RB-3 - ≥99% , CAS No.2396639-11-3

CAS: 2396639-11-3 Cat. No.: R647132 Summenformel: C₂₄H₂₀ClN₃O₂ Molekulargewicht: 417.89

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Übersicht

RB-3, a PRC1 inhibitor, binds to RING1B-BMI1f , with a K d of 2.8 μM

In Vitro

RB-3 decreases the global level of H2A ubiquitination and induces differentiation in leukemia cell lines and primary acute myeloid leukemia (AML) samples. RB-3 inhibits H2A ubiquitination with an IC 50 of 1.6 μM. RB-3 inhibits PRC1 and disrupts the interaction with nucleosomes. RB-3 reduces colony formation in a mixed lineage leukemia (MLL)-eleven nineteen leukemia (ENL) model. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: TEX cells. Concentration: 6, 12, 25 μM. Incubation Time: 8d. Result: Dose-dependently increased C/EBPα-p42 protein levels.

Form:Solid

IC50& Target:Kd: 2.8 μM (RING1B-BMI1f)

Specifications

Spezifikationen & Reinheit

≥99%

Biochemische und physiologische Mechanismen

RB-3, a PRC1 inhibitor, binds to RING1B-BMI1f , with a K d of 2.8 μM.

Storage

Store at 2-8°C,Protected from light,Desiccated

Verschickt in

Wet ice

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Reinheit

≥99%

Namen und Kennungen

• Kanonisches Lächeln: O=C(C1=C(C2=C3C=CNC3=CC=C2Cl)C(C(C)C)=C(C4=C5C=CNC5=CC=C4)N1)O
• Molekulargewicht: 417.89

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO : 100 mg/mL (239.30 mM; Need ultrasonic)

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, protected from light, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2396639-11-3, the molecular formula is C24H20ClN3O2, and the molecular weight is 417.89 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.