RepSox (E-616452) - 10mM in DMSO , CAS No.446859-33-2

CAS: 446859-33-2 Cat. No.: R408431 Summenformel: C₁₇H₁₃N₅ Molekulargewicht: 287.32 EG-Nummer: 663-924-9

GRADE & PURITY 10mM in DMSO

Synonyms

SJN 2511,ALK5 Inhibitor II | 1,5-Naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

RepSox (E-616452, SJN 2511, ALK5 Inhibitor II) is a potent and selective inhibitor of theTGFβR-1/ALK5withIC50of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation in cell-free assays, respectively.
In vitro

RepSox inhibits ATP binding to ALK5 and ALK5 autophosphorylation with IC50 of 23 nM and 4 nM, respectively. RepSox inhibits TGF-β induced cellular PAI-1 luciferase activity with IC50 of 18 nM. RepSox is able to successfully replace Sox2 in reprogramming by inhibiting transforming growth factor-β (Tgf-β) signaling, which in turn induces Nanog expression. Effect of RepSox inducing reprogramming does not require chromatin remodeling. RepSox is found to be efficient at generating iPSCs.

In vivo

RepSox is able to be contribute to forming chimeric embryos in vivo when injected into blastocysts. A one-day treatment with RepSox is sufficient to replace transgenic Sox2.
Cell Data

cell lines：MCF-7 cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyme

SJN 2511,ALK5 Inhibitor II | 1,5-Naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

RepSox (E-616452, SJN 2511, ALK5 Inhibitor II) is a potent and selective inhibitor of the TGFβR-1/ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation in cell-free assays, respectively.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Namen und Kennungen

• Isomere SMILES: CC1=NC(=CC=C1)C2=C(C=NN2)C3=NC4=C(C=C3)N=CC=C4
• WGK Deutschland: 3
• Molekulargewicht: 287.32

Zugehörige Ziele (menschlich)

TGFBR1 Tchem TGF-beta receptor type-1 (4 Activities)

Discover Target: TGFBR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro DMSO: 47 mg/mL (198.09 mM); Ethanol: 21 mg/mL (88.51 mM); Water: Insoluble
• Schmelzpunkt (°C): 195 °C