Re 80 , CAS No.116193-60-3

CAS: 116193-60-3 Cat. No.: R1454217 Summenformel: C₂₄H₂₆O₅ Molekulargewicht: 394.46

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

Re 80 is an anti-angiogenic agent and is a synthetic retinoid.

Specifications

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Namen und Kennungen

• Molekulargewicht: 394.46

Application Protocols

No tested applications or protocols are supplied in the current listing.

• Item-specific protocol guidance

  • Not specified for this item; refer to CoA/Spec Sheet.

• General protocol scaffolds (to adapt once identity is confirmed)

  • Preparation of stock solutions: Determine solvent system (water, buffer, DMSO). Prepare at a convenient concentration (e.g., 10–100 mM for small molecules; mg/mL for macromolecules). Filter if sterility is required and compatible.
  • Handling frozen materials (−20°C): Thaw on ice or at 2–8°C. Mix gently to avoid foaming. Aliquot to single-use vials to minimize freeze–thaw cycles.
  • Stability check: Analyze an aliquot by LC–UV/LC–MS after preparation and after defined storage intervals to confirm integrity.

• Documentation

  • Record batch/lot, preparation date, solvent/buffer composition, pH (if aqueous), and storage conditions. Attach chromatograms/spectra to your ELN for traceability.

Biological Roles

Item-specific biological function and target relationships are not disclosed in the current listing.

• Item-specific details

  • Biological role/target/pathway: Not specified for this item; refer to CoA/Spec Sheet.

• General guidance for evaluating biological roles

  • Confirm identity and purity prior to mechanistic or phenotypic studies (e.g., LC–MS, NMR, HPLC/UPLC area %). Trace impurities can confound bioassay readouts.
  • Establish a concentration–response relationship with appropriate vehicle controls to exclude nonspecific effects (e.g., solvent toxicity, surfactant artifacts).
  • Assess stability in relevant biological matrices (serum, culture media, lysate) and buffers; perform recovery studies to detect adsorption or degradation.
  • If fluorescent/UV-active, check for spectral overlap with assay probes to avoid false positives/negatives.
  • Consider off-target profiling (if a small molecule) using panel assays or thermal shift methods as appropriate.

• Documentation

  • Keep detailed records of batch number, storage history (−20°C), and number of freeze–thaw cycles to correlate with biological outcomes.

This section will be updated with specific pathways or enzymatic roles when the product’s structure and intended use are defined by the CoA/TDS.

Buffer Applications

No buffer-specific information is provided for this item.

• Item-specific buffer use

  • Not specified for this item; refer to CoA/Spec Sheet.

• General notes

  • If this reagent is intended as a buffer component or additive (salt, acid/base pair, osmolyte), determine: pKa values, buffering range, ionic strength contribution, compatibility with divalent cations, temperature coefficient (dpKa/dT), and UV absorbance at analytical wavelengths.
  • Filter sterilization (0.22 µm) and depyrogenation steps should be validated if the buffer is for cell culture or sensitive enzymology.
  • Verify stability at storage temperature (−20°C) and assess precipitation upon thawing; some salts and zwitterions can crystallize during freezing.

• Practical tip

  • Prepare small test formulations at intended pH and ionic strength, then monitor clarity, pH drift, and activity of your system over time.

Green Alternatives

With the product identity not disclosed in this listing, green assessment must be tailored after structure and use-case are confirmed. The following framework helps determine greener choices:

• Assessment framework (general)

  • Map the life-cycle: sourcing (bio-based vs petrochemical), synthesis steps (E-factor, PMI), solvents and reagents used, energy intensity (−20°C storage), packaging, and end-of-life.
  • Identify hotspots: toxic solvents, halogenated reagents, heavy metals, and cold-chain logistics.

• Potential greener substitutions (depends on identity/use)

  • Solvents: Replace chlorinated solvents with ethyl acetate, 2-MeTHF, CPME, or water where scientifically feasible.
  • Buffers: Prefer Good’s buffers with low metal-binding and low toxicity; avoid phosphate where precipitation or eutrophication is a concern.
  • Stabilizers/preservatives: Choose less hazardous antioxidants or radical scavengers when compatible with target assays.

