SBI-425 - 10mM in DMSO , CAS No.1451272-71-1

CAS: 1451272-71-1 Cat. No.: S656179 Summenformel: C₁₃H₁₂ClN₃O₄S Molekulargewicht: 341.77 PubChem CID: 89768286

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

SBI-425 is an orally active and potent TNAP ( tissue-nonspecific alkaline phosphatase ) inhibitor ( IC 50 =16 nM). SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival

In Vitro

SBI-425 treatment suppresses Foxp3 expression in CD4 + and CD8 + T cells in splenocytes from CLP-injured mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

1.19 Mouse PK parameters for SBI-425 Compds SBI-425 Cl p (mL/min/kg) 5.14 Vd (L/kg) 1.03 C max (μg/mL) 178 AUC (μg*hr/mL) 848 t 1/2 (hr) 2.3 %F 58 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 16 nM (TNAP)

Specifications

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

SBI-425 is an orally active and potent TNAP ( tissue-nonspecific alkaline phosphatase ) inhibitor ( IC 50 =16 nM). SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Namen und Kennungen

• Isomere SMILES: COC1=C(C=C(C=C1)Cl)S(=O)(=O)NC2=CN=CC(=C2)C(=O)N
• PubChem CID: 89768286
• MeSH-Eintrag: 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide;SBI-425
• Molekulargewicht: 341.77

Zugehörige Ziele (menschlich)

ALPL Tchem Alkaline phosphatase, tissue-nonspecific isozyme (2 Activities)

Discover Target: ALPL

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Häufig gestellte Fragen

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1451272-71-1, the molecular formula is C13H12ClN3O4S, and the molecular weight is 341.77 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.