Roxadustat (FG-4592) - Moligand™, 10mM in DMSO , Hypoxia-inducible factor prolyl hydroxylase inhibitor, CAS No.808118-40-3, Hypoxia-inducible factor prolyl hydroxylase inhibitor

CAS: 808118-40-3 Cat. No.: R408843 Summenformel: C₁₉H₁₆N₂O₅ Molekulargewicht: 352.34 EG-Nummer: 813-400-2

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

ASP1517 | 2-(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxamido)acetic acid

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

Roxadustat (FG-4592) Roxadustat (FG-4592) is an HIF-α prolyl hydroxylase inhibitor in a cell-free assay, stabilizes HIF-2 and induces EPO production. Roxadustat potentiates RSL3 induced ferroptosis . Phase 3.
In vitro

FG-4592 is an oral inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase currently in clinical development for the treatment of anemia. FG-4592 stabilizes the activities of HIF, a cytosolic transcription factor, leading to activation of the genes associated with erythropoiesis, including erythropoietin and enzymes involved in iron metabolism.

In vivo

Cell Data

cell lines：MCF-7 cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyme

ASP1517 | 2-(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxamido)acetic acid

Spezifikationen & Reinheit

Moligand™, 10mM in DMSO

Biochemische und physiologische Mechanismen

Roxadustat (FG-4592) is an HIF-α prolyl hydroxylase inhibitor in a cell-free assay, stabilizes HIF-2 and induces EPO production. Roxadustat potentiates RSL3 induced ferroptosis. Phase 3.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

INHIBITOR

Mechanismus der Wirkung

Hypoxia-inducible factor prolyl hydroxylase inhibitor

Produkteigenschaften

ALogP

3.4

Namen und Kennungen

Isomere SMILES

CC1=C2C=C(C=CC2=C(C(=N1)C(=O)NCC(=O)O)O)OC3=CC=CC=C3

Molekulargewicht

352.34

Reaxy-Rn

11683248

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11683248&ln=

Zugehörige Ziele (menschlich)

EGLN1 Tclin Egl nine homolog 1 (6 Activities)

Discover Target: EGLN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Häufig gestellte Fragen

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 808118-40-3, the molecular formula is C19H16N2O5, and the molecular weight is 352.34 g/mol.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.