• Process improvements

  • Concentrate shipping to reduce cold-chain volume; use validated room-temperature-stable formulations if the reagent allows.
  • Implement microscale screening to reduce material consumption and waste.

• Trade-offs

  • Greener options may reduce performance or stability; all substitutions should be supported by side-by-side analytical and functional comparisons (activity, purity, stability profiles).

Note: A product-specific green profile can be prepared upon receipt of the CoA/SDS and intended application details.

Pharmaceutical Uses

No pharmacopeial status or excipient role is stated for this product; it is supplied strictly for research use only.

• Item-specific status

  • Regulatory/compendial listings (USP/EP/JP): Not specified for this item; refer to CoA/Spec Sheet.
  • Excipient or processing aid role: Not specified for this item.

• General considerations (formulation R&D context)

  • If explored as an excipient or additive in preclinical research, assess: solubility enhancement, stabilization of APIs (e.g., as antioxidant, chelator, osmoprotectant), isotonicity effects, and compatibility with dosage forms (parenteral vs oral vs topical).
  • Evaluate extractables/leachables from contact materials, and endotoxin/bioburden if used in biologics research.
  • Confirm absence of residual solvents and control impurities per ICH Q3A/B guidance for research-stage materials.

• Important note

  • Aladdin Scientific products are for laboratory research use only and are not intended for human or veterinary use, diagnostic procedures, or clinical applications.

Physical Properties

Item-specific physical constants are not disclosed in the current listing; consult CoA/SDS for definitive values.

• Item-specific (from Product Data)

  • Appearance: Not specified for this item; refer to CoA/Spec Sheet.
  • Molecular Weight: Not specified for this item; refer to CoA/Spec Sheet.
  • Storage Conditions: Store at −20°C (provided).
  • Shipping: Ice chest + ice pads (provided).

• Typical properties to request for qualification (general guidance)

  • Melting/Freezing point, Boiling point, Density: Not specified for this item; refer to CoA/Spec Sheet.
  • Solubility profile: Not specified for this item; request data by solvent (water, PBS, DMSO, methanol, ethanol, acetonitrile) and temperature.
  • pKa/logP/logD, refractive index (if liquid): Not specified for this item; refer to CoA/Spec Sheet.
  • UV–Vis characteristics (ε, λmax) for quantitation: Not specified for this item; refer to CoA/Spec Sheet.

• Practical notes (general laboratory guidance)

  • For solids of uncertain hygroscopicity, handle quickly at ambient and recap with desiccant; allow vial to warm in a desiccator before opening to minimize moisture condensation when stored at −20°C.
  • For liquids or viscous materials, pre-cool pipette tips if volatility is suspected; verify miscibility in intended assay buffers or organic solvents on a small scale.
  • If the reagent is used by mass, establish a working density empirically if supplied as a liquid without a stated density.

Quality and Grades

• Item-specific grade/purity (from Product Data)

  • Grade/Purity: Not specified for this item; refer to CoA/Spec Sheet.

• Guidance on interpreting grade (general)

  • For life-science reagents, typical quality designations include: research grade, molecular biology grade (DNase/RNase-free), cell culture grade (low endotoxin), HPLC grade (for solvents), analytical grade, or reference standard grade. The absence of a stated grade means the product should be treated as research-use only and qualified for your intended application.
  • If low absorbance (UV-cutoff) or low trace metal content is important (e.g., LC–MS workflows, catalysis-sensitive assays), request batch-specific impurity profiles.

• Purity determination (general)

  • Purity may be reported by HPLC/UPLC area %, NMR qNMR, GC, or titration depending on the analyte class. Confirm the method on the CoA to ensure compatibility with your application.

• Stabilizers/additives

  • If the material requires stabilizers, quenchers, or preservatives, these will be listed on the CoA/SDS. Absence of such disclosure here does not imply they are absent.

• Recommendations

  • Request CoA for: assay purity, residual solvents, water (KF), bioburden/endotoxin (if biologically relevant), and identity confirmation (NMR/MS). Qualify a small aliquot in your assay before scale-up.

Reaction and Applications

The product is categorized under life sciences; no specific chemical reactivity or application notes are provided in the listing.

• Item-specific applications (from Product Data)

  • Manufacturer Applications: Not specified in this listing.
  • Research Use Note: For research use only.

