Schz 1 - ≥98%(HPLC) , CAS No.326886-05-9

CAS: 326886-05-9 Cat. No.: S287579 Summenformel: C₁₃H₁₁BrN₂O₃S Molekulargewicht: 355.21 EG-Nummer: 806-202-2 PubChem CID: 135446537

QUALITÄT & REINHEIT ≥98%(HPLC)

Synonyms

EN300-1212502 | MS-25546 | Z49626720 | E98660 | N'-(5-BROMO-2-HYDROXYBENZYLIDENE)BENZENESULFONOHYDRAZIDE | N-[(E)-(5-bromo-2-hydroxyphenyl)methylideneamino]benzenesulfonamide | HY-108440 | N'-[(E)-(5-bromo-2-hydroxyphenyl)methylidene]benzenesulfonohydrazi

Storage

Lagerung bei -20°C

Shipped In

Eistruhe + Eispads

Übersicht

Beschreibung des Produkts

Shz-1, ein kleines kardiogenes Molekül, induziert verschiedene herzspezifische Gene, darunter sarkomeres Tropomyosin in P19CL6-Zellen. Shz-1 induziert die Expression von Nkx2.5 in der Maus. Shz-1 aktiviert die durch den Axolotl-TPM4-Promotor gesteuerte ektopische Expression in C2C12-Zellen.

Spezifikationen

Synonyme

EN300-1212502 | MS-25546 | Z49626720 | E98660 | N'-(5-BROMO-2-HYDROXYBENZYLIDENE)BENZENESULFONOHYDRAZIDE | N-[(E)-(5-bromo-2-hydroxyphenyl)methylideneamino]benzenesulfonamide | HY-108440 | N'-[(E)-(5-bromo-2-hydroxyphenyl)methylidene]benzenesulfonohydrazi

Spezifikationen & Reinheit

≥98%(HPLC)

Biochemische und physiologische Mechanismen

Aktivator früher Herzgene (einschließlichNkx2.5) in pluripotenten Stammzellen. Induziert phänotypische Differenzierung in menschlichen mobilisierten mononukleären Zellen des peripheren Blutes. Verbessert die Regeneration des Herzmuskels durch Stammzellen

Storage

Lagerung bei -20°C

Verschickt in

Eistruhe + Eispads

Reinheit

≥98%(HPLC)

Namen und Kennungen

Pubchem Sid

488202918

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488202918

Kanonisches Lächeln

C1=CC=C(C=C1)S(=O)(=O)NN=CC2=C(C=CC(=C2)Br)O

IUPAC Name

N-[(E)-(5-bromo-2-hydroxyphenyl)methylideneamino]benzenesulfonamide

InChIKey

OEMCLQLAWYKPRK-OQLLNIDSSA-N

INCHI

1S/C13H11BrN2O3S/c14-11-6-7-13(17)10(8-11)9-15-16-20(18,19)12-4-2-1-3-5-12/h1-9,16-17H/b15-9+

Isomere SMILES

C1=CC=C(C=C1)S(=O)(=O)N/N=C/C2=C(C=CC(=C2)Br)O

PubChem CID

135446537

Molekulargewicht

355.21

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Klasse Benzene and substituted derivatives
      • Subclass Benzenesulfonamides

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Klasse: Benzene and substituted derivatives
• Subclass: Benzenesulfonamides
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzenesulfonamides
• Alternative Parents: Benzenesulfonyl compounds P-bromophenols Bromobenzenes 1-hydroxy-2-unsubstituted benzenoids Sulfonohydrazides Hydrazinosulfonyl compounds Aryl bromides Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organobromides Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Benzenesulfonamide - Benzenesulfonyl group - 4-halophenol - 4-bromophenol - Bromobenzene - Halobenzene - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Sulfonohydrazide - Hydrazinosulfonyl compound - Aryl bromide - Aryl halide - Sulfonyl - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Organic oxide - Organooxygen compound - Organonitrogen compound - Organobromide - Organohalogen compound - Organosulfur compound - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Organopnictogen compound - Aromatic homomonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (nicht menschlich)

Candida albicans (78123 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Solvent:DMSO, Max Conc. mg/mL: 35.52, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 17.76, Max Conc. mM: 50
• Molekulargewicht: 355.210 g/mol
• XLogP3: 2.900
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 353.967 Da
• Monoisotopic Mass: 353.967 Da
• Topological Polar Surface Area: 87.100 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 429.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1

Häufig gestellte Fragen

What is the purity of this product, and how is it determined?

This product is supplied at ≥98% purity, determined by HPLC. Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 326886-05-9, the molecular formula is C13H11BrN2O3S, and the molecular weight is 355.21 g/mol. InChIKey OEMCLQLAWYKPRK-OQLLNIDSSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.