sAJM589 - Moligand™,≥95% , CAS No.2089-82-9

CAS: 2089-82-9 Cat. No.: S649393 Summenformel: C₁₆H₁₀N₂O Molekulargewicht: 246.26 PubChem CID: 135480579

GRADE & PURITY Moligand™, ≥95%

Synonyms

5-Hydroxybenzo[a]phenazine | Benzo[a]phenazin-5-ol | benzo[a]phenazin-5(7H)-one

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

sAJM589 is a Myc inhibitor which potently disrupts the Myc-Max heterodimer with an IC 50 of 1.8 μM

In Vitro

sAJM589 potently disrupts the Myc-Max heterodimer to reduce Myc protein levels in a dose dependent manner, with an IC 50 of 1.8 μM. ?\nsAJM589 suppresses cellular proliferation in diverse Myc-dependent cancer cell lines and anchorage independent growth of Raji cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 1.8 μM (Myc)

Specifications

Synonyme

5-Hydroxybenzo[a]phenazine | Benzo[a]phenazin-5-ol | benzo[a]phenazin-5(7H)-one

Spezifikationen & Reinheit

Moligand™,≥95%

Biochemische und physiologische Mechanismen

sAJM589 is a Myc inhibitor which potently disrupts the Myc-Max heterodimer with an IC 50 of 1.8 μM.

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

INHIBITOR

Reinheit

≥95%

Namen und Kennungen

• Kanonisches Lächeln: C1=CC=C2C(=C1)C(=CC3=NC4=CC=CC=C4N=C23)O
• IUPAC Name: benzo[a]phenazin-5-ol
• InChIKey: WZBDRAAGHRCRKM-UHFFFAOYSA-N
• INCHI: 1S/C16H10N2O/c19-15-9-14-16(11-6-2-1-5-10(11)15)18-13-8-4-3-7-12(13)17-14/h1-9,19H
• Isomere SMILES: C1=CC=C2C(=C1)C(=CC3=NC4=CC=CC=C4N=C23)O
• PubChem CID: 135480579
• Molekulargewicht: 246.26

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Klasse Diazanaphthalenes
      • Subclass Benzodiazines
        • Ebene5 Quinoxalines
          • Ebene6 Phenazines and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Klasse: Diazanaphthalenes
• Subclass: Benzodiazines
• Intermediate Tree Nodes: Quinoxalines
• Direct Parent: Phenazines and derivatives
• Alternative Parents: Naphthols and derivatives 1-hydroxy-2-unsubstituted benzenoids Pyrazines Secondary ketimines Heteroaromatic compounds Propargyl-type 1,3-dipolar organic compounds Azacyclic compounds Organopnictogen compounds Organooxygen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phenazine - 1-naphthol - Naphthalene - 1-hydroxy-2-unsubstituted benzenoid - Benzenoid - Pyrazine - Heteroaromatic compound - Secondary ketimine - Ketimine - Azacycle - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Imine - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as phenazines and derivatives. These are polycyclic aromatic compounds containing a phenazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a pyrazine ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO : 5 mg/mL (20.30 mM; Need ultrasonic)
• Molekulargewicht: 246.260 g/mol
• XLogP3: 3.500
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 246.079 Da
• Monoisotopic Mass: 246.079 Da
• Topological Polar Surface Area: 46.000 Ų
• Heavy Atom Count: 19
• Formal Charge: 0
• Complexity: 335.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥95% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2089-82-9, the molecular formula is C16H10N2O, and the molecular weight is 246.26 g/mol. InChIKey WZBDRAAGHRCRKM-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.