Ro 67-4853 - Moligand™,≥98% , Allosteric modulator of mGlu 1 receptor, CAS No.302841-89-0, Allosteric modulator of mGlu 1 receptor

CAS: 302841-89-0 Cat. No.: R276214 Summenformel: C₁₉H₁₉NO₄ Molekulargewicht: 325.36 EG-Nummer: 109-903-5 PubChem CID: 9949202

GRADE & PURITY Moligand™, ≥98%

Synonyms

Carbamic acid, (9H-xanthen-9-ylcarbonyl)-, butyl ester | RQBUXEUMZZQUFY-UHFFFAOYSA-N | butyl 9H-xanthene-9-carbonylcarbamate | NCGC00370922-01 | QM27L9Q3RZ | SCHEMBL3727778 | AKOS024458108 | Butyl N-(9H-xanthen-9-ylcarbonyl)carbamate | FT-0674449 | (9H-xa

Storage

Protected from light,Store at -20°C,Argon charged,Desiccated

Shipped In

Ice chest + Ice pads

Specifications

Synonyme

Carbamic acid, (9H-xanthen-9-ylcarbonyl)-, butyl ester | RQBUXEUMZZQUFY-UHFFFAOYSA-N | butyl 9H-xanthene-9-carbonylcarbamate | NCGC00370922-01 | QM27L9Q3RZ | SCHEMBL3727778 | AKOS024458108 | Butyl N-(9H-xanthen-9-ylcarbonyl)carbamate | FT-0674449 | (9H-xa

Spezifikationen & Reinheit

Moligand™, ≥98%

Biochemische und physiologische Mechanismen

Ro 67-4853 is a positive allosteric modulator (PAM) of mGluR1 (pEC50=7.16 for rmGlu1a receptor). Ro67-4853 exhibits activity at all group I mGlu receptors including hmGlu1, rmGlu1, and rmGlu5. Ro 67-4853 enhances the potency of L-Glu by interacting with t

Storage

Protected from light,Store at -20°C,Argon charged,Desiccated

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

ALLOSTERIC MODULATOR

Mechanismus der Wirkung

Allosteric modulator of mGlu 1 receptor

Hinweis

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Reinheit

≥98%

Namen und Kennungen

• Kanonisches Lächeln: CCCCOC(=O)NC(=O)C1C2=CC=CC=C2OC3=CC=CC=C13
• IUPAC Name: butyl N-(9H-xanthene-9-carbonyl)carbamate
• InChIKey: RQBUXEUMZZQUFY-UHFFFAOYSA-N
• INCHI: 1S/C19H19NO4/c1-2-3-12-23-19(22)20-18(21)17-13-8-4-6-10-15(13)24-16-11-7-5-9-14(16)17/h4-11,17H,2-3,12H2,1H3,(H,20,21,22)
• Isomere SMILES: CCCCOC(=O)NC(=O)C1C2=CC=CC=C2OC3=CC=CC=C13
• Alternative CAS-Nummer: 302841-89-0
• PubChem CID: 9949202
• MeSH-Eintrag: (9H-xanthene-9-carbonyl)carbamic acid butyl ester;Ro 67-4853;Ro67-4853
• Molekulargewicht: 325.36

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Klasse Benzopyrans
      • Subclass 1-benzopyrans
        • Ebene5 Dibenzopyrans
          • Ebene6 Xanthenes

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Klasse: Benzopyrans
• Subclass: 1-benzopyrans
• Intermediate Tree Nodes: Dibenzopyrans
• Direct Parent: Xanthenes
• Alternative Parents: Diarylethers Benzenoids Dicarboximides Carbamate esters Oxacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Xanthene - Diaryl ether - Benzenoid - Dicarboximide - Carbamic acid ester - Ether - Carboxylic acid derivative - Oxacycle - Organic oxide - Organic oxygen compound - Carbonyl group - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as xanthenes. These are polycyclic aromatic compounds containing a xanthene moiety, which consists of two benzene rings joined to each other by a pyran ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

GRM1 Tchem Metabotropic glutamate receptor 1 (1 Activities)

Discover Target: GRM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemische und physikalische Eigenschaften

• Löslichkeit: Soluble in DMSO to 100 mM
• Empfindlichkeit: Moisture sensitive；Light sensitive
• Molekulargewicht: 325.400 g/mol
• XLogP3: 3.400
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 325.131 Da
• Monoisotopic Mass: 325.131 Da
• Topological Polar Surface Area: 64.599 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 431.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C, protected from light, desiccated, under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 302841-89-0, the molecular formula is C19H19NO4, and the molecular weight is 325.36 g/mol. InChIKey RQBUXEUMZZQUFY-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.