S-Me-DM1 , CAS No.912569-84-7

CAS: 912569-84-7 Cat. No.: S276125 Summenformel: C₃₆H₅₀ClN₃O₁₀S Molekulargewicht: 752.31 PubChem CID: 154705356

Synonyms

N2'-Deacetyl-N2'-(3-thiomethyl-1-oxopropyl)-maytansine

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Übersicht

Shipped at 4°C. Store at -20°C. Store under desiccating conditions.

Specifications

Synonyme

N2'-Deacetyl-N2'-(3-thiomethyl-1-oxopropyl)-maytansine

Biochemische und physiologische Mechanismen

Active metabolite of Maytansine that inhibits in vitro polymerization of tubulin. Accumulates in cells and induces mitotic arrest.

Storage

Store at -20°C,Desiccated

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Hinweis

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Namen und Kennungen

Kanonisches Lächeln

CC1C2CC(C(C=CC=C(CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)CC(C4(C1O4)C)OC(=O)C(C)N(C)C(=O)CCSC)C)C)OC)(NC(=O)O2)O

IUPAC Name

[(1S,2R,3S,5S,6S,16Z,18Z,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[methyl(3-methylsulfanylpropanoyl)amino]propanoate

InChIKey

PLYHSTGTQYPYMT-UDXCHANISA-N

INCHI

1S/C36H50ClN3O10S/c1-20-11-10-12-27(47-8)36(45)19-26(48-34(44)38-36)21(2)32-35(4,50-32)28(49-33(43)22(3)39(5)29(41)13-14-51-9)18-30(42)40(6)24-16-23(15-20)17-25(46-7)31(24)37/h10-12,16-17,21-22,26-28,32,45H,13-15,18-19H2,1-9H3,(H,38,44)/b12-10-,20-11-/t21-,22+,26+,27-,28+,32+,35+,36+/m1/s1

PubChem CID

154705356

Molekulargewicht

752.31

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubilizes at ~3mg/mL in DMSO, ~3mg/mL in Chloroform, and ~3mg/mL in MeOH