SB-3CT - Moligand™, 10mM in DMSO , Inhibitor of MMP2;Inhibitor of MMP9, CAS No.292605-14-2, Inhibitor of MMP2;Inhibitor of MMP9

CAS: 292605-14-2 Cat. No.: S408624 Summenformel: C₁₅H₁₄O₃S₂ Molekulargewicht: 306.4 EG-Nummer: 684-085-5 PubChem CID: 9883002

QUALITÄT & REINHEIT Moligand™, 10mM in DMSO

Synonyms

2-[[(4-phenoxyphenyl)sulfonyl]methyl]-thiirane

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

SB-3CT SB-3CT is an effective and selective gelatinase inhibitor with K i of 13.9 nM and 600 nM for MMP-2 and MMP-9 , respectively.
In vitro

SB-3CT directly inhibits bone marrow endothelial cell invasion and tubule formation in Matrigel in vitro.

In vivo

In L-CI.5s T-cell lymphoma model, SB-3CT (5-50 mg/kg/d i.p.) potently inhibit liver metastasis and increases survival of mice. SB-3CT (50 mg/kg/d i.p.) inhibits human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model. In a mouse model of embolus-induced “permanent” focal cerebral ischemia, SB-3CT counteracts degradation of neuronal laminin, protects neurons from ischemic cell death, and ameliorates neurobehavioral outcomes after embolic MCA occlusion.
Cell Data

cell lines：A10 cells (Vascular SMC)

Concentrations：

Incubation Time：

Powder Purity:≥97%

Spezifikationen

Synonyme

2-[[(4-phenoxyphenyl)sulfonyl]methyl]-thiirane

Spezifikationen & Reinheit

Moligand™, 10mM in DMSO

Biochemische und physiologische Mechanismen

SB-3CT is an effective and selective gelatinase inhibitor with K_i of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

INHIBITOR

Mechanismus der Wirkung

Inhibitor of MMP2;Inhibitor of MMP9

Namen und Kennungen

Isomere SMILES

C1C(S1)CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=CC=C3

PubChem CID

9883002

Molekulargewicht

306.4

Zugehörige Ziele (menschlich)

MMP14 Tchem Matrix metalloproteinase-14 (2 Activities)

Discover Target: MMP14

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP9 Tchem Matrix metalloproteinase-9 (6 Activities)

Discover Target: MMP9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP2 Tchem 72 kDa type IV collagenase (6 Activities)

Discover Target: MMP2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro DMSO: 100 mg/mL (97.06 mM); Ethanol: 100 mg/mL (97.06 mM); Water: Insoluble
• Schmelzpunkt (°C): 101 °C