucuronide in isolated guinea pig hepatocytes. Ranitidine gradually decreases the morphine-3-glucuronide/morphine-6-glucuronide ratio by up to 21%.
In vivo
Ranitidine results in liver injury as evidence by increased in serum alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase activities within 6 hours after Ranitidine administration in rats. Ranitidine inhibits hepatic ischemia/reperfusion-induced increase in hepatic tissue levels of TNF-alpha, cytokine-induced neutrophil chemoattractant, and hepatic accumulation of neutrophils in rats. Ranitidine cotreatment enhances LPS-induced coagulation prior to liver injury, and anticoagulants reduce liver damage in LPS/RAN-treated rats. Ranitidine /LPS-treated rats results in the formation of fibrin clots in liver sinusoids, and prevention of fibrin deposition associated with reduced hepatocellular injury. Ranitidine cotreatment enhances the LPS-induced TNF increase before the onset of hepatocellular injury in rats. Ranitidine displays anxiolytic effects in the elevated plus-maze as indicated by an increase in time spent in the open arms, more open-arm scanning and more end-excursions in rats.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥100%
| Isomere SMILES | CN/C(=C\[N+](=O)[O-])/NCCSCC1=CC=C(O1)CN(C)C.Cl |
|---|---|
| WGK Deutschland | 2 |
| RTECS | KM6557000 |
| Molekulargewicht | 350.86 |
| Reaxy-Rn | 5196014 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5196014&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Löslichkeit | Solubility (25°C) In vitro Water: 55 mg/mL (198.37 mM); DMSO: 4 mg/mL (14.42 mM); |
|---|---|
| Schmelzpunkt (°C) | 135 °C(dec.) |
| 1. Zhizhuo Chai, Jingquan Wang, Yixue Dai, Erdeng Du, Hongguang Guo. (2023) Synergy between UV light and trichloroisocyanuric acid on methylisothiazolinone degradation: Performance, kinetics and degradation pathway.. ENVIRONMENTAL RESEARCH, [PMID:37481058] [10.1016/j.envres.2023.116693] |
| 2. Tao Long, Weiwei Tan, Xiangmin Tian, Zongjian Tang, Keming Hu, Liming Ge, Changdao Mu, Xinying Li, Yongbin Xu, Lei Zhao, Defu Li. (2022) Gelatin/alginate-based microspheres with sphere-in-capsule structure for spatiotemporal manipulative drug release in gastrointestinal tract. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:36521695] [10.1016/j.ijbiomac.2022.12.040] |
| 3. Yangke Long, Jian Dai, Shiyin Zhao, Yiping Su, Zhongying Wang, Zuotai Zhang. (2021) Atomically Dispersed Cobalt Sites on Graphene as Efficient Periodate Activators for Selective Organic Pollutant Degradation. ENVIRONMENTAL SCIENCE & TECHNOLOGY, [PMID:33729757] [10.1021/acs.est.0c07794] |
| 4. Fengyi Du, Yunchao Wu, Fengting Du, Lirong Zhang, Weiwei Feng, Lulu Zhao, Rong Cai, Lixia Xu, Gaorui Bian, Jiangang Li, Shengqiang Zou, Aihua Gong, Miaomiao Zhang. (2019) Construction of catechol-grafted chitosan alginate/barium sulfate microcapsules for computed tomography real-time imaging and gastroretentive drug delivery. International Journal of Nanomedicine, [PMID:31447554] [10.2147/IJN.S204237] |
| 5. Yaqiong Guo, Yingying Xie, Jianhua Qin. (2024) A generic pump-free organ-on-a-chip platform for assessment of intestinal drug absorption. Biotechnology Journal, 19 (2): (2300390). [PMID:38375564] [10.1002/biot.202300390] |
| 6. Zhang Mei, Zhao Jingwen, Long Yingying, Li Changsong, Yang Xiaoming. (2024) Carbon Dots Employed for the Detection of Ranitidine and Elaborating the Detecting Mechanism. JOURNAL OF FLUORESCENCE, [PMID:39269550] [10.1007/s10895-024-03912-5] |
| 7. Yichong Wang, Danyan Li, Luqing Zhao, Jixiang Liu, Dan Dou, Nian Liu, Yudi Zhuo, Shengsheng Zhang. (2025) Mechanism of Yinxu Weitong Capsule in the treatment of precancerous lesions of gastric cancer based on network pharmacology and experimental validation. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:39761837] [10.1016/j.jep.2024.119303] |
