SKA 121 - Moligand™, ≥98%(HPLC) , Activator of K Ca3.1, CAS No.1820708-73-3, Activator of K Ca3.1

CAS: 1820708-73-3 Cat. No.: S287446 Summenformel: C₁₂H₁₀N₂O Molekulargewicht: 198.23 PubChem CID: 91827362

GRADE & PURITY Moligand™, ≥98%(HPLC)

Synonyms

5-Methylnaphth[2,1-d]oxazol-2-amine | SKA-121 | 5-Methylnaphth[2,1-d]oxazol-2-amine, 5-Methylnaphtho[2,1-d]oxazol-2-amine | SKA121 | 5-methyl-naphth[2,1-d]oxazol-2-amine

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

Product description：

SKA-121 is a selective KCa3.1 activator. SKA-121 exhibits EC50s of 109 nM and 4.4 μM for KCa3.1 and KCa2.3, respectively.

Specifications

Synonyme

5-Methylnaphth[2,1-d]oxazol-2-amine | SKA-121 | 5-Methylnaphth[2,1-d]oxazol-2-amine, 5-Methylnaphtho[2,1-d]oxazol-2-amine | SKA121 | 5-methyl-naphth[2,1-d]oxazol-2-amine

Spezifikationen & Reinheit

Moligand™, ≥98%(HPLC)

Biochemische und physiologische Mechanismen

Positive allosteric modulator of KCa3.1 (intermediate-conductance Ca2+-activated potassium) channels (EC50= 109 nM). Displays 40-fold selectivity for KCa3.1 over KCa2.3, and 200 to 400-fold selectivity over KVand NaVchannels. Potentiates bradykinin-induce

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

ACTIVATOR

Mechanismus der Wirkung

Activator of K Ca3.1

Reinheit

≥98%(HPLC)

Namen und Kennungen

• Kanonisches Lächeln: CC1=CC2=C(C3=CC=CC=C13)OC(=N2)N
• IUPAC Name: 5-methylbenzo[g][1,3]benzoxazol-2-amine
• InChIKey: JEGUERWMMMQFJV-UHFFFAOYSA-N
• INCHI: 1S/C12H10N2O/c1-7-6-10-11(15-12(13)14-10)9-5-3-2-4-8(7)9/h2-6H,1H3,(H2,13,14)
• Isomere SMILES: CC1=CC2=C(C3=CC=CC=C13)OC(=N2)N
• PubChem CID: 91827362
• MeSH-Eintrag: 5-methylnaphtho(2,1-d)oxazol-2-amine;SKA-121
• Molekulargewicht: 198.23

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Klasse Naphthalenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Klasse: Naphthalenes
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Naphthalenes
• Alternative Parents: Benzoxazoles Oxazoles Heteroaromatic compounds Oxacyclic compounds Azacyclic compounds Primary amines Organooxygen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Naphthalene - Benzoxazole - Azole - Oxazole - Heteroaromatic compound - Azacycle - Organoheterocyclic compound - Oxacycle - Primary amine - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Amine - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as naphthalenes. These are compounds containing a naphthalene moiety, which consists of two fused benzene rings.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

KCNN4 Tchem Intermediate conductance calcium-activated potassium channel protein 4 (1 Activities)

Discover Target: KCNN4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemische und physikalische Eigenschaften

• Löslichkeit: Solvent:DMSO, Max Conc. mg/mL: 19.82, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 9.91, Max Conc. mM: 50
• Molekulargewicht: 198.220 g/mol
• XLogP3: 3.000
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 198.079 Da
• Monoisotopic Mass: 198.079 Da
• Topological Polar Surface Area: 52.100 Ų
• Heavy Atom Count: 15
• Formal Charge: 0
• Complexity: 246.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1