Solifenacin succinate - 10mM in Water , Muscarinic acetylcholine receptor M2 antagonist, CAS No.242478-38-2, Muscarinic acetylcholine receptor M2 antagonist

CAS: 242478-38-2 Cat. No.: S408550 Summenformel: C₂₃H₂₆N₂O·C₄H₆O₄ Molekulargewicht: 480.55 EG-Nummer: 620-505-5 PubChem CID: 216457

GRADE & PURITY 10mM in Water

Synonyms

YM905 | Butanedioic acid, compd. with (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

Solifenacin succinate (YM905) is a urinary antispasmodic of the antimuscarinic class.
In vitro

Solifenacin succinate is a new muscarinic receptor antagonist developed for the treatment of overactive bladder. The affinity constants (pKi) of solifenacin for recombinant human muscarinic M1, M2 and M3 receptors are 7.6, 6.9 and 8.0, respectively. Hence, the muscarinic M3 receptor subtype selectivity of solifenacin over the muscarinic M2 receptor subtype is readily apparent, but is only marginal over the muscarinic M1 receptor subtype. In the same study, solifenacin and oxybutynin inhibit muscarinic M3 receptor-mediated intracellular Ca2+ mobilization in bladder smooth muscle cells isolated from guinea pigs and in submandibular gland cells isolated from mice.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyme

YM905 | Butanedioic acid, compd. with (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate (1:1)

Spezifikationen & Reinheit

10mM in Water

Biochemische und physiologische Mechanismen

Solifenacin succinate (YM905) is a urinary antispasmodic of the antimuscarinic class.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

ANTAGONIST

Mechanismus der Wirkung

Muscarinic acetylcholine receptor M2 antagonist

Namen und Kennungen

• Isomere SMILES: C1CN2CCC1[C@H](C2)OC(=O)N3CCC4=CC=CC=C4[C@@H]3C5=CC=CC=C5.C(CC(=O)O)C(=O)O
• PubChem CID: 216457
• Molekulargewicht: 480.55

Zugehörige Ziele (menschlich)

CHRM1 Tclin Muscarinic acetylcholine receptor M1 (1 Activities)

Discover Target: CHRM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro DMSO: 59 mg/mL (197.5 mM); Water: 59 mg/mL (197.5 mM); Ethanol: Insoluble
• Schmelzpunkt (°C): 147 °C