(S)-V-0219 hydrochloride - ≥99% , CAS No.S659084

CAS: S659084 Cat. No.: S659084 Summenformel: C₂₀H₂₆ClF₃N₄O₂ Molekulargewicht: 446.89

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Übersicht

(S)-V-0219 hydrochloride is an enantiomer of V-0219 ( HY-143312 ). V-0219 is an orally active and positive allosteric modulator (PAM) of the GLP Receptor -1 ( GLP-1R ). (S)-V-0219 hydrochloride activates calcium fluxes in HEK cells stably expressing hGLP-

Appearance:Solid

IC50& Target:GLP-1R

In Vitro:(S)-V-0219 ((S)-9) (0.1 nM) hydrochloride potentiates calcium fluxes in HEK cells stably expressing hGLP-1R. (S)-V-0219 (0.1 nM) hydrochloride potentiates insulin secretion stimulated by GLP-1 in the stable human pancreatic cell line EndoC-βH1 under

In Vivo:(S)-V-0219 ((S)-9) (0.04-0.2mg/kg; i.p.) hydrochloride improves glucose handling after injection of 2 g/kg glucose in normal male Wistar rats. (S)-V-0219 (0. 4mg/kg; i.g.) hydrochloride is orally active in fatty diabetic Zucker rats. (S)-V-021

Biological Activity:(S)-V-0219 hydrochloride is an enantiomer of V-0219 ( HY-143312 ). V-0219 is an orally active and positive allosteric modulator (PAM) of the GLP Receptor -1 ( GLP-1R ). (S)-V-0219 hydrochloride activates calcium fluxes in HEK cells stably expressing hGLP-

Specifications

Spezifikationen & Reinheit

≥99%

Storage

Store at 2-8°C,Desiccated

Verschickt in

Wet ice

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

MODULATOR

Reinheit

≥99%

Namen und Kennungen

• Molekulargewicht: 446.89

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO : 100 mg/mL (223.77 mM; ultrasonic and warming and heat to 60°C)