ROC-0929 - ≥99% , CAS No.1048660-43-0

CAS: 1048660-43-0 Cat. No.: R646330 Molecular Weight: 561.65

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A 2 (sPLA 2 s) with an IC 50 of 80 nM, specially targeting hGX . ROC-0929 inhibits the phosphorylation of ERK1/2 and p-38 . Secreted phospholipases A2 (sPLA2s) are a family of disulfide-rich, Ca 2+ -dependent enzymes that hydrolyze the sn-2 position of glycero-phospholipids to release a fatty acid and a lysophospholipid. ROC-0929 has the potential for researching inflammation related diseases

Form:Solid

IC50& Target:80 nM (hGX)

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A 2 (sPLA 2 s) with an IC 50 of 80 nM, specially targeting hGX . ROC-0929 inhibits the phosphorylation of ERK1/2 and p-38 . Secreted phospholipases A2 (sPLA2s) are a fa

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Canonical Smiles: O=C(C(N)=O)C1=C(CC(C)C)N(CC2=CC=CC=C2)C3=CC=CC(OC(C)C(NS(=O)(C4=CC=CC=C4)=O)=O)=C31
• Molecular Weight: 561.65

Chemical and Physical Properties

• Solubility: DMSO : 12.5 mg/mL (22.26 mM; ultrasonic and warming and heat to 60°C)