• General application contexts (if applicable to your identity confirmation)

  • If the reagent is a small molecule tool compound: may be used in target engagement studies, biochemical assays, or probe development following proper qualification.
  • If the reagent is a biopolymer, peptide, or oligonucleotide: applications would include enzymology, binding studies, or molecular biology workflows subject to purity/sequence confirmation.
  • If the reagent is an excipient/additive: applications might include stabilization of proteins, control of ionic strength/osmolality, or modulation of buffer properties.

• Practical tips (general)

  • Qualify stability under assay conditions (temperature, light, pH, oxidative milieu). Run a time-course stability check by LC/UV or LC–MS.
  • If solutions are prepared, document solvent, concentration, and storage time; avoid multiple freeze–thaw cycles by aliquoting.
  • Validate absence of assay interference (fluorescence quenching, absorbance overlap, detergent effects) with appropriate controls.

Reaction Conditions

No reaction condition guidance can be provided without the reagent’s identity and role.

• Item-specific data

  • Not specified for this item; refer to CoA/Spec Sheet.

• General best practices

  • If the reagent is moisture/air sensitive, handle under inert atmosphere (N2/Ar) and use anhydrous solvents; confirm by SDS/CoA.
  • Define temperature limits experimentally starting from ambient; avoid exceeding 50–60°C until stability is verified.
  • For solution use, establish concentration windows and solvent composition by small-scale solubility/stability screens.
  • Monitor reactions by TLC, HPLC, or LC–MS with appropriate internal standards.

• Documentation

  • Record batch number, exact mass/volume, solvent lot, and environmental conditions. Maintain traceability for reproducibility.

Safety and Handling

Safety details are not provided in the listing. Always consult the batch-specific SDS for authoritative information.

• Item-specific hazard data (from Product Data)

  • GHS Classification: Not specified for this item; refer to SDS.
  • Signal Word: Not specified for this item; refer to SDS.
  • H-Statements: Not specified for this item; refer to SDS.
  • Pictograms: Not specified for this item; refer to SDS.

• General laboratory precautions (applicable to unknown life-science reagents)

  • Use in a chemical fume hood or biosafety cabinet as appropriate to your risk assessment.
  • Wear suitable PPE: lab coat, safety glasses, and gloves (nitrile recommended unless chemical incompatibility dictates otherwise).
  • Avoid inhalation, ingestion, and skin/eye contact; prevent aerosol generation when weighing or reconstituting.
  • Keep away from incompatible materials until compatibility is confirmed (strong oxidizers/reducers, strong acids/bases, and reactive metals are common concerns; verify via SDS).

• First aid overview (general)

  • Skin/eye contact: Rinse with water for at least 15 minutes; remove contaminated clothing; seek medical attention per SDS guidance.
  • Inhalation: Move to fresh air; provide oxygen if trained and necessary; seek medical attention.
  • Ingestion: Rinse mouth; do not induce vomiting unless directed by medical personnel; seek medical attention.

• Special risks

  • Unknown peroxide or dust explosion hazards; assess based on identity once SDS is available.
  • For materials stored at −20°C, avoid thermal shock; allow controlled warming in secondary containment before opening.

Solvent Selection

Item-specific solvent preferences and solubility are not provided in the listing.

• What to verify for this item (request or test)

  • Aqueous solubility across pH 2–9 (buffered) and ionic strength sensitivity.
  • Organic solubility in DMSO, methanol, ethanol, acetonitrile, isopropanol, acetone, ethyl acetate, toluene, and DMF (as relevant).
  • Compatibility with common biological buffers (PBS, Tris, HEPES) and presence of any precipitation with salts or divalent cations.

• Practical decision framework (general)

  • Biological assays/cell work: Prefer aqueous buffers; use minimal DMSO as cosolvent (≤0.1–1% v/v typical) to avoid cell stress.
  • Analytical prep (HPLC/LC–MS): Choose solvents that match method requirements (water–acetonitrile or water–methanol gradients). Ensure analyte stability in mobile phases (pH and oxidative conditions).
  • Stock solutions: If identity permits, DMSO stocks at 10–100 mM are common for small molecules; filter-sterilize (0.22 µm) if sterility is required and the compound is filter-stable.

