(RS)-APICA , CAS No.170847-18-4

CAS: 170847-18-4 Cat. No.: R288714 Summenformel: C₁₀H₁₂NO₅P Molekulargewicht: 257.18 PubChem CID: 4694355

Synonyms

(S)-MPPG (cyclic) | AKOS024456371 | (RS)-1-Amino-5-phosphonoindan-1-carboxylic acid | 1-Amino-5-phosphono-indan-1-carboxylic acid | DTXSID201028297 | 1-Amino-5-phosphono-indan-1-carboxylic acid(RS-APICA) | HY-101375 | SR-01000597477 | 1-amino-5-phosphono-

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Specifications

Synonyme

(S)-MPPG (cyclic) | AKOS024456371 | (RS)-1-Amino-5-phosphonoindan-1-carboxylic acid | 1-Amino-5-phosphono-indan-1-carboxylic acid | DTXSID201028297 | 1-Amino-5-phosphono-indan-1-carboxylic acid(RS-APICA) | HY-101375 | SR-01000597477 | 1-amino-5-phosphono-

Biochemische und physiologische Mechanismen

Rigidified analog of MPPG; selective group II metabotropic glutamate receptor antagonist (IC50= 30μM) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Increases extracellular glutamate concentrations and possesses

Storage

Store at 2-8°C,Desiccated

Verschickt in

Wet ice

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

ANTAGONIST

Namen und Kennungen

Kanonisches Lächeln

C1CC(C2=C1C=C(C=C2)P(=O)(O)O)(C(=O)O)N

IUPAC Name

1-amino-5-phosphono-2,3-dihydroindene-1-carboxylic acid

InChIKey

ZNQZXIHSJUDIKL-UHFFFAOYSA-N

INCHI

1S/C10H12NO5P/c11-10(9(12)13)4-3-6-5-7(17(14,15)16)1-2-8(6)10/h1-2,5H,3-4,11H2,(H,12,13)(H2,14,15,16)

Isomere SMILES

C1CC(C2=C1C=C(C=C2)P(=O)(O)O)(C(=O)O)N

PubChem CID

4694355

Molekulargewicht

257.18

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Klasse Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Ebene5 Amino acids and derivatives
          • Ebene6 Alpha amino acids and derivatives
            • Ebene7 Alpha amino acids

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Klasse: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Alpha amino acids
• Alternative Parents: Indanes Aralkylamines Organic phosphonic acids Amino acids Monocarboxylic acids and derivatives Carboxylic acids Organophosphorus compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Alpha-amino acid - Indane - Aralkylamine - Benzenoid - Organophosphonic acid - Organophosphonic acid derivative - Amino acid - Carboxylic acid - Monocarboxylic acid or derivatives - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Hydrocarbon derivative - Amine - Primary aliphatic amine - Organic oxygen compound - Organic oxide - Carbonyl group - Organophosphorus compound - Primary amine - Aromatic homopolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon).
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

GRM6 Tchem Metabotropic glutamate receptor 6 (361 Activities)

Discover Target: GRM6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GRM1 Tchem Metabotropic glutamate receptor 1 (2309 Activities)

Discover Target: GRM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GRM5 Tchem Metabotropic glutamate receptor 5 (5733 Activities)

Discover Target: GRM5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)

Discover Target: RGS4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Zugehörige Ziele (nicht menschlich)

Grm2 Metabotropic glutamate receptor 2 (1326 Activities)

Discover Target: Grm2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

Discover Target: ffp

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Solvent:1.1eq. NaOH, Max Conc. mg/mL: None, Max Conc. mM: 100
• Molekulargewicht: 257.180 g/mol
• XLogP3: -3.500
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 257.045 Da
• Monoisotopic Mass: 257.045 Da
• Topological Polar Surface Area: 121.000 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 381.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Häufig gestellte Fragen

How should this product be stored?

Store at 2–8 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 170847-18-4, the molecular formula is C10H12NO5P, and the molecular weight is 257.18 g/mol. InChIKey ZNQZXIHSJUDIKL-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.