RG108 - 10mM in DMSO , CAS No.48208-26-0

CAS: 48208-26-0 Cat. No.: R408948 Summenformel: C₁₉H₁₄N₂O₄ Molekulargewicht: 334.33 PubChem CID: 702558

QUALITÄT & REINHEIT 10mM in DMSO

Synonyms

N-Phthalyl-L-tryptophan | 1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, (αS)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

RG108 RG108 (N-Phthalyl-L-tryptophan) is an inhibitor of DNA methyltransferase with IC50 of 115 nM in a cell-free assay, does not cause trapping of covalent enzymes.
In vitro

RG108 effectively blocks DNA methyltransferases in vitro and does not cause covalent enzyme trapping in human cell lines. Incubation of cells with low micromolar concentrations of RG108 results in significant demethylation of genomic DNA without any detectable toxicity. Intriguingly, RG108 causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences. In another study, the synthesis and in vitro analysis of a biotinylated RG108 conjugate is investigated to evaluate the interactions with DNA methyltransferase enzymes. In a recent study, it is shown RG108 can significantly reduce the DNA methyltransferases activity in SM derived iPS cells as compared to the native SMs.

In vivo

Cell Data

cell lines：

Concentrations：1-100 μM

Incubation Time：5 days

Powder Purity:≥99%

Spezifikationen

Synonyme

N-Phthalyl-L-tryptophan | 1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, (αS)-

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

RG108 (N-Phthalyl-L-tryptophan) is an inhibitor of DNA methyltransferase with IC50 of 115 nM in a cell-free assay, does not cause trapping of covalent enzymes.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Namen und Kennungen

Isomere SMILES

C1=CC=C2C(=C1)C(=O)N(C2=O)[C@@H](CC3=CNC4=CC=CC=C43)C(=O)O

WGK Deutschland

3

PubChem CID

702558

Molekulargewicht

334.33

Reaxy-Rn

4552782

Zugehörige Ziele (menschlich)

DNMT3B Tchem DNA (cytosine-5)-methyltransferase 3B (1 Activities)

Discover Target: DNMT3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DNMT1 Tclin DNA (cytosine-5)-methyltransferase 1 (1 Activities)

Discover Target: DNMT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemische und physikalische Eigenschaften

• Spezifische Drehung [α]: -271° (C=1,EtOH)
• Schmelzpunkt (°C): 181 °C

Häufig gestellte Fragen

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 48208-26-0, the molecular formula is C19H14N2O4, and the molecular weight is 334.33 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.