• Notes

  • Without structure, dielectric constant, polarity index, and partition data are unknown. Conduct a small solubility screen and record outcomes for method files.

Storage and Reconstitution

• Item-specific storage (from Product Data)

  • Recommended Storage: Store at −20°C.
  • Shipping Condition: Ice chest + ice pads.

• Additional storage guidance (general)

  • Keep container tightly closed. If moisture/air sensitivity is suspected, store under inert atmosphere or with desiccant. Protect from light until photostability is known.
  • For long-term storage, minimize freeze–thaw cycles by preparing single-use aliquots. Record the number of freeze–thaw events for each aliquot.
  • Allow vials to equilibrate to room temperature in a desiccator before opening to prevent condensation when removed from −20°C.

• Reconstitution (item-specific)

  • Solvent/Buffer: Not specified for this item; refer to CoA/Spec Sheet.
  • Concentration: Not specified for this item; refer to CoA/Spec Sheet.
  • pH/Excipient requirements: Not specified for this item; refer to CoA/Spec Sheet.

• Practical tips (general)

  • Start with small-scale reconstitution trials to identify a stable solvent/buffer system. If using DMSO stocks for small molecules, dilute into assay buffer slowly with vigorous mixing to prevent precipitation.
  • If sterility is required, 0.22 µm filtration can be used for compatible solutions; avoid filter materials that adsorb the compound.
  • Label aliquots with concentration, solvent, date, and operator. Store according to stability data and discard upon signs of degradation (precipitation, discoloration, off-odor) or beyond validated hold times.

• Research use

  • For research use only; not for human or veterinary use.

Structure and Identity

Brief description: This product is listed as a life-science reagent with limited structural disclosure in the current catalog entry.

• Item-specific identifiers

  • SKU: R1454217
  • Product Name: Re 80
  • CAS: 116193-60-3 (item listing)
  • Molecular Formula: Not specified for this item; refer to CoA/Spec Sheet.
  • Molecular Weight: Not specified for this item; refer to CoA/Spec Sheet.
  • SMILES: Not specified for this item; refer to CoA/Spec Sheet.
  • InChIKey: Not specified for this item; refer to CoA/Spec Sheet.

• Structural features (general guidance)

  • Item-specific functional groups, ring systems, and stereochemistry are not disclosed in the provided data. Please consult the product CoA, technical data sheet (TDS), or SDS for definitive identity attributes.
  • If you are qualifying this material for method development or bioassay use, we recommend obtaining a current batch CoA that includes structural confirmation (e.g., NMR, MS, HPLC/UPLC purity) where applicable.

• 2D-structure description

  • Not provided in the current listing. If structural data are needed for cheminformatics workflows (SMILES/InChI), contact Aladdin Scientific Customer Support with the SKU and desired format.

Notes

• The CAS number is provided but no other identifiers are supplied in this listing. Cross-verification against authoritative databases should be performed using the batch-specific CoA.

Synthetic Utility

The product is listed under life sciences with no disclosed functional groups or reactivity; synthetic applications cannot be detailed without identity.

• Item-specific synthetic features

  • Functional groups/reactivity: Not specified for this item; refer to CoA/Spec Sheet.

• General guidance (if used as a small-molecule intermediate or reagent)

  • Confirm chemical stability under planned transformations (acid/base, redox, heat, light) by small-scale tests.
  • Establish protective group strategies if relevant; assess compatibility with common reagents (carbodiimides, coupling agents, bases, oxidants/reductants).
  • Track residual water and volatile content for moisture-sensitive reactions; consider Karl Fischer and headspace GC when needed.

• Analytical control

  • Use orthogonal identity checks (NMR, MS, IR) and purity assays (HPLC/GC). Maintain in-process controls if the reagent is incorporated into multistep sequences.

If your application requires specific reactivity, please provide the CoA/TDS so we can advise on optimal synthetic workflows.

Target Specificity

This section applies primarily to biologics (antibodies, proteins) or target-validated small molecules. For this product, no target specificity data are provided.

• Item-specific details (from Product Data)
  • Antigen/target name: Not provided.
  • Clone/isotype/species reactivity: Not provided.
  • Epitope mapping/affinity: Not provided.

If the product is intended as a target-directed probe, please consult the batch CoA/TDS or contact technical support with the SKU for detailed specificity information.